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Protein
Submitted name:

Dynamin 1-like, isoform CRA_f

Gene

DNM1L

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Dynamin 1-like, isoform CRA_fImported
Gene namesi
Name:DNM1LImported
ORF Names:hCG_1810949Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiD3DUW6.

Expressioni

Gene expression databases

BgeeiENSG00000087470.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000450399.

Structurei

3D structure databases

ProteinModelPortaliD3DUW6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 355Dynamin-type G (guanine nucleotide-binding)InterPro annotationAdd BLAST281
Domaini671 – 762GEDInterPro annotationAdd BLAST92

Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0446. Eukaryota.
COG0699. LUCA.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030556. DNM1L.
IPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PTHR11566:SF39. PTHR11566:SF39. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3DUW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACREGAGSR RARSNGCRLP RRGRRRGGRR RTVGPGPIHC RGRRALGPRV
60 70 80 90 100
FRVMEALIPV INKLQDVFNT VGADIIQLPQ IVVVGTQSSG KSSVLESLVG
110 120 130 140 150
RDLLPRGTGI VTRRPLILQL VHVSQEDKRK TTGEENGVEA EEWGKFLHTK
160 170 180 190 200
NKLYTDFDEI RQEIENETER ISGNNKGVSP EPIHLKIFSP NVVNLTLVDL
210 220 230 240 250
PGMTKVPVGD QPKDIELQIR ELILRFISNP NSIILAVTAA NTDMATSEAL
260 270 280 290 300
KISREVDPDG RRTLAVITKL DLMDAGTDAM DVLMGRVIPV KLGIIGVVNR
310 320 330 340 350
SQLDINNKKS VTDSIRDEYA FLQKKYPSLA NRNGTKYLAR TLNRLLMHHI
360 370 380 390 400
RDCLPELKTR INVLAAQYQS LLNSYGEPVD DKSATLLQLI TKFATEYCNT
410 420 430 440 450
IEGTAKYIET SELCGGARIC YIFHETFGRT LESVDPLGGL NTIDILTAIR
460 470 480 490 500
NATGPRPALF VPEVSFELLV KRQIKRLEEP SLRCVELVHE EMQRIIQHCS
510 520 530 540 550
NYSTQELLRF PKLHDAIVEV VTCLLRKRLP VTNEMVHNLV AIELAYINTK
560 570 580 590 600
HPDFADACGL MNNNIEEQRR NRLARELPSA VSRDKLIQDS RRETKNVASG
610 620 630 640 650
GGGVGDGVQE PTTGNWRGML KTSKAEELLA EEKSKPIPIM PASPQKGHAV
660 670 680 690 700
NLLDVPVPVA RKLSAREQRD CEVIERLIKS YFLIVRKNIQ DSVPKAVMHF
710 720 730 740 750
LVNHVKDTLQ SELVGQLYKS SLLDDLLTES EDMAQRRKEA ADMLKALQGA
760
SQIIAEIRET HLW
Length:763
Mass (Da):85,376
Last modified:March 23, 2010 - v1
Checksum:i75FBF86F27A471C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471116 Genomic DNA. Translation: EAW88526.1.
CH471116 Genomic DNA. Translation: EAW88527.1.
UniGeneiHs.556296.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471116 Genomic DNA. Translation: EAW88526.1.
CH471116 Genomic DNA. Translation: EAW88527.1.
UniGeneiHs.556296.

3D structure databases

ProteinModelPortaliD3DUW6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000450399.

Proteomic databases

PRIDEiD3DUW6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0446. Eukaryota.
COG0699. LUCA.

Miscellaneous databases

ChiTaRSiDNM1L. human.

Gene expression databases

BgeeiENSG00000087470.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030556. DNM1L.
IPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PTHR11566:SF39. PTHR11566:SF39. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD3DUW6_HUMAN
AccessioniPrimary (citable) accession number: D3DUW6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: November 30, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.