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D3DT93

- D3DT93_HUMAN

UniProt

D3DT93 - D3DT93_HUMAN

Protein
Submitted name:

TNF receptor-associated factor 5, isoform CRA_a

Gene

TRAF5

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (23 Mar 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. signal transducer activity Source: Ensembl
    2. ubiquitin-protein transferase activity Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. positive regulation of cell proliferation Source: Ensembl
    2. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: InterPro
    3. regulation of apoptotic process Source: InterPro

    Keywords - Molecular functioni

    ReceptorImported

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    TNF receptor-associated factor 5, isoform CRA_aImported
    Gene namesi
    Name:TRAF5Imported
    ORF Names:hCG_24260Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA

    Structurei

    3D structure databases

    SMRiD3DT93. Positions 94-284, 429-620.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 MATH domain.UniRule annotation
    Contains RING-type zinc finger.SAAS annotation

    Keywords - Domaini

    Zinc-fingerUniRule annotationSAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000231557.
    KOiK09849.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    3.90.890.10. 1 hit.
    InterProiIPR002083. MATH.
    IPR013323. SIAH-type.
    IPR012227. TNF_rcpt--assoc_TRAF.
    IPR008974. TRAF-like.
    IPR027130. TRAF5.
    IPR018957. Znf_C3HC4_RING-type.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    IPR001293. Znf_TRAF.
    [Graphical view]
    PANTHERiPTHR10131:SF66. PTHR10131:SF66. 1 hit.
    PfamiPF00917. MATH. 1 hit.
    PF00097. zf-C3HC4. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015614. TRAF. 1 hit.
    SMARTiSM00061. MATH. 1 hit.
    SM00184. RING. 1 hit.
    [Graphical view]
    SUPFAMiSSF49599. SSF49599. 3 hits.
    PROSITEiPS50144. MATH. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    PS50145. ZF_TRAF. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3DT93-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTVSASSRPL PARPLFPCAR PRPSARAPAP PQASPPLRRR RRPQPGAAAA    50
    PADRPRGARA PSPTMAYSEE HKGMPCGFIR QNSGNSISLD FEPSIEYQFV 100
    ERLEERYKCA FCHSVLHNPH QTGCGHRFCQ HCILSLRELN TVPICPVDKE 150
    VIKSQEVFKD NCCKREVLNL YVYCSNAPGC NAKVILGRYQ DHLQQCLFQP 200
    VQCSNEKCRE PVLRKDLKEH LSASCQFRKE KCLYCKKDVV VINLQNHEEN 250
    LCPEYPVFCP NNCAKIILKT EVDEHLAVCP EAEQDCPFKH YGCAVTDKRR 300
    NLQQHEHSAL REHMRLVLEK NVQLEEQISD LHKSLEQKES KIQQLAETIK 350
    KLEKEFKQFA QLFGKNGSFL PNIQVFASHI DKSAWLEAQV HQLLQMVNQQ 400
    QNKFDLRPLM EAVDTVKQKI TLLENNDQRL AVLEEETNKH DTHINIHKAQ 450
    LSKNEERFKL LEGTCYNGKL IWKVTDYKMK KREAVDGHTV SIFSQSFYTS 500
    RCGYRLCARA YLNGDGSGRG SHLSLYFVVM RGEFDSLLQW PFRQRVTLML 550
    LDQSGKKNIM ETFKPDPNSS SFKRPDGEMN IASGCPRFVA HSVLENAKNA 600
    YIKDDTLFLK VAVDLTDLED L 621
    Length:621
    Mass (Da):71,113
    Last modified:March 23, 2010 - v1
    Checksum:iA771F6D04B5F9515
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH471100 Genomic DNA. Translation: EAW93419.1.
    CH471100 Genomic DNA. Translation: EAW93421.1.
    RefSeqiXP_005273306.1. XM_005273249.2.
    UniGeneiHs.523930.

    Genome annotation databases

    GeneIDi7188.
    KEGGihsa:7188.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH471100 Genomic DNA. Translation: EAW93419.1 .
    CH471100 Genomic DNA. Translation: EAW93421.1 .
    RefSeqi XP_005273306.1. XM_005273249.2.
    UniGenei Hs.523930.

    3D structure databases

    SMRi D3DT93. Positions 94-284, 429-620.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 7188.
    KEGGi hsa:7188.

    Organism-specific databases

    CTDi 7188.

    Phylogenomic databases

    HOGENOMi HOG000231557.
    KOi K09849.

    Miscellaneous databases

    ChiTaRSi TRAF5. human.
    GenomeRNAii 7188.
    NextBioi 35490038.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    3.90.890.10. 1 hit.
    InterProi IPR002083. MATH.
    IPR013323. SIAH-type.
    IPR012227. TNF_rcpt--assoc_TRAF.
    IPR008974. TRAF-like.
    IPR027130. TRAF5.
    IPR018957. Znf_C3HC4_RING-type.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    IPR001293. Znf_TRAF.
    [Graphical view ]
    PANTHERi PTHR10131:SF66. PTHR10131:SF66. 1 hit.
    Pfami PF00917. MATH. 1 hit.
    PF00097. zf-C3HC4. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015614. TRAF. 1 hit.
    SMARTi SM00061. MATH. 1 hit.
    SM00184. RING. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49599. SSF49599. 3 hits.
    PROSITEi PS50144. MATH. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    PS50145. ZF_TRAF. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of the human genome."
      Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
      , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
      Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiD3DT93_HUMAN
    AccessioniPrimary (citable) accession number: D3DT93
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 23, 2010
    Last sequence update: March 23, 2010
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.