D3DT93 (D3DT93_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
TNF receptor-associated factor 5, isoform CRA_a EMBL EAW93421.1

Gene names

Name:	TRAF5 EMBL EAW93421.1
ORF Names:	hCG_24260 EMBL EAW93421.1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	621 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 MATH domain. RuleBase RU004402 Contains 1 RING-type zinc finger. SAAS SAAS008974

Ontologies

Keywords
Domain	Zinc-finger RuleBase RU000353 SAAS SAAS008974
Ligand	Metal-binding Zinc
Molecular function	Receptor EMBL EAW93421.1
Gene Ontology (GO)
Biological_process	positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from electronic annotation. Source: InterPro positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara regulation of apoptotic process Inferred from electronic annotation. Source: InterPro
Molecular_function	signal transducer activity Inferred from electronic annotation. Source: Compara ubiquitin-protein ligase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	D3DT93 [UniParc]. Last modified March 23, 2010. Version 1. Checksum: A771F6D04B5F9515	FASTA	621	71,113
	10 20 30 40 50 60 MTVSASSRPL PARPLFPCAR PRPSARAPAP PQASPPLRRR RRPQPGAAAA PADRPRGARA 70 80 90 100 110 120 PSPTMAYSEE HKGMPCGFIR QNSGNSISLD FEPSIEYQFV ERLEERYKCA FCHSVLHNPH 130 140 150 160 170 180 QTGCGHRFCQ HCILSLRELN TVPICPVDKE VIKSQEVFKD NCCKREVLNL YVYCSNAPGC 190 200 210 220 230 240 NAKVILGRYQ DHLQQCLFQP VQCSNEKCRE PVLRKDLKEH LSASCQFRKE KCLYCKKDVV 250 260 270 280 290 300 VINLQNHEEN LCPEYPVFCP NNCAKIILKT EVDEHLAVCP EAEQDCPFKH YGCAVTDKRR 310 320 330 340 350 360 NLQQHEHSAL REHMRLVLEK NVQLEEQISD LHKSLEQKES KIQQLAETIK KLEKEFKQFA 370 380 390 400 410 420 QLFGKNGSFL PNIQVFASHI DKSAWLEAQV HQLLQMVNQQ QNKFDLRPLM EAVDTVKQKI 430 440 450 460 470 480 TLLENNDQRL AVLEEETNKH DTHINIHKAQ LSKNEERFKL LEGTCYNGKL IWKVTDYKMK 490 500 510 520 530 540 KREAVDGHTV SIFSQSFYTS RCGYRLCARA YLNGDGSGRG SHLSLYFVVM RGEFDSLLQW 550 560 570 580 590 600 PFRQRVTLML LDQSGKKNIM ETFKPDPNSS SFKRPDGEMN IASGCPRFVA HSVLENAKNA 610 620 YIKDDTLFLK VAVDLTDLED L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The sequence of the human genome." Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H. , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X. Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH471100 Genomic DNA. Translation: EAW93419.1. CH471100 Genomic DNA. Translation: EAW93421.1.
IPI	IPI00005760.
UniGene	Hs.523930.
3D structure databases
ProteinModelPortal	D3DT93.
SMR	D3DT93. Positions 94-284, 429-620.
ModBase	Search...
Proteomic databases
PRIDE	D3DT93.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOGENOM	HOG000231557.
Enzyme and pathway databases
SignaLink	D3DT93.
Gene expression databases
ArrayExpress	D3DT93.
Bgee	D3DT93.
Family and domain databases
Gene3D	3.30.40.10. 1 hit. 3.90.890.10. 1 hit.
InterPro	IPR002083. MATH. IPR013323. SIAH-type. IPR012227. TNF_rcpt--assoc_TRAF. IPR008974. TRAF-like. IPR027130. TRAF5. IPR018957. Znf_C3HC4_RING-type. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. IPR017907. Znf_RING_CS. IPR001293. Znf_TRAF. [Graphical view]
PANTHER	PTHR10131:SF23. PTHR10131:SF23. 1 hit.
Pfam	PF00917. MATH. 1 hit. PF00097. zf-C3HC4. 1 hit. [Graphical view]
PIRSF	PIRSF015614. TRAF. 1 hit.
SMART	SM00061. MATH. 1 hit. SM00184. RING. 1 hit. [Graphical view]
SUPFAM	SSF49599. Traf_like. 3 hits.
PROSITE	PS50144. MATH. 1 hit. PS00518. ZF_RING_1. 1 hit. PS50089. ZF_RING_2. 1 hit. PS50145. ZF_TRAF. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TRAF5. human.
NextBio	35490038.

Entry information

Entry name

D3DT93_HUMAN

Accession

Primary (citable) accession number: D3DT93

Entry history

Integrated into UniProtKB/TrEMBL:	March 23, 2010
Last sequence update:	March 23, 2010
Last modified:	May 29, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.