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Protein
Submitted name:

Collagen, type XVIII, alpha 1, isoform CRA_b

Gene

COL18A1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Collagen, type XVIII, alpha 1, isoform CRA_bImported
Gene namesi
Name:COL18A1Imported
ORF Names:hCG_1647196Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrixSAAS annotation, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 15161493Sequence analysisPRO_5007650937Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PeptideAtlasiD3DSM5.

Expressioni

Gene expression databases

BgeeiENSG00000182871.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000347665.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini221 – 409189LAM_G_DOMAINInterPro annotationAdd
BLAST

Keywords - Domaini

CollagenSAAS annotationImported, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3546. Eukaryota.
ENOG410XQ04. LUCA.
HOGENOMiHOG000231591.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR008160. Collagen.
IPR010515. Collagenase_NC10/endostatin.
IPR013320. ConA-like_dom.
IPR010363. DUF959_COL18_N.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF01391. Collagen. 5 hits.
PF06121. DUF959. 1 hit.
PF06482. Endostatin. 1 hit.
[Graphical view]
SMARTiSM00210. TSPN. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF56436. SSF56436. 1 hit.

Sequencei

Sequence statusi: Complete.

D3DSM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPYPCGCHI LLLLFCCLAA ARANLLNLNW LWFNNEDTSH AATTIPEPQG
60 70 80 90 100
PLPVQPTADT TTHVTPRNGS TEPATAPGSP EPPSELLEDG QDTPTSAESP
110 120 130 140 150
DAPEENIAGV GAEILNVAKG IRSFVQLWND TVPTESLARA ETLVLETPVG
160 170 180 190 200
PLALAGPSST PQENGTTLWP SRGIPSSPGA HTTEAGTLPA PTPSPPSLGR
210 220 230 240 250
PWAPLTGPSV PPPSSERISE EVGLLQLLGD PPPQQVTQTD DPDVGLAYVF
260 270 280 290 300
GPDANSGQVA RYHFPSLFFR DFSLLFHIRP ATEGPGVLFA ITDSAQAMVL
310 320 330 340 350
LGVKLSGVQD GHQDISLLYT EPGAGQTHTA ASFRLPAFVG QWTHLALSVA
360 370 380 390 400
GGFVALYVDC EEFQRMPLAR SSRGLELEPG AGLFVAQAGG ADPDKFQGVI
410 420 430 440 450
AELKVRRDPQ VSPMHCLDEE GDDSDGASGD SGSGLGDARE LLREETGAAL
460 470 480 490 500
KPRLPAPPPV TTPPLAGGSS TEDSRSEEVE EQTTVASLGA QTLPGSDSVS
510 520 530 540 550
TWDGSVRTPG GRVKEGGLKG QKGEPGVPGP PGRAGPPGSP CLPGPPGLPC
560 570 580 590 600
PVSPLGPAGP ALQTVPGPQG PPGPPGRDGT PGRDGEPGDP GEDGKPGDTG
610 620 630 640 650
PQGFPGTPGD VGPKGDKGDP GVGERGPPGP QGPPGPPGPS FRHDKLTFID
660 670 680 690 700
MEGSGFGGDL EALRGPRGFP GPPGPPGVPG LPGEPGRFGV NSSDVPGPAG
710 720 730 740 750
LPGVPGREGP PGFPGLPGPP GPPGREGPPG RTGQKGSLGE AGAPGHKGSK
760 770 780 790 800
GAPGPAGARG ESGLAGAPGP AGPPGPPGPP GPPGPGLPAG FDDMEGSGGP
810 820 830 840 850
FWSTARSADG PQGPPGLPGL KGDPGVPGLP GAKGEVGADG VPGFPGLPGR
860 870 880 890 900
EGIAGPQGPK GDRGSRGEKG DPGKDGVGQP GLPGPPGPPG PVVYVSEQDG
910 920 930 940 950
SVLSVPGPEG RPGFAGFPGP AGPKGNLGSK GERGSPGPKG EKGEPGSIFS
960 970 980 990 1000
PDGGALGPAQ KGAKGEPGFR GPPGPYGRPG YKGEIGFPGR PGRPGMNGLK
1010 1020 1030 1040 1050
GEKGEPGDAS LGFGMRGMPG PPGPPGPPGP PGTPVYDSNV FAESSRPGPP
1060 1070 1080 1090 1100
GLPGNQGPPG PKGAKGEVGP PGPPGQFPFD FLQLEAEMKG EKGDRGDAGQ
1110 1120 1130 1140 1150
KGERGEPGGG GFFGSSLPGP PGPPGPRGYP GIPGPKGESI RGQPGPPGPQ
1160 1170 1180 1190 1200
GPPGIGYEGR QGPPGPPGPP GPPSFPGPHR QTISVPGPPG PPGPPGPPGT
1210 1220 1230 1240 1250
MGASSGVRLW ATRQAMLGQV HEVPEGWLIF VAEQEELYVR VQNGFRKVQL
1260 1270 1280 1290 1300
EARTPLPRGT DNEVAALQPP VVQLHDSNPY PRREHPHPTA RPWRADDILA
1310 1320 1330 1340 1350
SPPRLPEPQP YPGAPHHSSY VHLRPARPTS PPAHSHRDFQ PVLHLVALNS
1360 1370 1380 1390 1400
PLSGGMRGIR GADFQCFQQA RAVGLAGTFR AFLSSRLQDL YSIVRRADRA
1410 1420 1430 1440 1450
AVPIVNLKDE LLFPSWEALF SGSEGPLKPG ARIFSFDGKD VLRHPTWPQK
1460 1470 1480 1490 1500
SVWHGSDPNG RRLTESYCET WRTEAPSATG QASSLLGGRL LGQSAASCHH
1510
AYIVLCIENS FMTASK
Length:1,516
Mass (Da):153,767
Last modified:March 23, 2010 - v1
Checksum:i3CE0B6A21DAC50D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471079 Genomic DNA. Translation: EAX09339.1.
CH471079 Genomic DNA. Translation: EAX09344.1.
RefSeqiNP_085059.2. NM_030582.3.
UniGeneiHs.517356.

Genome annotation databases

GeneIDi80781.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471079 Genomic DNA. Translation: EAX09339.1.
CH471079 Genomic DNA. Translation: EAX09344.1.
RefSeqiNP_085059.2. NM_030582.3.
UniGeneiHs.517356.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000347665.

Proteomic databases

PeptideAtlasiD3DSM5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi80781.

Organism-specific databases

CTDi80781.

Phylogenomic databases

eggNOGiKOG3546. Eukaryota.
ENOG410XQ04. LUCA.
HOGENOMiHOG000231591.

Miscellaneous databases

ChiTaRSiCOL18A1. human.
GenomeRNAii80781.

Gene expression databases

BgeeiENSG00000182871.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR008160. Collagen.
IPR010515. Collagenase_NC10/endostatin.
IPR013320. ConA-like_dom.
IPR010363. DUF959_COL18_N.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF01391. Collagen. 5 hits.
PF06121. DUF959. 1 hit.
PF06482. Endostatin. 1 hit.
[Graphical view]
SMARTiSM00210. TSPN. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF56436. SSF56436. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiD3DSM5_HUMAN
AccessioniPrimary (citable) accession number: D3DSM5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: September 7, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.