SH3GL2

Functionⁱ

GO - Biological processⁱ

endocytosis Source: InterPro

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: SH3-domain GRB2-like 2, isoform CRA_bImported
Gene namesⁱ	Name:SH3GL2Imported ORF Names:hCG_28367Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	D3DRJ2.

PeptideAtlasⁱ

D3DRJ2.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 214	BARInterPro annotationAdd BLAST		214
Domainⁱ	255 – 314	SH3InterPro annotationAdd BLAST		60

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	195 – 215	Sequence analysisAdd BLAST		21

Keywords - Domainⁱ

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG1118. Eukaryota. ENOG410XNYB. LUCA.

eggNOGⁱ

KOG1118. Eukaryota.
ENOG410XNYB. LUCA.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd11803. SH3_Endophilin_A. 1 hit.
Gene3Dⁱ	1.20.1270.60. 1 hit.
InterProⁱ	View protein in InterPro IPR027267. AH/BAR_dom_sf. IPR004148. BAR_dom. IPR028501. Endophilin-A. IPR035824. Endophilin_A_SH3. IPR036028. SH3-like_dom_sf. IPR001452. SH3_domain.
PANTHERⁱ	PTHR43965. PTHR43965. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03114. BAR. 1 hit. PF07653. SH3_2. 1 hit.
PRINTSⁱ	PR00452. SH3DOMAIN.
SMARTⁱ	View protein in SMART SM00721. BAR. 1 hit. SM00326. SH3. 1 hit.
SUPFAMⁱ	SSF103657. SSF103657. 1 hit. SSF50044. SSF50044. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51021. BAR. 1 hit. PS50002. SH3. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

D3DRJ2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MERKVDVTSR AVMEIMTKTI EYLQPNPASR AKLSMINTMS KIRGQEKGPG 
        60         70         80         90        100
YPQAEALLAE AMLKFGRELG DDCNFGPALG EVGEAMRELS EVKDSLDIEV 
       110        120        130        140        150
KQNFIDPLQN LHDKDLREIQ HHLKKLEGRR LDFDYKKKRQ GKIPDEELRQ 
       160        170        180        190        200
ALEKFDESKE IAESSMFNLL EMDIEQVSQL SALVQAQLEY HKQAVQILQQ 
       210        220        230        240        250
VTVRLEERIR QASSQPRREY QPKPRMSLEF PTGDSTQPNG GLSHTGTPKP 
       260        270        280        290        300
SGVQMDQPCC RALYDFEPEN EGELGFKEGD IITLTNQIDE NWYEGMLHGH 
       310 
SGFFPINYVE ILVALPH

Length:317

Mass (Da):36,172

Last modified:March 23, 2010 - v1

Checksum:ⁱC8917B8E7D6C4E01

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH471071 Genomic DNA. Translation: EAW58662.1. CH471071 Genomic DNA. Translation: EAW58663.1.
UniGeneⁱ	Hs.743740. Hs.75149.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
D3DRJ2	Q99962 F7IB79 A0A2I3SZG1 A0A2I2Y4S8 A0A2J8XI81 A0A2I3HW13 Q3V639 Q7Z376 UPI0004F05348 A0A2K5EFV0 +3	Homo sapiens (Human) Callithrix jacchus (White-tufted-ear marmoset) Pan troglodytes (Chimpanzee) Gorilla gorilla gorilla (Western lowland gorilla) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Aotus nancymaae (Ma's night monkey) Saimiri boliviensis boliviensis (Bolivian squirrel monkey)	352	UniRef100_Q99962	Cluster: Endophilin-A1	14

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
D3DRJ2	Q99962 F7IB79 A0A2I3SZG1 A0A2I2Y4S8 A0A2J8XI81 A0A2I3HW13 Q3V639 Q7Z376 UPI0004F05348 A0A2K5EFV0 +56	Homo sapiens (Human) Callithrix jacchus (White-tufted-ear marmoset) Pan troglodytes (Chimpanzee) Gorilla gorilla gorilla (Western lowland gorilla) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Aotus nancymaae (Ma's night monkey) Saimiri boliviensis boliviensis (Bolivian squirrel monkey) Ovis aries (Sheep) Bos mutus (wild yak) And more	352	UniRef90_Q99962	Cluster: Endophilin-A1	67

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
D3DRJ2	Q99962 F7IB79 A0A2I3SZG1 A0A2I2Y4S8 A0A2J8XI81 A0A2I3HW13 Q3V639 Q7Z376 UPI0004F05348 A0A2K5EFV0 +83	Homo sapiens (Human) Callithrix jacchus (White-tufted-ear marmoset) Pan troglodytes (Chimpanzee) Gorilla gorilla gorilla (Western lowland gorilla) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Aotus nancymaae (Ma's night monkey) Saimiri boliviensis boliviensis (Bolivian squirrel monkey) Ovis aries (Sheep) Bos mutus (wild yak) And more	352	UniRef50_Q99962	Cluster: Endophilin-A1	94

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH471071 Genomic DNA. Translation: EAW58662.1. CH471071 Genomic DNA. Translation: EAW58663.1.
UniGeneⁱ	Hs.743740. Hs.75149.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	D3DRJ2.

PeptideAtlasⁱ

D3DRJ2.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Phylogenomic databases

eggNOGⁱ	KOG1118. Eukaryota. ENOG410XNYB. LUCA.

eggNOGⁱ

KOG1118. Eukaryota.
ENOG410XNYB. LUCA.

Miscellaneous databases

ChiTaRSⁱ	SH3GL2. human.

ChiTaRSⁱ

SH3GL2. human.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd11803. SH3_Endophilin_A. 1 hit.
Gene3Dⁱ	1.20.1270.60. 1 hit.
InterProⁱ	View protein in InterPro IPR027267. AH/BAR_dom_sf. IPR004148. BAR_dom. IPR028501. Endophilin-A. IPR035824. Endophilin_A_SH3. IPR036028. SH3-like_dom_sf. IPR001452. SH3_domain.
PANTHERⁱ	PTHR43965. PTHR43965. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03114. BAR. 1 hit. PF07653. SH3_2. 1 hit.
PRINTSⁱ	PR00452. SH3DOMAIN.
SMARTⁱ	View protein in SMART SM00721. BAR. 1 hit. SM00326. SH3. 1 hit.
SUPFAMⁱ	SSF103657. SSF103657. 1 hit. SSF50044. SSF50044. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51021. BAR. 1 hit. PS50002. SH3. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	D3DRJ2_HUMAN
Accessionⁱ	D3DRJ2Primary (citable) accession number: D3DRJ2
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 23, 2010
	Last sequence update:	March 23, 2010
	Last modified:	February 28, 2018
	This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

UniProtKB - D3DRJ2 (D3DRJ2_HUMAN)

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SH3-domain GRB2-like 2, isoform CRA_b

Select a section on the left to see content.

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Other locations

PTM / Processingⁱ

Proteomic databases

Family & Domainsⁱ

Domains and Repeats

Coiled coil

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - D3DRJ2 (D3DRJ2_HUMAN)

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SH3-domain GRB2-like 2, isoform CRA_b

SH3GL2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Phylogenomic databases

Family and domain databases

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ