SH3GL2

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: SH3-domain GRB2-like 2, isoform CRA_bImported
Gene namesⁱ	Name:SH3GL2Imported ORF Names:hCG_28367Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Subcellular locationⁱ

GO - Cellular componentⁱ

cytoplasm Source: InterPro

Complete GO annotation...

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000107295.

Bgeeⁱ

ENSG00000107295.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000369981.

STRINGⁱ

9606.ENSP00000369981.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 214	BARInterPro annotationAdd BLAST		214
Domainⁱ	255 – 314	SH3InterPro annotationAdd BLAST		60

Keywords - Domainⁱ

SH3 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG1118. Eukaryota. ENOG410XNYB. LUCA.

eggNOGⁱ

KOG1118. Eukaryota.
ENOG410XNYB. LUCA.

Family and domain databases

InterProⁱ	View protein in InterPro IPR027267. AH/BAR-dom. IPR004148. BAR_dom. IPR011511. SH3_2. IPR001452. SH3_domain. IPR013315. Spectrin_alpha_SH3.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03114. BAR. 1 hit. PF07653. SH3_2. 1 hit.
PRINTSⁱ	PR00452. SH3DOMAIN. PR01887. SPECTRNALPHA.
SMARTⁱ	View protein in SMART SM00721. BAR. 1 hit. SM00326. SH3. 1 hit.
SUPFAMⁱ	SSF103657. SSF103657. 1 hit. SSF50044. SSF50044. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51021. BAR. 1 hit. PS50002. SH3. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

D3DRJ2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MERKVDVTSR AVMEIMTKTI EYLQPNPASR AKLSMINTMS KIRGQEKGPG 
        60         70         80         90        100
YPQAEALLAE AMLKFGRELG DDCNFGPALG EVGEAMRELS EVKDSLDIEV 
       110        120        130        140        150
KQNFIDPLQN LHDKDLREIQ HHLKKLEGRR LDFDYKKKRQ GKIPDEELRQ 
       160        170        180        190        200
ALEKFDESKE IAESSMFNLL EMDIEQVSQL SALVQAQLEY HKQAVQILQQ 
       210        220        230        240        250
VTVRLEERIR QASSQPRREY QPKPRMSLEF PTGDSTQPNG GLSHTGTPKP 
       260        270        280        290        300
SGVQMDQPCC RALYDFEPEN EGELGFKEGD IITLTNQIDE NWYEGMLHGH 
       310 
SGFFPINYVE ILVALPH

Length:317

Mass (Da):36,172

Last modified:March 23, 2010 - v1

Checksum:ⁱC8917B8E7D6C4E01

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH471071 Genomic DNA. Translation: EAW58662.1. CH471071 Genomic DNA. Translation: EAW58663.1.
UniGeneⁱ	Hs.743740. Hs.75149.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH471071 Genomic DNA. Translation: EAW58662.1. CH471071 Genomic DNA. Translation: EAW58663.1.
UniGeneⁱ	Hs.743740. Hs.75149.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000369981.

STRINGⁱ

9606.ENSP00000369981.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Phylogenomic databases

eggNOGⁱ	KOG1118. Eukaryota. ENOG410XNYB. LUCA.

eggNOGⁱ

KOG1118. Eukaryota.
ENOG410XNYB. LUCA.

Miscellaneous databases

ChiTaRSⁱ	SH3GL2. human.

ChiTaRSⁱ

SH3GL2. human.

Gene expression databases

Bgeeⁱ	ENSG00000107295.

Bgeeⁱ

ENSG00000107295.

Family and domain databases

InterProⁱ	View protein in InterPro IPR027267. AH/BAR-dom. IPR004148. BAR_dom. IPR011511. SH3_2. IPR001452. SH3_domain. IPR013315. Spectrin_alpha_SH3.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03114. BAR. 1 hit. PF07653. SH3_2. 1 hit.
PRINTSⁱ	PR00452. SH3DOMAIN. PR01887. SPECTRNALPHA.
SMARTⁱ	View protein in SMART SM00721. BAR. 1 hit. SM00326. SH3. 1 hit.
SUPFAMⁱ	SSF103657. SSF103657. 1 hit. SSF50044. SSF50044. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51021. BAR. 1 hit. PS50002. SH3. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	D3DRJ2_HUMAN
Accessionⁱ	D3DRJ2Primary (citable) accession number: D3DRJ2
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 23, 2010
	Last sequence update:	March 23, 2010
	Last modified:	June 7, 2017
	This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB - D3DRJ2 (D3DRJ2_HUMAN)

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SH3-domain GRB2-like 2, isoform CRA_b

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Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Expressionⁱ

Gene expression databases

Interactionⁱ

Protein-protein interaction databases

Family & Domainsⁱ

Domains and Repeats

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

Similar proteinsⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - D3DRJ2 (D3DRJ2_HUMAN)

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SH3-domain GRB2-like 2, isoform CRA_b

SH3GL2

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ