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D3DPA4

- D3DPA4_HUMAN

UniProt

D3DPA4 - D3DPA4_HUMAN

Protein
Submitted name:

Activin A receptor, type I

Gene

ACVR1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (23 Mar 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotation

    GO - Molecular functioni

    1. activin receptor activity, type I Source: Ensembl
    2. ATP binding Source: UniProtKB-KW
    3. receptor signaling protein serine/threonine kinase activity Source: Ensembl
    4. transforming growth factor beta receptor activity, type I Source: Ensembl

    GO - Biological processi

    1. acute inflammatory response Source: Ensembl
    2. cellular response to glucocorticoid stimulus Source: Ensembl
    3. determination of left/right symmetry Source: Ensembl
    4. gastrulation with mouth forming second Source: Ensembl
    5. germ cell development Source: Ensembl
    6. heart development Source: Ensembl
    7. in utero embryonic development Source: Ensembl
    8. mesoderm formation Source: Ensembl
    9. neural crest cell migration Source: Ensembl
    10. patterning of blood vessels Source: Ensembl
    11. pharyngeal system development Source: Ensembl
    12. regulation of skeletal muscle tissue development Source: Ensembl
    13. smooth muscle cell differentiation Source: Ensembl
    14. transforming growth factor beta receptor signaling pathway Source: Ensembl
    15. urogenital system development Source: Ensembl

    Keywords - Molecular functioni

    Kinase, ReceptorSAAS annotationImported, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Activin A receptor, type IImported
    Submitted name:
    Activin A receptor, type I, isoform CRA_bImported
    Gene namesi
    Name:ACVR1Imported
    ORF Names:hCG_1811747Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. activin receptor complex Source: Ensembl
    2. apical part of cell Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Structurei

    3D structure databases

    SMRiD3DPA4. Positions 143-499.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protein kinase superfamily.UniRule annotation
    Contains protein kinase domain.SAAS annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    KOiK04675.
    OMAiVCEGMSC.
    PhylomeDBiD3DPA4.

    Family and domain databases

    InterProiIPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view]
    PANTHERiPTHR23255. PTHR23255. 1 hit.
    PfamiPF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view]
    PRINTSiPR00653. ACTIVIN2R.
    SMARTiSM00467. GS. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3DPA4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVDGVMILPV LIMIALPSPS MEDEKPKVNP KLYMCVCEGL SCGNEDHCEG    50
    QQCFSSLSIN DGFHVYQKGC FQVYEQGKMT CKTPPSPGQA VECCQGDWCN 100
    RNITAQLPTK GKSFPGTQNF HLEVGLIILS VVFAVCLLAC LLGVALRKFK 150
    RRNQERLNPR DVEYGTIEGL ITTNVGDSTL ADLLDHSCTS GSGSGLPFLV 200
    QRTVARQITL LECVGKGRYG EVWRGSWQGE NVAVKIFSSR DEKSWFRETE 250
    LYNTVMLRHE NILGFIASDM TSRHSSTQLW LITHYHEMGS LYDYLQLTTL 300
    DTVSCLRIVL SIASGLAHLH IEIFGTQGKP AIAHRDLKSK NILVKKNGQC 350
    CIADLGLAVM HSQSTNQLDV GNNPRVGTKR YMAPEVLDET IQVDCFDSYK 400
    RVDIWAFGLV LWEVARRMVS NGIVEDYKPP FYDVVPNDPS FEDMRKVVCV 450
    DQQRPNIPNR WFSDPTLTSL AKLMKECWYQ NPSARLTALR IKKTLTKIDN 500
    SLDKLKTDC 509
    Length:509
    Mass (Da):57,153
    Last modified:March 23, 2010 - v1
    Checksum:iE2B0F051D19DD052
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HM015588 Genomic DNA. Translation: ADL14509.1.
    CH471058 Genomic DNA. Translation: EAX11439.1.
    CH471058 Genomic DNA. Translation: EAX11440.1.
    CH471058 Genomic DNA. Translation: EAX11443.1.
    RefSeqiNP_001096.1. NM_001105.4.
    NP_001104537.1. NM_001111067.2.
    XP_005246996.1. XM_005246939.1.
    XP_005246997.1. XM_005246940.1.
    XP_006712888.1. XM_006712825.1.
    UniGeneiHs.470316.

    Genome annotation databases

    GeneIDi90.
    KEGGihsa:90.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HM015588 Genomic DNA. Translation: ADL14509.1 .
    CH471058 Genomic DNA. Translation: EAX11439.1 .
    CH471058 Genomic DNA. Translation: EAX11440.1 .
    CH471058 Genomic DNA. Translation: EAX11443.1 .
    RefSeqi NP_001096.1. NM_001105.4.
    NP_001104537.1. NM_001111067.2.
    XP_005246996.1. XM_005246939.1.
    XP_005246997.1. XM_005246940.1.
    XP_006712888.1. XM_006712825.1.
    UniGenei Hs.470316.

    3D structure databases

    SMRi D3DPA4. Positions 143-499.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 90.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 90.
    KEGGi hsa:90.

    Organism-specific databases

    CTDi 90.

    Phylogenomic databases

    KOi K04675.
    OMAi VCEGMSC.
    PhylomeDBi D3DPA4.

    Miscellaneous databases

    GenomeRNAii 90.
    NextBioi 335.

    Family and domain databases

    InterProi IPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view ]
    PANTHERi PTHR23255. PTHR23255. 1 hit.
    Pfami PF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view ]
    PRINTSi PR00653. ACTIVIN2R.
    SMARTi SM00467. GS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of the human genome."
      Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
      , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
      Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE.
    3. Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiD3DPA4_HUMAN
    AccessioniPrimary (citable) accession number: D3DPA4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 23, 2010
    Last sequence update: March 23, 2010
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.