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Protein

Carboxylic ester hydrolase

Gene

BCHE

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation

Protein family/group databases

ESTHERihuman-BCHE BCHE

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxylic ester hydrolaseUniRule annotation (EC:3.1.1.-UniRule annotation)
Gene namesi
Name:BCHEImported
ORF Names:hCG_14822Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei46 – 65HelicalSequence analysisAdd BLAST20
Transmembranei85 – 103HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiD3DNN4
PRIDEiD3DNN4

Structurei

3D structure databases

SMRiD3DNN4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 591COesteraseInterPro annotationAdd BLAST520
Domaini606 – 641AChE_tetraInterPro annotationAdd BLAST36

Sequence similaritiesi

Belongs to the type-B carboxylesterase/lipase family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG4389 Eukaryota
COG2272 LUCA
HOGENOMiHOG000091866

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR014788 AChE_tetra
IPR002018 CarbesteraseB
IPR019826 Carboxylesterase_B_AS
IPR019819 Carboxylesterase_B_CS
IPR000997 Cholinesterase
PfamiView protein in Pfam
PF08674 AChE_tetra, 1 hit
PF00135 COesterase, 1 hit
PRINTSiPR00878 CHOLNESTRASE
ProDomiView protein in ProDom or Entries sharing at least one domain
PD415333 AChE_tetra, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00122 CARBOXYLESTERASE_B_1, 1 hit
PS00941 CARBOXYLESTERASE_B_2, 1 hit

Sequencei

Sequence statusi: Complete.

D3DNN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVQSNLQAG AAAASCISPK YYMIFTPCKL CHLCCRESEI NMHSKVTIIC
60 70 80 90 100
IRFLFWFLLL CMLIGKSHTE DDIIIATKNG KVRGMNLTVF GGTVTAFLGI
110 120 130 140 150
PYAQPPLGRL RFKKPQSLTK WSDIWNATKY ANSCCQNIDQ SFPGFHGSEM
160 170 180 190 200
WNPNTDLSED CLYLNVWIPA PKPKNATVLI WIYGGGFQTG TSSLHVYDGK
210 220 230 240 250
FLARVERVIV VSMNYRVGAL GFLALPGNPE APGNMGLFDQ QLALQWVQKN
260 270 280 290 300
IAAFGGNPKS VTLFGESAGA ASVSLHLLSP GSHSLFTRAI LQSGSFNAPW
310 320 330 340 350
AVTSLYEARN RTLNLAKLTG CSRENETEII KCLRNKDPQE ILLNEAFVVP
360 370 380 390 400
YGTPLSVNFG PTVDGDFLTD MPDILLELGQ FKKTQILVGV NKDEGTAFLV
410 420 430 440 450
YGAPGFSKDN NSIITRKEFQ EGLKIFFPGV SEFGKESILF HYTDWVDDQR
460 470 480 490 500
PENYREALGD VVGDYNFICP ALEFTKKFSE WGNNAFFYYF EHRSSKLPWP
510 520 530 540 550
EWMGVMHGYE IEFVFGLPLE RRDNYTKAEE ILSRSIVKRW ANFAKYGNPN
560 570 580 590 600
ETQNNSTSWP VFKSTEQKYL TLNTESTRIM TKLRAQQCRF WTSFFPKVLE
610 620 630 640
MTGNIDEAEW EWKAGFHRWN NYMMDWKNQF NDYTSKKESC VGL
Length:643
Mass (Da):72,883
Last modified:March 23, 2010 - v1
Checksum:i8B6A327007F31B1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471052 Genomic DNA Translation: EAW78592.1
CH471052 Genomic DNA Translation: EAW78593.1
RefSeqiXP_016862456.1, XM_017006967.1
UniGeneiHs.420483

Similar proteinsi

Entry informationi

Entry nameiD3DNN4_HUMAN
AccessioniPrimary (citable) accession number: D3DNN4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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