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D3DK92 (D3DK92_HYDTT) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddlA EMBL BAI70244.1
Synonyms:ddl HAMAP-Rule MF_00047
Ordered Locus Names:HTH_1800 EMBL BAI70244.1, Hydth_1782 EMBL ADO46163.1
OrganismHydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6) [Complete proteome] [HAMAP]
Taxonomic identifier608538 [NCBI]
Taxonomic lineageBacteriaAquificaeAquificalesAquificaceaeHydrogenobacter

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. SAAS SAAS011095 HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. SAAS SAAS011095 HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. SAAS SAAS011095 HAMAP-Rule MF_00047

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. SAAS SAAS011095 HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity SAAS SAAS011095 HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain99 – 288190ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding125 – 17652ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2421Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2551Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2551Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2571Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
D3DK92 [UniParc].

Last modified March 23, 2010. Version 1.
Checksum: 438D54741C8BC778

FASTA28832,326
        10         20         30         40         50         60 
MRVVVLMGGR SEEREISLKT GEAVLRAIRE LGHEAIPLDL EENLCQKLLE IKPDKVFIAL 

        70         80         90        100        110        120 
HGTYGEDGRV QGLLDILGIP YTGSGVLGSC LAMDKDITKK ILTFHRIPVP AGICVRRGET 

       130        140        150        160        170        180 
FEWHSFPAVV KPADQGSSVG LFLVKDHDEL ENAVREVLSI SHKVLIEEYI IGRDITVGIL 

       190        200        210        220        230        240 
KGEALPPVEI KPKKGIYDYE SKYTKGMSDY VFLEDEKLIK KLQDIALMVH KYLELKDISR 

       250        260        270        280 
VDFRLSEDGV AYVLEANTIP GMTELSLFPM MCKKKGIEFK EMIHMLLS 

« Hide

References

[1]"Complete genome sequence of the thermophilic, obligately chemolithoautotrophic hydrogen-oxidizing bacterium Hydrogenobacter thermophilus TK-6."
Arai H., Kanbe H., Ishii M., Igarashi Y.
J. Bacteriol. 192:2651-2652(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 6534 / IAM 12695 / TK-6 [Tokyo] and TK-6.
[2]"Complete genome sequence of Hydrogenobacter thermophilus type strain (TK-6)."
US DOE Joint Genome Institute (JGI-PGF)
Zeytun A., Sikorski J., Nolan M., Lapidus A., Lucas S., Han J., Tice H., Cheng J., Tapia R., Goodwin L., Pitluck S., Liolios K., Ivanova N., Mavromatis K., Mikhailova N., Ovchinnikova G., Pati A., Chen A. expand/collapse author list , Palaniappan K., Ngatchou O., Land M., Hauser L., Chang Y., Jeffries C., Han C., Detter J., Ubler S., Rohde M., Tindall B., Wirth R., Woyke T., Bristow J., Eisen J., Markowitz V., Hugenholtz P., Klenk H., Kyrpides N.
Stand. Genomic Sci. 4:131-143(2011)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 6534 / IAM 12695 / TK-6 [JGI] and TK-6 EMBL ADO46163.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002221 Genomic DNA. Translation: ADO46163.1.
AP011112 Genomic DNA. Translation: BAI70244.1.
RefSeqYP_003433445.1. NC_013799.1.
YP_005512456.1. NC_017161.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADO46163; ADO46163; Hydth_1782.
BAI70244; BAI70244; HTH_1800.
GeneID12101702.
8773599.
KEGGhte:Hydth_1782.
hth:HTH_1800.
PATRIC32212547. VBIHydThe36152_1805.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011592.
KOK01921.
OMARSAYGIY.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD3DK92_HYDTT
AccessionPrimary (citable) accession number: D3DK92
Entry history
Integrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: July 9, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)