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D3DK92

- D3DK92_HYDTT

UniProt

D3DK92 - D3DK92_HYDTT

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Protein

D-alanine--D-alanine ligase

Gene
ddlA, ddl, HTH_1800, Hydth_1782
Organism
Hydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotations

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi242 – 2421Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi255 – 2551Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi255 – 2551Magnesium or manganese 2 By similarityUniRule annotation
Metal bindingi257 – 2571Magnesium or manganese 2 By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi125 – 17652ATP By similarityUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  2. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotations, Peptidoglycan synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotationSAAS annotations, ManganeseUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene namesi
Name:ddlAImported
Synonyms:ddlUniRule annotation
Ordered Locus Names:HTH_1800Imported, Hydth_1782Imported
OrganismiHydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6)
Taxonomic identifieri608538 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeHydrogenobacter
ProteomesiUP000002574: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliD3DK92.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini99 – 288190ATP-grasp By similarityUniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ATP-grasp domain.UniRule annotation
Contains ATP-grasp domain.SAAS annotations

Phylogenomic databases

HOGENOMiHOG000011592.
KOiK01921.
OMAiRSAYGIY.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3DK92-1 [UniParc]FASTAAdd to Basket

« Hide

MRVVVLMGGR SEEREISLKT GEAVLRAIRE LGHEAIPLDL EENLCQKLLE    50
IKPDKVFIAL HGTYGEDGRV QGLLDILGIP YTGSGVLGSC LAMDKDITKK 100
ILTFHRIPVP AGICVRRGET FEWHSFPAVV KPADQGSSVG LFLVKDHDEL 150
ENAVREVLSI SHKVLIEEYI IGRDITVGIL KGEALPPVEI KPKKGIYDYE 200
SKYTKGMSDY VFLEDEKLIK KLQDIALMVH KYLELKDISR VDFRLSEDGV 250
AYVLEANTIP GMTELSLFPM MCKKKGIEFK EMIHMLLS 288
Length:288
Mass (Da):32,326
Last modified:March 23, 2010 - v1
Checksum:i438D54741C8BC778
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002221 Genomic DNA. Translation: ADO46163.1.
AP011112 Genomic DNA. Translation: BAI70244.1.
RefSeqiWP_012964424.1. NC_017161.1.
YP_003433445.1. NC_013799.1.
YP_005512456.1. NC_017161.1.

Genome annotation databases

EnsemblBacteriaiADO46163; ADO46163; Hydth_1782.
BAI70244; BAI70244; HTH_1800.
GeneIDi12101702.
8773599.
KEGGihte:Hydth_1782.
hth:HTH_1800.
PATRICi32212547. VBIHydThe36152_1805.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002221 Genomic DNA. Translation: ADO46163.1 .
AP011112 Genomic DNA. Translation: BAI70244.1 .
RefSeqi WP_012964424.1. NC_017161.1.
YP_003433445.1. NC_013799.1.
YP_005512456.1. NC_017161.1.

3D structure databases

ProteinModelPortali D3DK92.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADO46163 ; ADO46163 ; Hydth_1782 .
BAI70244 ; BAI70244 ; HTH_1800 .
GeneIDi 12101702.
8773599.
KEGGi hte:Hydth_1782.
hth:HTH_1800.
PATRICi 32212547. VBIHydThe36152_1805.

Phylogenomic databases

HOGENOMi HOG000011592.
KOi K01921.
OMAi RSAYGIY.

Enzyme and pathway databases

UniPathwayi UPA00219 .

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPi MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the thermophilic, obligately chemolithoautotrophic hydrogen-oxidizing bacterium Hydrogenobacter thermophilus TK-6."
    Arai H., Kanbe H., Ishii M., Igarashi Y.
    J. Bacteriol. 192:2651-2652(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 6534 / IAM 12695 / TK-6 [Tokyo] and TK-6.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 6534 / IAM 12695 / TK-6 [JGI] and TK-6Imported.

Entry informationi

Entry nameiD3DK92_HYDTT
AccessioniPrimary (citable) accession number: D3DK92
Entry historyi
Integrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: September 3, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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