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Protein

Superoxide dismutase [Cu-Zn]

Gene

sodC

Organism
Hydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Cu cationUniRule annotationNote: Binds 1 copper ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

CopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:sodCImported
Ordered Locus Names:HTH_0932Imported, Hydth_0928Imported
OrganismiHydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6)Imported
Taxonomic identifieri608538 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeHydrogenobacter
ProteomesiUP000002574: Chromosome, UP000008982: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini24 – 174151 PotentialImportedPRO_5000650764Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliD3DHT9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Keywords - Domaini

SignalImported

Phylogenomic databases

HOGENOMiHOG000263448.
KOiK04565.
OMAiAPRFESS.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3DHT9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGGLSCLSSG MALCAVLFSF SIAQELKAHA DIVNQKGEKI GKAELIQTNS
60 70 80 90 100
GVLIKLEASN LPPNAELAFH IHELGKCDPP DFMSAKGHFN PFKKKHGLLN
110 120 130 140 150
PDGPHAGDMP NVFTDANGNL KVHVLNTFVT LERGKENSLL KDGGTALMIH
160 170
HHRDDYRTDP AGDAGARIAC GVIK
Length:174
Mass (Da):18,617
Last modified:March 23, 2010 - v1
Checksum:i59F44A66E8E32125
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002221 Genomic DNA. Translation: ADO45324.1.
AP011112 Genomic DNA. Translation: BAI69391.1.
RefSeqiWP_012963571.1. NC_017161.1.
YP_003432592.1. NC_013799.1.
YP_005511617.1. NC_017161.1.

Genome annotation databases

EnsemblBacteriaiADO45324; ADO45324; Hydth_0928.
BAI69391; BAI69391; HTH_0932.
GeneIDi12101075.
8772556.
KEGGihte:Hydth_0928.
hth:HTH_0932.
PATRICi32210771. VBIHydThe36152_0940.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002221 Genomic DNA. Translation: ADO45324.1.
AP011112 Genomic DNA. Translation: BAI69391.1.
RefSeqiWP_012963571.1. NC_017161.1.
YP_003432592.1. NC_013799.1.
YP_005511617.1. NC_017161.1.

3D structure databases

ProteinModelPortaliD3DHT9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADO45324; ADO45324; Hydth_0928.
BAI69391; BAI69391; HTH_0932.
GeneIDi12101075.
8772556.
KEGGihte:Hydth_0928.
hth:HTH_0932.
PATRICi32210771. VBIHydThe36152_0940.

Phylogenomic databases

HOGENOMiHOG000263448.
KOiK04565.
OMAiAPRFESS.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the thermophilic, obligately chemolithoautotrophic hydrogen-oxidizing bacterium Hydrogenobacter thermophilus TK-6."
    Arai H., Kanbe H., Ishii M., Igarashi Y.
    J. Bacteriol. 192:2651-2652(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TK-6.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 6534 / IAM 12695 / TK-6 [JGI]Imported and TK-6Imported.

Entry informationi

Entry nameiD3DHT9_HYDTT
AccessioniPrimary (citable) accession number: D3DHT9
Entry historyi
Integrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: January 7, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.