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Protein
Submitted name:

Elongation factor EF-Tu

Gene

tufA1

Organism
Hydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 268GTPUniRule annotation
Nucleotide bindingi85 – 895GTPUniRule annotation
Nucleotide bindingi140 – 1434GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-HAMAP
  3. translation elongation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Elongation factorUniRule annotationImported

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Elongation factor EF-TuImported
Submitted name:
Translation elongation factor TuImported
Gene namesi
Name:tufA1Imported
Synonyms:tufUniRule annotation, tufA2Imported
Ordered Locus Names:HTH_0853Imported, HTH_0866Imported, Hydth_0853Imported, Hydth_0866Imported
OrganismiHydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6)Imported
Taxonomic identifieri608538 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeHydrogenobacter
ProteomesiUP000002574 Componenti: Chromosome UP000008982 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229290.
KOiK02358.
OMAiDEGGRHN.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3DHL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKEKFIREK EHVNVGTIGH VDHGKSTLTS AITCVLAAGV LPGGKAKCTK
60 70 80 90 100
YEEIDKAPEE KERGITINIT HVEYETPKRH YAHVDCPGHA DYIKNMITGA
110 120 130 140 150
AQMDGAILVV SAADGPMPQT REHVLLARQV NVPYIVVFMN KCDMVDDPEL
160 170 180 190 200
LDLVELEVRE LLSKYEFPGD EVPVIRGSAL GALQELEQGK PDRWCNAIVE
210 220 230 240 250
LLKAMDEYVP TPVREADKPF LMPIEDVFSI SGRGTVVTGR VERGVLKPGE
260 270 280 290 300
EVEIVGIREE PLKTVATSIE MFRKILDEAL PGDNVGVLLR GVGKDDVERG
310 320 330 340 350
QVLAKPGTVK PHKRFRAQVY VLSKEEGGRH TPFFVNYRPQ FYFRTADVTG
360 370 380 390 400
TVVKLPEGQE MVMPGDNVEL EVELIQPVAM EEGLRFAIRE GGRTVGAGVV

TQILD
Length:405
Mass (Da):44,728
Last modified:March 22, 2010 - v1
Checksum:i159ADE82C8DFF133
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002221 Genomic DNA. Translation: ADO45250.1.
CP002221 Genomic DNA. Translation: ADO45263.1.
AP011112 Genomic DNA. Translation: BAI69313.1.
AP011112 Genomic DNA. Translation: BAI69326.1.
RefSeqiYP_003432514.1. NC_013799.1.
YP_003432527.1. NC_013799.1.
YP_005511543.1. NC_017161.1.
YP_005511556.1. NC_017161.1.

Genome annotation databases

EnsemblBacteriaiADO45250; ADO45250; Hydth_0853.
ADO45263; ADO45263; Hydth_0866.
BAI69313; BAI69313; HTH_0853.
BAI69326; BAI69326; HTH_0866.
KEGGihte:Hydth_0853.
hte:Hydth_0866.
hth:HTH_0853.
hth:HTH_0866.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002221 Genomic DNA. Translation: ADO45250.1.
CP002221 Genomic DNA. Translation: ADO45263.1.
AP011112 Genomic DNA. Translation: BAI69313.1.
AP011112 Genomic DNA. Translation: BAI69326.1.
RefSeqiYP_003432514.1. NC_013799.1.
YP_003432527.1. NC_013799.1.
YP_005511543.1. NC_017161.1.
YP_005511556.1. NC_017161.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADO45250; ADO45250; Hydth_0853.
ADO45263; ADO45263; Hydth_0866.
BAI69313; BAI69313; HTH_0853.
BAI69326; BAI69326; HTH_0866.
KEGGihte:Hydth_0853.
hte:Hydth_0866.
hth:HTH_0853.
hth:HTH_0866.

Phylogenomic databases

HOGENOMiHOG000229290.
KOiK02358.
OMAiDEGGRHN.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the thermophilic, obligately chemolithoautotrophic hydrogen-oxidizing bacterium Hydrogenobacter thermophilus TK-6."
    Arai H., Kanbe H., Ishii M., Igarashi Y.
    J. Bacteriol. 192:2651-2652(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 6534 / IAM 12695 / TK-6 [Tokyo]Imported and TK-6.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 6534 / IAM 12695 / TK-6 [JGI]Imported and TK-6Imported.

Entry informationi

Entry nameiD3DHL1_HYDTT
AccessioniPrimary (citable) accession number: D3DHL1
Entry historyi
Integrated into UniProtKB/TrEMBL: March 22, 2010
Last sequence update: March 22, 2010
Last modified: March 31, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.