SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

D3DHB2

- D3DHB2_HYDTT

UniProt

D3DHB2 - D3DHB2_HYDTT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Alanine racemase
Gene
alr, HTH_0754, Hydth_0754
Organism
Hydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei33 – 331Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei126 – 1261Substrate By similarityUniRule annotation
Active sitei236 – 2361Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei284 – 2841Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:HTH_0754Imported, Hydth_0754Imported
OrganismiHydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6)
Taxonomic identifieri608538 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeHydrogenobacter
ProteomesiUP000002574: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD3DHB2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiAEININN.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3DHB2-1 [UniParc]FASTAAdd to Basket

« Hide

MARAVLEIDA DAIRQNIKAI RDFSGKRVIA VVKADAYGIG AVHICPILEA    50
LDEVSSFAVA CVEEGIELRK AGIKKDILIL GGVFKGERKA LIEYALTPVV 100
SHEAHLRAIE GLDIGFHVKY DTGMGRLGFF EDVLIKDRRV KGVLTHLSSP 150
LDKDFSLMQI EKFKKIVKAY SNVDIHLESS AGIVYMVPFA THVRIGLAMY 200
GEKPAPDYPI ELKRAISIKA RILSVKYLPP SYPVSYSRTF ITDRKKKVGV 250
VAFGYADGLA KALSNVGCLY WKDKPLRILG NITMDMTMVD LDDTDAQVGD 300
EVEVVGPHQS FSHLAKLAGT IPYEIMCHLS SRIKRVVV 338
Length:338
Mass (Da):37,315
Last modified:March 23, 2010 - v1
Checksum:iDD077B82BA883592
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002221 Genomic DNA. Translation: ADO45151.1.
AP011112 Genomic DNA. Translation: BAI69214.1.
RefSeqiWP_012963395.1. NC_017161.1.
YP_003432415.1. NC_013799.1.
YP_005511444.1. NC_017161.1.

Genome annotation databases

EnsemblBacteriaiADO45151; ADO45151; Hydth_0754.
BAI69214; BAI69214; HTH_0754.
GeneIDi12100895.
8773948.
KEGGihte:Hydth_0754.
hth:HTH_0754.
PATRICi32210403. VBIHydThe36152_0761.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002221 Genomic DNA. Translation: ADO45151.1 .
AP011112 Genomic DNA. Translation: BAI69214.1 .
RefSeqi WP_012963395.1. NC_017161.1.
YP_003432415.1. NC_013799.1.
YP_005511444.1. NC_017161.1.

3D structure databases

ProteinModelPortali D3DHB2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADO45151 ; ADO45151 ; Hydth_0754 .
BAI69214 ; BAI69214 ; HTH_0754 .
GeneIDi 12100895.
8773948.
KEGGi hte:Hydth_0754.
hth:HTH_0754.
PATRICi 32210403. VBIHydThe36152_0761.

Phylogenomic databases

HOGENOMi HOG000031444.
KOi K01775.
OMAi AEININN.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the thermophilic, obligately chemolithoautotrophic hydrogen-oxidizing bacterium Hydrogenobacter thermophilus TK-6."
    Arai H., Kanbe H., Ishii M., Igarashi Y.
    J. Bacteriol. 192:2651-2652(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 6534 / IAM 12695 / TK-6 [Tokyo] and TK-6.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 6534 / IAM 12695 / TK-6 [JGI] and TK-6Imported.

Entry informationi

Entry nameiD3DHB2_HYDTT
AccessioniPrimary (citable) accession number: D3DHB2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: September 3, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi