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D3DHB2

- D3DHB2_HYDTT

UniProt

D3DHB2 - D3DHB2_HYDTT

Protein

Alanine racemase

Gene

alr

Organism
Hydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (23 Mar 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei33 – 331Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei126 – 1261SubstrateUniRule annotation
    Active sitei236 – 2361Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei284 – 2841Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    Ordered Locus Names:HTH_0754Imported, Hydth_0754Imported
    OrganismiHydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6)Imported
    Taxonomic identifieri608538 [NCBI]
    Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeHydrogenobacter
    ProteomesiUP000008982: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei33 – 331N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD3DHB2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000031444.
    KOiK01775.
    OMAiAEININN.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D3DHB2-1 [UniParc]FASTAAdd to Basket

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    MARAVLEIDA DAIRQNIKAI RDFSGKRVIA VVKADAYGIG AVHICPILEA    50
    LDEVSSFAVA CVEEGIELRK AGIKKDILIL GGVFKGERKA LIEYALTPVV 100
    SHEAHLRAIE GLDIGFHVKY DTGMGRLGFF EDVLIKDRRV KGVLTHLSSP 150
    LDKDFSLMQI EKFKKIVKAY SNVDIHLESS AGIVYMVPFA THVRIGLAMY 200
    GEKPAPDYPI ELKRAISIKA RILSVKYLPP SYPVSYSRTF ITDRKKKVGV 250
    VAFGYADGLA KALSNVGCLY WKDKPLRILG NITMDMTMVD LDDTDAQVGD 300
    EVEVVGPHQS FSHLAKLAGT IPYEIMCHLS SRIKRVVV 338
    Length:338
    Mass (Da):37,315
    Last modified:March 23, 2010 - v1
    Checksum:iDD077B82BA883592
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002221 Genomic DNA. Translation: ADO45151.1.
    AP011112 Genomic DNA. Translation: BAI69214.1.
    RefSeqiWP_012963395.1. NC_017161.1.
    YP_003432415.1. NC_013799.1.
    YP_005511444.1. NC_017161.1.

    Genome annotation databases

    EnsemblBacteriaiADO45151; ADO45151; Hydth_0754.
    BAI69214; BAI69214; HTH_0754.
    GeneIDi12100895.
    8773948.
    KEGGihte:Hydth_0754.
    hth:HTH_0754.
    PATRICi32210403. VBIHydThe36152_0761.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002221 Genomic DNA. Translation: ADO45151.1 .
    AP011112 Genomic DNA. Translation: BAI69214.1 .
    RefSeqi WP_012963395.1. NC_017161.1.
    YP_003432415.1. NC_013799.1.
    YP_005511444.1. NC_017161.1.

    3D structure databases

    ProteinModelPortali D3DHB2.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADO45151 ; ADO45151 ; Hydth_0754 .
    BAI69214 ; BAI69214 ; HTH_0754 .
    GeneIDi 12100895.
    8773948.
    KEGGi hte:Hydth_0754.
    hth:HTH_0754.
    PATRICi 32210403. VBIHydThe36152_0761.

    Phylogenomic databases

    HOGENOMi HOG000031444.
    KOi K01775.
    OMAi AEININN.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the thermophilic, obligately chemolithoautotrophic hydrogen-oxidizing bacterium Hydrogenobacter thermophilus TK-6."
      Arai H., Kanbe H., Ishii M., Igarashi Y.
      J. Bacteriol. 192:2651-2652(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TK-6.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 6534 / IAM 12695 / TK-6 [JGI]Imported and TK-6Imported.

    Entry informationi

    Entry nameiD3DHB2_HYDTT
    AccessioniPrimary (citable) accession number: D3DHB2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 23, 2010
    Last sequence update: March 23, 2010
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3