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Protein

Alanine racemase

Gene

alr

Organism
Hydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:HTH_0754Imported
OrganismiHydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6)Imported
Taxonomic identifieri608538 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeHydrogenobacter
ProteomesiUP000002574 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi608538.HTH_0754.

Structurei

3D structure databases

ProteinModelPortaliD3DHB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini215 – 338124Ala_racemase_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787. LUCA.
ENOG4105CJ4. Bacteria.
HOGENOMiHOG000031444.
KOiK01775.
OMAiPSDWVRP.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3DHB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARAVLEIDA DAIRQNIKAI RDFSGKRVIA VVKADAYGIG AVHICPILEA
60 70 80 90 100
LDEVSSFAVA CVEEGIELRK AGIKKDILIL GGVFKGERKA LIEYALTPVV
110 120 130 140 150
SHEAHLRAIE GLDIGFHVKY DTGMGRLGFF EDVLIKDRRV KGVLTHLSSP
160 170 180 190 200
LDKDFSLMQI EKFKKIVKAY SNVDIHLESS AGIVYMVPFA THVRIGLAMY
210 220 230 240 250
GEKPAPDYPI ELKRAISIKA RILSVKYLPP SYPVSYSRTF ITDRKKKVGV
260 270 280 290 300
VAFGYADGLA KALSNVGCLY WKDKPLRILG NITMDMTMVD LDDTDAQVGD
310 320 330
EVEVVGPHQS FSHLAKLAGT IPYEIMCHLS SRIKRVVV
Length:338
Mass (Da):37,315
Last modified:March 23, 2010 - v1
Checksum:iDD077B82BA883592
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011112 Genomic DNA. Translation: BAI69214.1.
RefSeqiWP_012963395.1. NC_017161.1.

Genome annotation databases

EnsemblBacteriaiBAI69214; BAI69214; HTH_0754.
KEGGihte:Hydth_0754.
hth:HTH_0754.
PATRICi32210403. VBIHydThe36152_0761.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011112 Genomic DNA. Translation: BAI69214.1.
RefSeqiWP_012963395.1. NC_017161.1.

3D structure databases

ProteinModelPortaliD3DHB2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi608538.HTH_0754.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAI69214; BAI69214; HTH_0754.
KEGGihte:Hydth_0754.
hth:HTH_0754.
PATRICi32210403. VBIHydThe36152_0761.

Phylogenomic databases

eggNOGiCOG0787. LUCA.
ENOG4105CJ4. Bacteria.
HOGENOMiHOG000031444.
KOiK01775.
OMAiPSDWVRP.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the thermophilic, obligately chemolithoautotrophic hydrogen-oxidizing bacterium Hydrogenobacter thermophilus TK-6."
    Arai H., Kanbe H., Ishii M., Igarashi Y.
    J. Bacteriol. 192:2651-2652(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 6534 / IAM 12695 / TK-6 [Tokyo]Imported.

Entry informationi

Entry nameiD3DHB2_HYDTT
AccessioniPrimary (citable) accession number: D3DHB2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: January 20, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.