D3DHB2 (D3DHB2_HYDTT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Alanine racemase RuleBase RU000608
EC=5.1.1.1 RuleBase RU000608

Gene names

Name:	alr EMBL BAI69214.1
Ordered Locus Names:	HTH_0754, Hydth_0754

Organism

Hydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6) [Complete proteome] [HAMAP]

Taxonomic identifier

608538 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Aquificae › Aquificae › Aquificales › Aquificaceae › Hydrogenobacter › Hydrogenobacter thermophilus

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-alanine = D-alanine. SAAS SAAS020622
Cofactor	Pyridoxal phosphate By similarity. SAAS SAAS020622
Pathway	Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. RuleBase RU004247 SAAS SAAS020622
Sequence similarities	Belongs to the alanine racemase family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate SAAS SAAS020622
Molecular function	Isomerase SAAS SAAS020622 EMBL ADO45151.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	D-alanine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	alanine racemase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	D3DHB2 [UniParc]. Last modified March 23, 2010. Version 1. Checksum: DD077B82BA883592	FASTA	338	37,315
	10 20 30 40 50 60 MARAVLEIDA DAIRQNIKAI RDFSGKRVIA VVKADAYGIG AVHICPILEA LDEVSSFAVA 70 80 90 100 110 120 CVEEGIELRK AGIKKDILIL GGVFKGERKA LIEYALTPVV SHEAHLRAIE GLDIGFHVKY 130 140 150 160 170 180 DTGMGRLGFF EDVLIKDRRV KGVLTHLSSP LDKDFSLMQI EKFKKIVKAY SNVDIHLESS 190 200 210 220 230 240 AGIVYMVPFA THVRIGLAMY GEKPAPDYPI ELKRAISIKA RILSVKYLPP SYPVSYSRTF 250 260 270 280 290 300 ITDRKKKVGV VAFGYADGLA KALSNVGCLY WKDKPLRILG NITMDMTMVD LDDTDAQVGD 310 320 330 EVEVVGPHQS FSHLAKLAGT IPYEIMCHLS SRIKRVVV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of the thermophilic, obligately chemolithoautotrophic hydrogen-oxidizing bacterium Hydrogenobacter thermophilus TK-6." Arai H., Kanbe H., Ishii M., Igarashi Y. J. Bacteriol. 192:2651-2652(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 6534 / IAM 12695 / TK-6 [Tokyo] and TK-6.
[2]	"The complete genome of Hydrogenobacter thermophilus DSM 6534." US DOE Joint Genome Institute (JGI-PGF) Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N., Ovchinnikova G., Zeytun A., Detter J.C., Tapia R., Han C., Larimer F. , Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Wirth R., Klenk H.-P., Eisen J.A. Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: TK-6.
[3]	"Complete genome sequence of Hydrogenobacter thermophilus type strain (TK-6)." US DOE Joint Genome Institute (JGI-PGF) Zeytun A., Sikorski J., Nolan M., Lapidus A., Lucas S., Han J., Tice H., Cheng J., Tapia R., Goodwin L., Pitluck S., Liolios K., Ivanova N., Mavromatis K., Mikhailova N., Ovchinnikova G., Pati A., Chen A. , Palaniappan K., Ngatchou O., Land M., Hauser L., Chang Y., Jeffries C., Han C., Detter J., Ubler S., Rohde M., Tindall B., Wirth R., Woyke T., Bristow J., Eisen J., Markowitz V., Hugenholtz P., Klenk H., Kyrpides N. Stand. Genomic Sci. 4:131-143(2011) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 6534 / IAM 12695 / TK-6 [JGI].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP002221 Genomic DNA. Translation: ADO45151.1. AP011112 Genomic DNA. Translation: BAI69214.1.
RefSeq	YP_003432415.1. NC_013799.1. YP_005511444.1. NC_017161.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADO45151; ADO45151; Hydth_0754. BAI69214; BAI69214; HTH_0754.
GeneID	12100895. 8773948.
KEGG	hte:Hydth_0754. hth:HTH_0754.
PATRIC	32210403. VBIHydThe36152_0761.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000031444.
KO	K01775.
OMA	FKADKDM.
Enzyme and pathway databases
UniPathway	UPA00042; UER00497.
Family and domain databases
Gene3D	2.40.37.10. 1 hit.
HAMAP	MF_01201. Ala_racemase.
InterPro	IPR000821. Ala_racemase. IPR009006. Ala_racemase/Decarboxylase_C. IPR011079. Ala_racemase_C. IPR001608. Ala_racemase_N. IPR020622. Ala_racemase_pyridoxalP-BS. [Graphical view]
Pfam	PF00842. Ala_racemase_C. 1 hit. PF01168. Ala_racemase_N. 1 hit. [Graphical view]
PRINTS	PR00992. ALARACEMASE.
SMART	SM01005. Ala_racemase_C. 1 hit. [Graphical view]
SUPFAM	SSF50621. Racem_decarbox_C. 1 hit.
TIGRFAMs	TIGR00492. alr. 1 hit.
PROSITE	PS00395. ALANINE_RACEMASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

D3DHB2_HYDTT

Accession

Primary (citable) accession number: D3DHB2

Entry history

Integrated into UniProtKB/TrEMBL:	March 23, 2010
Last sequence update:	March 23, 2010
Last modified:	May 1, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)