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D3DHB2

- D3DHB2_HYDTT

UniProt

D3DHB2 - D3DHB2_HYDTT

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Protein

Alanine racemase

Gene

alr

Organism
Hydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei33 – 331Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei126 – 1261SubstrateUniRule annotation
Active sitei236 – 2361Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei284 – 2841Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:HTH_0754Imported, Hydth_0754Imported
OrganismiHydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6)Imported
Taxonomic identifieri608538 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeHydrogenobacter
ProteomesiUP000008982: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD3DHB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiAEININN.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D3DHB2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARAVLEIDA DAIRQNIKAI RDFSGKRVIA VVKADAYGIG AVHICPILEA
60 70 80 90 100
LDEVSSFAVA CVEEGIELRK AGIKKDILIL GGVFKGERKA LIEYALTPVV
110 120 130 140 150
SHEAHLRAIE GLDIGFHVKY DTGMGRLGFF EDVLIKDRRV KGVLTHLSSP
160 170 180 190 200
LDKDFSLMQI EKFKKIVKAY SNVDIHLESS AGIVYMVPFA THVRIGLAMY
210 220 230 240 250
GEKPAPDYPI ELKRAISIKA RILSVKYLPP SYPVSYSRTF ITDRKKKVGV
260 270 280 290 300
VAFGYADGLA KALSNVGCLY WKDKPLRILG NITMDMTMVD LDDTDAQVGD
310 320 330
EVEVVGPHQS FSHLAKLAGT IPYEIMCHLS SRIKRVVV
Length:338
Mass (Da):37,315
Last modified:March 23, 2010 - v1
Checksum:iDD077B82BA883592
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002221 Genomic DNA. Translation: ADO45151.1.
AP011112 Genomic DNA. Translation: BAI69214.1.
RefSeqiWP_012963395.1. NC_017161.1.
YP_003432415.1. NC_013799.1.
YP_005511444.1. NC_017161.1.

Genome annotation databases

EnsemblBacteriaiADO45151; ADO45151; Hydth_0754.
BAI69214; BAI69214; HTH_0754.
GeneIDi12100895.
8773948.
KEGGihte:Hydth_0754.
hth:HTH_0754.
PATRICi32210403. VBIHydThe36152_0761.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002221 Genomic DNA. Translation: ADO45151.1 .
AP011112 Genomic DNA. Translation: BAI69214.1 .
RefSeqi WP_012963395.1. NC_017161.1.
YP_003432415.1. NC_013799.1.
YP_005511444.1. NC_017161.1.

3D structure databases

ProteinModelPortali D3DHB2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADO45151 ; ADO45151 ; Hydth_0754 .
BAI69214 ; BAI69214 ; HTH_0754 .
GeneIDi 12100895.
8773948.
KEGGi hte:Hydth_0754.
hth:HTH_0754.
PATRICi 32210403. VBIHydThe36152_0761.

Phylogenomic databases

HOGENOMi HOG000031444.
KOi K01775.
OMAi AEININN.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the thermophilic, obligately chemolithoautotrophic hydrogen-oxidizing bacterium Hydrogenobacter thermophilus TK-6."
    Arai H., Kanbe H., Ishii M., Igarashi Y.
    J. Bacteriol. 192:2651-2652(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TK-6.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 6534 / IAM 12695 / TK-6 [JGI]Imported and TK-6Imported.

Entry informationi

Entry nameiD3DHB2_HYDTT
AccessioniPrimary (citable) accession number: D3DHB2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: November 26, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3