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D2YW48

- GST_COCIM

UniProt

D2YW48 - GST_COCIM

Protein

Probable glutathione S-transferase

Gene

CIMG_01314

Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 2 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Probable glutathione S-transferase.

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei14 – 141Glutathione1 Publication
    Binding sitei43 – 431Glutathione1 Publication
    Binding sitei57 – 571Glutathione; via amide nitrogen and carbonyl oxygen1 Publication
    Binding sitei124 – 1241Glutathione1 Publication

    GO - Molecular functioni

    1. glutathione transferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. aromatic amino acid family metabolic process Source: InterPro

    Keywords - Molecular functioni

    Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glutathione S-transferase (EC:2.5.1.18)
    Gene namesi
    ORF Names:CIMG_01314
    OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)
    Taxonomic identifieri246410 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
    ProteomesiUP000001261: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 231231Probable glutathione S-transferasePRO_0000404254Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Structurei

    Secondary structure

    1
    231
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi5 – 106
    Helixi15 – 2612
    Beta strandi32 – 354
    Helixi38 – 403
    Helixi42 – 443
    Helixi46 – 516
    Beta strandi53 – 553
    Beta strandi59 – 657
    Beta strandi68 – 703
    Beta strandi74 – 785
    Helixi81 – 9111
    Helixi106 – 12217
    Helixi125 – 1273
    Helixi129 – 1379
    Helixi142 – 16423
    Beta strandi165 – 1717
    Helixi176 – 19015
    Helixi195 – 1973
    Helixi199 – 20911
    Helixi212 – 2165
    Helixi219 – 2213
    Helixi227 – 2293

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3LG6X-ray2.20A/B/C/D1-231[»]
    3N5OX-ray1.85A/B1-231[»]
    ProteinModelPortaliD2YW48.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiD2YW48.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 9693GST N-terminalAdd
    BLAST
    Domaini105 – 227123GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni80 – 812Glutathione binding
    Regioni128 – 1303Glutathione binding

    Sequence similaritiesi

    Belongs to the GST superfamily. Zeta family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    KOiK01783.
    K01800.
    OrthoDBiEOG7TBCD0.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR005955. Mal_ac_isom.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF13417. GST_N_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    TIGRFAMsiTIGR01262. maiA. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D2YW48-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTPNFELYG YFRSSCSGRL RIAFHLKSIP YTRHPVNLLK GEQHSDTYKS    50
    LNPTNTVPLL VVSNINNTVS PSSASFSIGQ SLAALEYLEE ALPTNARPLL 100
    PPISNPVARA HVRTICNIIA CDVQPVTNLK IQKKVKALDG DPTVWSRDLA 150
    TQGFGAVEKL LELSAGRFCV GDEITLADVC LVPAVWAAER VGMDLARFPI 200
    TKRVFEEMLK EEAVQKAHWQ KQEDTPEDLR A 231
    Length:231
    Mass (Da):25,585
    Last modified:February 8, 2011 - v2
    Checksum:i6D6D57E813D63A07
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG704911 Genomic DNA. Translation: EAS36059.2.
    RefSeqiXP_001247543.1. XM_001247542.1.
    XP_001247642.1. XM_001247641.1.

    Genome annotation databases

    GeneIDi4567107.
    4567214.
    KEGGicim:CIMG_01314.
    cim:CIMG_01413.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG704911 Genomic DNA. Translation: EAS36059.2 .
    RefSeqi XP_001247543.1. XM_001247542.1.
    XP_001247642.1. XM_001247641.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3LG6 X-ray 2.20 A/B/C/D 1-231 [» ]
    3N5O X-ray 1.85 A/B 1-231 [» ]
    ProteinModelPortali D2YW48.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4567107.
    4567214.
    KEGGi cim:CIMG_01314.
    cim:CIMG_01413.

    Phylogenomic databases

    KOi K01783.
    K01800.
    OrthoDBi EOG7TBCD0.

    Miscellaneous databases

    EvolutionaryTracei D2YW48.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR005955. Mal_ac_isom.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF13417. GST_N_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    TIGRFAMsi TIGR01262. maiA. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RS.
    2. Cited for: GENOME REANNOTATION.
      Strain: RS.
    3. "Crystal structure of putative glutathione transferase from Coccidioides immitis bound to glutathione."
      Seattle structural genomics center for infectious disease (SSGCID)
      Submitted (JUN-2010) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) IN COMPLEX WITH GLUTATHIONE.
      Strain: RS.

    Entry informationi

    Entry nameiGST_COCIM
    AccessioniPrimary (citable) accession number: D2YW48
    Secondary accession number(s): J3KJ57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 8, 2011
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 32 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3