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D2YW48

- GST_COCIM

UniProt

D2YW48 - GST_COCIM

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Protein

Probable glutathione S-transferase

Gene
CIMG_01314
Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Probable glutathione S-transferase.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei14 – 141Glutathione
Binding sitei43 – 431Glutathione
Binding sitei57 – 571Glutathione; via amide nitrogen and carbonyl oxygen
Binding sitei124 – 1241Glutathione

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC

GO - Biological processi

  1. aromatic amino acid family metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione S-transferase (EC:2.5.1.18)
Gene namesi
ORF Names:CIMG_01314
OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)
Taxonomic identifieri246410 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000001261: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 231231Probable glutathione S-transferasePRO_0000404254Add
BLAST

Interactioni

Subunit structurei

Homodimer Inferred.

Structurei

Secondary structure

1
231
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 106
Helixi15 – 2612
Beta strandi32 – 354
Helixi38 – 403
Helixi42 – 443
Helixi46 – 516
Beta strandi53 – 553
Beta strandi59 – 657
Beta strandi68 – 703
Beta strandi74 – 785
Helixi81 – 9111
Helixi106 – 12217
Helixi125 – 1273
Helixi129 – 1379
Helixi142 – 16423
Beta strandi165 – 1717
Helixi176 – 19015
Helixi195 – 1973
Helixi199 – 20911
Helixi212 – 2165
Helixi219 – 2213
Helixi227 – 2293

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3LG6X-ray2.20A/B/C/D1-231[»]
3N5OX-ray1.85A/B1-231[»]
ProteinModelPortaliD2YW48.

Miscellaneous databases

EvolutionaryTraceiD2YW48.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 9693GST N-terminalAdd
BLAST
Domaini105 – 227123GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni80 – 812Glutathione binding
Regioni128 – 1303Glutathione binding

Sequence similaritiesi

Belongs to the GST superfamily. Zeta family.

Phylogenomic databases

KOiK01783.
K01800.
OrthoDBiEOG7TBCD0.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR005955. Mal_ac_isom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01262. maiA. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D2YW48-1 [UniParc]FASTAAdd to Basket

« Hide

MTTPNFELYG YFRSSCSGRL RIAFHLKSIP YTRHPVNLLK GEQHSDTYKS    50
LNPTNTVPLL VVSNINNTVS PSSASFSIGQ SLAALEYLEE ALPTNARPLL 100
PPISNPVARA HVRTICNIIA CDVQPVTNLK IQKKVKALDG DPTVWSRDLA 150
TQGFGAVEKL LELSAGRFCV GDEITLADVC LVPAVWAAER VGMDLARFPI 200
TKRVFEEMLK EEAVQKAHWQ KQEDTPEDLR A 231
Length:231
Mass (Da):25,585
Last modified:February 8, 2011 - v2
Checksum:i6D6D57E813D63A07
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG704911 Genomic DNA. Translation: EAS36059.2.
RefSeqiXP_001247543.1. XM_001247542.1.
XP_001247642.1. XM_001247641.1.

Genome annotation databases

GeneIDi4567107.
4567214.
KEGGicim:CIMG_01314.
cim:CIMG_01413.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG704911 Genomic DNA. Translation: EAS36059.2 .
RefSeqi XP_001247543.1. XM_001247542.1.
XP_001247642.1. XM_001247641.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3LG6 X-ray 2.20 A/B/C/D 1-231 [» ]
3N5O X-ray 1.85 A/B 1-231 [» ]
ProteinModelPortali D2YW48.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4567107.
4567214.
KEGGi cim:CIMG_01314.
cim:CIMG_01413.

Phylogenomic databases

KOi K01783.
K01800.
OrthoDBi EOG7TBCD0.

Miscellaneous databases

EvolutionaryTracei D2YW48.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR005955. Mal_ac_isom.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsi TIGR01262. maiA. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RS.
  2. Cited for: GENOME REANNOTATION.
    Strain: RS.
  3. "Crystal structure of putative glutathione transferase from Coccidioides immitis bound to glutathione."
    Seattle structural genomics center for infectious disease (SSGCID)
    Submitted (JUN-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) IN COMPLEX WITH GLUTATHIONE.
    Strain: RS.

Entry informationi

Entry nameiGST_COCIM
AccessioniPrimary (citable) accession number: D2YW48
Secondary accession number(s): J3KJ57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: February 8, 2011
Last modified: November 13, 2013
This is version 31 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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