Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable glutathione S-transferase

Gene

CIMG_01314

Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable glutathione S-transferase.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei14Glutathione1 Publication1
Binding sitei43Glutathione1 Publication1
Binding sitei57Glutathione; via amide nitrogen and carbonyl oxygen1 Publication1
Binding sitei124Glutathione1 Publication1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione S-transferase (EC:2.5.1.18)
Gene namesi
ORF Names:CIMG_01314
OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)
Taxonomic identifieri246410 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenales incertae sedisCoccidioides
Proteomesi
  • UP000001261 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:CIMG_01314.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004042541 – 231Probable glutathione S-transferaseAdd BLAST231

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi246410.XP_001247543.1.

Structurei

Secondary structure

1231
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 10Combined sources6
Helixi15 – 26Combined sources12
Beta strandi32 – 35Combined sources4
Helixi38 – 40Combined sources3
Helixi42 – 44Combined sources3
Helixi46 – 51Combined sources6
Beta strandi53 – 55Combined sources3
Beta strandi59 – 65Combined sources7
Beta strandi68 – 70Combined sources3
Beta strandi74 – 78Combined sources5
Helixi81 – 91Combined sources11
Helixi106 – 122Combined sources17
Helixi125 – 127Combined sources3
Helixi129 – 137Combined sources9
Helixi142 – 164Combined sources23
Beta strandi165 – 171Combined sources7
Helixi176 – 190Combined sources15
Helixi195 – 197Combined sources3
Helixi199 – 209Combined sources11
Helixi212 – 216Combined sources5
Helixi219 – 221Combined sources3
Helixi227 – 229Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LG6X-ray2.20A/B/C/D1-231[»]
3N5OX-ray1.85A/B1-231[»]
ProteinModelPortaliD2YW48.
SMRiD2YW48.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiD2YW48.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 96GST N-terminalAdd BLAST93
Domaini105 – 227GST C-terminalAdd BLAST123

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni80 – 81Glutathione binding2
Regioni128 – 130Glutathione binding3

Sequence similaritiesi

Belongs to the GST superfamily. Zeta family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiENOG410J2T5. Eukaryota.
KOG0868. Eukaryota.
COG0625. LUCA.
ENOG410YE75. LUCA.
InParanoidiD2YW48.
KOiK01800.
OrthoDBiEOG092C5GXZ.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR005955. Mal_ac_isom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF14497. GST_C_3. 1 hit.
PF13409. GST_N_2. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01262. maiA. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D2YW48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTPNFELYG YFRSSCSGRL RIAFHLKSIP YTRHPVNLLK GEQHSDTYKS
60 70 80 90 100
LNPTNTVPLL VVSNINNTVS PSSASFSIGQ SLAALEYLEE ALPTNARPLL
110 120 130 140 150
PPISNPVARA HVRTICNIIA CDVQPVTNLK IQKKVKALDG DPTVWSRDLA
160 170 180 190 200
TQGFGAVEKL LELSAGRFCV GDEITLADVC LVPAVWAAER VGMDLARFPI
210 220 230
TKRVFEEMLK EEAVQKAHWQ KQEDTPEDLR A
Length:231
Mass (Da):25,585
Last modified:February 8, 2011 - v2
Checksum:i6D6D57E813D63A07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG704911 Genomic DNA. Translation: EAS35960.3.
RefSeqiXP_001247543.1. XM_001247542.2.

Genome annotation databases

EnsemblFungiiEAS35960; EAS35960; CIMG_01314.
GeneIDi4567107.
KEGGicim:CIMG_01314.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG704911 Genomic DNA. Translation: EAS35960.3.
RefSeqiXP_001247543.1. XM_001247542.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LG6X-ray2.20A/B/C/D1-231[»]
3N5OX-ray1.85A/B1-231[»]
ProteinModelPortaliD2YW48.
SMRiD2YW48.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246410.XP_001247543.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAS35960; EAS35960; CIMG_01314.
GeneIDi4567107.
KEGGicim:CIMG_01314.

Organism-specific databases

EuPathDBiFungiDB:CIMG_01314.

Phylogenomic databases

eggNOGiENOG410J2T5. Eukaryota.
KOG0868. Eukaryota.
COG0625. LUCA.
ENOG410YE75. LUCA.
InParanoidiD2YW48.
KOiK01800.
OrthoDBiEOG092C5GXZ.

Miscellaneous databases

EvolutionaryTraceiD2YW48.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR005955. Mal_ac_isom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF14497. GST_C_3. 1 hit.
PF13409. GST_N_2. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01262. maiA. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGST_COCIM
AccessioniPrimary (citable) accession number: D2YW48
Secondary accession number(s): J3KIY1, J3KJ57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: February 8, 2011
Last modified: November 2, 2016
This is version 45 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.