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D2YW48

- GST_COCIM

UniProt

D2YW48 - GST_COCIM

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Protein

Probable glutathione S-transferase

Gene

CIMG_01314

Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Probable glutathione S-transferase.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei14 – 141Glutathione1 Publication
Binding sitei43 – 431Glutathione1 Publication
Binding sitei57 – 571Glutathione; via amide nitrogen and carbonyl oxygen1 Publication
Binding sitei124 – 1241Glutathione1 Publication

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC

GO - Biological processi

  1. aromatic amino acid family metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione S-transferase (EC:2.5.1.18)
Gene namesi
ORF Names:CIMG_01314
OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)
Taxonomic identifieri246410 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000001261: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 231231Probable glutathione S-transferasePRO_0000404254Add
BLAST

Interactioni

Subunit structurei

Homodimer.1 Publication

Structurei

Secondary structure

1
231
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 106Combined sources
Helixi15 – 2612Combined sources
Beta strandi32 – 354Combined sources
Helixi38 – 403Combined sources
Helixi42 – 443Combined sources
Helixi46 – 516Combined sources
Beta strandi53 – 553Combined sources
Beta strandi59 – 657Combined sources
Beta strandi68 – 703Combined sources
Beta strandi74 – 785Combined sources
Helixi81 – 9111Combined sources
Helixi106 – 12217Combined sources
Helixi125 – 1273Combined sources
Helixi129 – 1379Combined sources
Helixi142 – 16423Combined sources
Beta strandi165 – 1717Combined sources
Helixi176 – 19015Combined sources
Helixi195 – 1973Combined sources
Helixi199 – 20911Combined sources
Helixi212 – 2165Combined sources
Helixi219 – 2213Combined sources
Helixi227 – 2293Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3LG6X-ray2.20A/B/C/D1-231[»]
3N5OX-ray1.85A/B1-231[»]
ProteinModelPortaliD2YW48.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiD2YW48.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 9693GST N-terminalAdd
BLAST
Domaini105 – 227123GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni80 – 812Glutathione binding
Regioni128 – 1303Glutathione binding

Sequence similaritiesi

Belongs to the GST superfamily. Zeta family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

InParanoidiD2YW48.
KOiK01783.
K01800.
OrthoDBiEOG7TBCD0.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR005955. Mal_ac_isom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01262. maiA. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D2YW48-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTPNFELYG YFRSSCSGRL RIAFHLKSIP YTRHPVNLLK GEQHSDTYKS
60 70 80 90 100
LNPTNTVPLL VVSNINNTVS PSSASFSIGQ SLAALEYLEE ALPTNARPLL
110 120 130 140 150
PPISNPVARA HVRTICNIIA CDVQPVTNLK IQKKVKALDG DPTVWSRDLA
160 170 180 190 200
TQGFGAVEKL LELSAGRFCV GDEITLADVC LVPAVWAAER VGMDLARFPI
210 220 230
TKRVFEEMLK EEAVQKAHWQ KQEDTPEDLR A
Length:231
Mass (Da):25,585
Last modified:February 8, 2011 - v2
Checksum:i6D6D57E813D63A07
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG704911 Genomic DNA. Translation: EAS36059.2.
RefSeqiXP_001247543.1. XM_001247542.1.
XP_001247642.1. XM_001247641.1.

Genome annotation databases

GeneIDi4567107.
4567214.
KEGGicim:CIMG_01314.
cim:CIMG_01413.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG704911 Genomic DNA. Translation: EAS36059.2 .
RefSeqi XP_001247543.1. XM_001247542.1.
XP_001247642.1. XM_001247641.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3LG6 X-ray 2.20 A/B/C/D 1-231 [» ]
3N5O X-ray 1.85 A/B 1-231 [» ]
ProteinModelPortali D2YW48.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4567107.
4567214.
KEGGi cim:CIMG_01314.
cim:CIMG_01413.

Phylogenomic databases

InParanoidi D2YW48.
KOi K01783.
K01800.
OrthoDBi EOG7TBCD0.

Miscellaneous databases

EvolutionaryTracei D2YW48.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR005955. Mal_ac_isom.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsi TIGR01262. maiA. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RS.
  2. Cited for: GENOME REANNOTATION.
    Strain: RS.
  3. "Crystal structure of putative glutathione transferase from Coccidioides immitis bound to glutathione."
    Seattle structural genomics center for infectious disease (SSGCID)
    Submitted (JUN-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) IN COMPLEX WITH GLUTATHIONE.
    Strain: RS.

Entry informationi

Entry nameiGST_COCIM
AccessioniPrimary (citable) accession number: D2YW48
Secondary accession number(s): J3KJ57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: February 8, 2011
Last modified: October 29, 2014
This is version 33 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3