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D2YW48 (GST_COCIM) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glutathione S-transferase

EC=2.5.1.18
Gene names
ORF Names:CIMG_01314
OrganismCoccidioides immitis (strain RS) (Valley fever fungus) [Reference proteome]
Taxonomic identifier246410 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides

Protein attributes

Sequence length231 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable glutathione S-transferase.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homodimer Probable.

Sequence similarities

Belongs to the GST superfamily. Zeta family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Molecular functionTransferase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaromatic amino acid family metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 231231Probable glutathione S-transferase
PRO_0000404254

Regions

Domain4 – 9693GST N-terminal
Domain105 – 227123GST C-terminal
Region80 – 812Glutathione binding
Region128 – 1303Glutathione binding

Sites

Binding site141Glutathione
Binding site431Glutathione
Binding site571Glutathione; via amide nitrogen and carbonyl oxygen
Binding site1241Glutathione

Secondary structure

............................................ 231
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
D2YW48 [UniParc].

Last modified February 8, 2011. Version 2.
Checksum: 6D6D57E813D63A07

FASTA23125,585
        10         20         30         40         50         60 
MTTPNFELYG YFRSSCSGRL RIAFHLKSIP YTRHPVNLLK GEQHSDTYKS LNPTNTVPLL 

        70         80         90        100        110        120 
VVSNINNTVS PSSASFSIGQ SLAALEYLEE ALPTNARPLL PPISNPVARA HVRTICNIIA 

       130        140        150        160        170        180 
CDVQPVTNLK IQKKVKALDG DPTVWSRDLA TQGFGAVEKL LELSAGRFCV GDEITLADVC 

       190        200        210        220        230 
LVPAVWAAER VGMDLARFPI TKRVFEEMLK EEAVQKAHWQ KQEDTPEDLR A 

« Hide

References

« Hide 'large scale' references
[1]"Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives."
Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N. expand/collapse author list , Orbach M.J., Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W.
Genome Res. 19:1722-1731(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RS.
[2]"Population genomic sequencing of Coccidioides fungi reveals recent hybridization and transposon control."
Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J., Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D., Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A., FitzGerald M. expand/collapse author list , Lui A., Macdonald J.P., Priest M., Orbach M.J., Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R., Taylor J.W., Rounsley S.D.
Genome Res. 20:938-946(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: RS.
[3]"Crystal structure of putative glutathione transferase from Coccidioides immitis bound to glutathione."
Seattle structural genomics center for infectious disease (SSGCID)
Submitted (JUN-2010) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) IN COMPLEX WITH GLUTATHIONE.
Strain: RS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
GG704911 Genomic DNA. Translation: EAS36059.2.
RefSeqXP_001247543.1. XM_001247542.1.
XP_001247642.1. XM_001247641.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3LG6X-ray2.20A/B/C/D1-231[»]
3N5OX-ray1.85A/B1-231[»]
ProteinModelPortalD2YW48.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4567107.
4567214.
KEGGcim:CIMG_01314.
cim:CIMG_01413.

Phylogenomic databases

KOK01783.
K01800.
OrthoDBEOG7TBCD0.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR005955. Mal_ac_isom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsTIGR01262. maiA. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceD2YW48.

Entry information

Entry nameGST_COCIM
AccessionPrimary (citable) accession number: D2YW48
Secondary accession number(s): J3KJ57
Entry history
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: February 8, 2011
Last modified: November 13, 2013
This is version 31 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references