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Protein

GTP-binding protein 1

Gene

Gtpbp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi167 – 174GTPSequence analysis8
Nucleotide bindingi252 – 256GTPSequence analysis5
Nucleotide bindingi308 – 311GTPSequence analysis4

GO - Molecular functioni

  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB-KW
  • poly(A) RNA binding Source: Ensembl
  • translation elongation factor activity Source: GO_Central

GO - Biological processi

  • positive regulation of mRNA catabolic process Source: UniProtKB
  • translational elongation Source: GO_Central
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein 1
Gene namesi
Name:Gtpbp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1306758. Gtpbp1.

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

  • cytoplasmic exosome (RNase complex) Source: UniProtKB
  • cytosol Source: UniProtKB
  • membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi173 – 174KS → AA: Reduced decay of target mRNA. Slightly reduced GTPase activity. No effect on GTP binding. 1 Publication2
Mutagenesisi173K → A: Reduced decay of target mRNA. No effect on GTP binding. 1 Publication1
Mutagenesisi173K → E: Reduced decay of target mRNA. Reduced GTPase activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004124701 – 669GTP-binding protein 1Add BLAST669

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineBy similarity1
Modified residuei8PhosphoserineBy similarity1
Modified residuei12PhosphoserineCombined sources1
Modified residuei24PhosphoserineBy similarity1
Modified residuei25PhosphoserineBy similarity1
Modified residuei44PhosphoserineCombined sources1
Modified residuei47PhosphoserineCombined sources1
Modified residuei69PhosphoserineCombined sources1
Modified residuei580PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiD2XV59.
PeptideAtlasiD2XV59.
PRIDEiD2XV59.

PTM databases

iPTMnetiD2XV59.
PhosphoSitePlusiD2XV59.

Expressioni

Tissue specificityi

Detected in pineal gland (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000014634.
GenevisibleiD2XV59. RN.

Interactioni

Subunit structurei

Interacts with EXOSC2/RRP4, EXOSC3/RRP40, EXOSC5/RRP46, HNRNPD, HNRNPR and SYNCRIP. Identified in a complex with HNRNPD, HNRNPL, HNRNPQ, HNRNPR, HNRNPU and AANAT mRNA, but does not bind mRNA by itself.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039165.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini158 – 389tr-type GPROSITE-ProRule annotationAdd BLAST232

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni167 – 174G1PROSITE-ProRule annotation8
Regioni206 – 210G2PROSITE-ProRule annotation5
Regioni252 – 255G3PROSITE-ProRule annotation4
Regioni308 – 311G4PROSITE-ProRule annotation4
Regioni366 – 368G5PROSITE-ProRule annotation3

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. GTPBP1 subfamily.PROSITE-ProRule annotation
Contains 1 tr-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0463. Eukaryota.
COG5258. LUCA.
GeneTreeiENSGT00730000110829.
HOGENOMiHOG000176635.
InParanoidiD2XV59.
OMAiPPGDEAC.
OrthoDBiEOG091G06LY.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D2XV59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAERSRSPV DSPVPASMFA PEPSSPGAAR AAAAAARLHG GFDSDCSEDG
60 70 80 90 100
EALNGEPELD LTSKLVLVSP TSEQYDSLLR QMWERMDEGC GETIYVIGQG
110 120 130 140 150
SDGTEYGLSE ADMEASYATV KSMAEQIEAD VILLRERQES GGRVRDYLVR
160 170 180 190 200
KRVGDNDFLE VRVAVVGNVD AGKSTLLGVL THGELDNGRG FARQKLFRHK
210 220 230 240 250
HEIESGRTSS VGNDILGFDS EGNVVNKPDS HGGSLEWTKI CEKSSKVITF
260 270 280 290 300
IDLAGHEKYL KTTVFGMTGH LPDFCMLMVG SNAGIVGMTK EHLGLALALN
310 320 330 340 350
VPVFVVVTKI DMCPANILQE TLKLLQRLLK SPGCRKIPVL VQSKDDVIVT
360 370 380 390 400
ASNFSSERMC PIFQISNVTG ENLDLLKMFL NLLSPRTSYR EEEPAEFQID
410 420 430 440 450
DTYSVPGVGT VVSGTTLRGL IKLNDTLLLG PDPLGNFLSI AVKSIHRKRM
460 470 480 490 500
PVKEVRGGQT ASFALKKIKR SSIRKGMVMV SPRLNPQASW EFEAEILVLH
510 520 530 540 550
HPTTISPRYQ AMVHCGSIRQ TATILSMDKD CLRTGDKATV HFRFIKTPEY
560 570 580 590 600
LHIDQRLVFR EGRTKAVGTI TKLLQTTNNS PMNSKPQQIK MQSTKKGPLS
610 620 630 640 650
KREEGGPSGV PAAGPPSTGD EASSLGTTQA ATSSGLQPQP KPSSGGRRRG
660
GQRHKVKSQG ACVTPASGC
Length:669
Mass (Da):72,489
Last modified:March 2, 2010 - v1
Checksum:i8A244D3E408E0197
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU256773 mRNA. Translation: ADB22435.1.
CH473950 Genomic DNA. Translation: EDM15787.1.
RefSeqiNP_001186244.1. NM_001199315.1.
UniGeneiRn.97210.

Genome annotation databases

EnsembliENSRNOT00000049247; ENSRNOP00000039165; ENSRNOG00000014634.
GeneIDi300077.
KEGGirno:300077.
UCSCiRGD:1306758. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU256773 mRNA. Translation: ADB22435.1.
CH473950 Genomic DNA. Translation: EDM15787.1.
RefSeqiNP_001186244.1. NM_001199315.1.
UniGeneiRn.97210.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039165.

PTM databases

iPTMnetiD2XV59.
PhosphoSitePlusiD2XV59.

Proteomic databases

PaxDbiD2XV59.
PeptideAtlasiD2XV59.
PRIDEiD2XV59.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000049247; ENSRNOP00000039165; ENSRNOG00000014634.
GeneIDi300077.
KEGGirno:300077.
UCSCiRGD:1306758. rat.

Organism-specific databases

CTDi9567.
RGDi1306758. Gtpbp1.

Phylogenomic databases

eggNOGiKOG0463. Eukaryota.
COG5258. LUCA.
GeneTreeiENSGT00730000110829.
HOGENOMiHOG000176635.
InParanoidiD2XV59.
OMAiPPGDEAC.
OrthoDBiEOG091G06LY.

Miscellaneous databases

PROiD2XV59.

Gene expression databases

BgeeiENSRNOG00000014634.
GenevisibleiD2XV59. RN.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGTPB1_RAT
AccessioniPrimary (citable) accession number: D2XV59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: March 2, 2010
Last modified: November 2, 2016
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.