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Protein

Imidazole glycerol phosphate synthase subunit HisH

Gene

hisH

Organism
Blochmannia floridanus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR.UniRule annotationSAAS annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + L-glutamine = imidazole-glycerol phosphate + 5-aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H2O.UniRule annotationSAAS annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI)
  4. 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamideisomerase (hisA), 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Histidine biosynthesis bifunctional protein HisB (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. Histidine biosynthesis bifunctional protein HisB (hisB)
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei77NucleophileUniRule annotation1
Active sitei178UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseImported, Transferase
Biological processAmino-acid biosynthesis, Histidine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00031; UER00010

Protein family/group databases

MEROPSiC26.965

Names & Taxonomyi

Protein namesi
Recommended name:
Imidazole glycerol phosphate synthase subunit HisHUniRule annotation (EC:2.4.2.-UniRule annotation)
Alternative name(s):
IGP synthase glutamine amidotransferase subunitUniRule annotation
IGP synthase subunit HisHUniRule annotation
ImGP synthase subunit HisHUniRule annotation
Short name:
IGPS subunit HisHUniRule annotation
Gene namesi
Name:hisHUniRule annotationImported
OrganismiBlochmannia floridanusImported
Taxonomic identifieri203907 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeant endosymbiontsCandidatus Blochmannia

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Heterodimer of HisH and HisF.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliD2XN34
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 196Glutamine amidotransferase type-1InterPro annotationAdd BLAST195

Keywords - Domaini

Glutamine amidotransferaseUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4108UJE Bacteria
COG0118 LUCA

Family and domain databases

CDDicd01748 GATase1_IGP_Synthase, 1 hit
Gene3Di3.40.50.8801 hit
HAMAPiMF_00278 HisH, 1 hit
InterProiView protein in InterPro
IPR029062 Class_I_gatase-like
IPR017926 GATASE
IPR010139 Imidazole-glycPsynth_HisH
PANTHERiPTHR42701 PTHR42701, 1 hit
PfamiView protein in Pfam
PF00117 GATase, 1 hit
PIRSFiPIRSF000495 Amidotransf_hisH, 1 hit
SUPFAMiSSF52317 SSF52317, 1 hit
TIGRFAMsiTIGR01855 IMP_synth_hisH, 1 hit
PROSITEiView protein in PROSITE
PS51273 GATASE_TYPE_1, 1 hit

Sequencei

Sequence statusi: Complete.

D2XN34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIIIINTNC SNLSSVKIML NKLGCNTIIT DDPDLIIQSD KILLPGVGTA
60 70 80 90 100
NTAMKQLKKK NLIQLIKKCT QPTLGICLGM QLFGSFSNEN THTNTLNIIN
110 120 130 140 150
VPVKHMYSPT LPIPHMGWNN ITILKKHDLL NGINNNHYFY FAHSYCMELN
160 170 180 190
YTTIAYTNYG QPFSSVIVYK NFFGVQFHPK KSSFSGEQLI KNFLEI
Length:196
Mass (Da):22,176
Last modified:March 2, 2010 - v1
Checksum:iFC52BF5982608187
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU214045 Genomic DNA Translation: ADA82643.1

Similar proteinsi

Entry informationi

Entry nameiD2XN34_BLOFL
AccessioniPrimary (citable) accession number: D2XN34
Entry historyiIntegrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: December 20, 2017
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)