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D2WKD8

- AT1A2_PIG

UniProt

D2WKD8 - AT1A2_PIG

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Protein
Sodium/potassium-transporting ATPase subunit alpha-2
Gene
ATP1A2
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients By similarity.

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei374 – 37414-aspartylphosphate intermediate By similarity
Metal bindingi714 – 7141Magnesium By similarity
Metal bindingi718 – 7181Magnesium By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sodium:potassium-exchanging ATPase activity Source: UniProtKB-EC

GO - Biological processi

  1. ATP biosynthetic process Source: InterPro
  2. adult locomotory behavior Source: Ensembl
  3. locomotion Source: Ensembl
  4. negative regulation of cytosolic calcium ion concentration Source: Ensembl
  5. negative regulation of heart contraction Source: Ensembl
  6. negative regulation of striated muscle contraction Source: Ensembl
  7. neurotransmitter uptake Source: Ensembl
  8. regulation of blood pressure Source: Ensembl
  9. regulation of respiratory gaseous exchange by neurological system process Source: Ensembl
  10. regulation of smooth muscle contraction Source: Ensembl
  11. regulation of the force of heart contraction Source: Ensembl
  12. regulation of vasoconstriction Source: Ensembl
  13. visual learning Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Enzyme and pathway databases

ReactomeiREACT_209531. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-2 (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha-2 subunit
Alternative name(s):
Sodium pump subunit alpha-2
Gene namesi
Name:ATP1A2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 4

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini6 – 8580Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei86 – 10621Helical; Reviewed prediction
Add
BLAST
Topological domaini107 – 12923Extracellular Reviewed prediction
Add
BLAST
Transmembranei130 – 15021Helical; Reviewed prediction
Add
BLAST
Topological domaini151 – 286136Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei287 – 30620Helical; Reviewed prediction
Add
BLAST
Topological domaini307 – 31812Extracellular Reviewed prediction
Add
BLAST
Transmembranei319 – 33618Helical; Reviewed prediction
Add
BLAST
Topological domaini337 – 769433Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei770 – 78920Helical; Reviewed prediction
Add
BLAST
Topological domaini790 – 79910Extracellular Reviewed prediction
Transmembranei800 – 82021Helical; Reviewed prediction
Add
BLAST
Topological domaini821 – 84020Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei841 – 86323Helical; Reviewed prediction
Add
BLAST
Topological domaini864 – 91552Extracellular Reviewed prediction
Add
BLAST
Transmembranei916 – 93520Helical; Reviewed prediction
Add
BLAST
Topological domaini936 – 94813Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei949 – 96719Helical; Reviewed prediction
Add
BLAST
Topological domaini968 – 98215Extracellular Reviewed prediction
Add
BLAST
Transmembranei983 – 100321Helical; Reviewed prediction
Add
BLAST
Topological domaini1004 – 102017Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. T-tubule Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 55 By similarity
PRO_0000411080
Chaini6 – 10201015Sodium/potassium-transporting ATPase subunit alpha-2
PRO_0000411081Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei570 – 5701Phosphothreonine By similarity
Modified residuei587 – 5871Phosphoserine By similarity
Modified residuei940 – 9401Phosphoserine; by PKA By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma By similarity.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi385 – 3917
Beta strandi394 – 3974
Helixi414 – 42512
Helixi449 – 46214
Helixi465 – 4706
Beta strandi474 – 4785
Beta strandi487 – 4926
Beta strandi499 – 5068
Helixi508 – 5136
Beta strandi515 – 5206
Beta strandi523 – 5264
Helixi529 – 54416
Beta strandi548 – 55710
Turni559 – 5613
Turni570 – 5734
Beta strandi578 – 59013

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q3IX-ray2.60A384-590[»]
ProteinModelPortaliD2WKD8.

Miscellaneous databases

EvolutionaryTraceiD2WKD8.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni80 – 823Interaction with phosphoinositide-3 kinase By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00560000076866.
KOiK01539.
OMAiIINIPLP.
OrthoDBiEOG7327N0.
TreeFamiTF312838.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D2WKD8-1 [UniParc]FASTAAdd to Basket

« Hide

MGRGAGREYS PAATTAENGG GKKKQKEKEL DELKKEVAMD DHKLSLDELG     50
RKYQVDLSKG LTNQRAQDIL ARDGPNALTP PPTTPEWVKF CRQLFGGFSI 100
LLWIGAILCF LAYGIQAAME DEPSNDNLYL GVVLAAVVIV TGCFSYYQEA 150
KSSKIMDSFK NMVPQQALVV REGEKMQINA EEVVVGDLVE VKGGDRVPAD 200
LRIISSHGCK VDNSSLTGES EPQTRSPEFT HENPLETRNI CFFSTNCVEG 250
TARGIVIATG DRTVMGRIAT LASGLEVGRT PIAMEIEHFI QLITGVAVFL 300
GVSFFVLSLI LGYSWLEAVI FLIGIIVANV PEGLLATVTV CLTLTAKRMA 350
RKNCLVKNLE AVETLGSTST ICSDKTGTLT QNRMTVAHMW FDNQIHEADT 400
TEDQSGATFD KRSPTWTALS RIAGLCNRAV FKAGQENISV SKRDTAGDAS 450
ESALLKCIEL SCGSVRKMRD RNPKVAEIPF NSTNKYQLSI HEREDNPQSH 500
VLVMKGAPER ILDRCSSILV QGKEIPLDKE MQDAFQNAYL ELGGLGERVL 550
GFCQLNLPSG KFPRGFKFDT DELNFPTEKL CFVGLMSMID PPRAAVPDAV 600
GKCRSAGIKV IMVTGDHPIT AKAIAKGVGI ISEGNETVED IAARLNIPVS 650
QVNPREAKAC VVHGSDLKDM TSEQLDEILK NHTEIVFART SPQQKLIIVE 700
GCQRQGAIVA VTGDGVNDSP ALKKADIGIA MGIAGSDVSK QAADMILLDD 750
NFASIVTGVE EGRLIFDNLK KSIAYTLTSN IPEITPFLLF IIANIPLPLG 800
TVTILCIDLG TDMVPAISLA YEAAESDIMK RQPRNPQTDK LVNERLISMA 850
YGQIGMIQAL GGFFTYFVIL AENGFLPSRL LGIRLDWDDR SMNDLEDSYG 900
QEWTYEQRKV VEFTCHTAFF ASIVVVQWAD LIICKTRRNS VFQQGMKNKI 950
LIFGLLEETA LAAFLSYCPG MGVALRMYPL KVTWWFCAFP YSLLIFIYDE 1000
VRKLILRRYP GGWVEKETYY 1020
Length:1,020
Mass (Da):112,208
Last modified:March 2, 2010 - v1
Checksum:i0DFB46632BBA2E2D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GQ340776 mRNA. Translation: ADB19854.1.
CU138477 Genomic DNA. No translation available.
RefSeqiNP_001165012.1. NM_001171541.1.
UniGeneiSsc.14403.

Genome annotation databases

EnsembliENSSSCT00000007004; ENSSSCP00000006814; ENSSSCG00000006391.
GeneIDi396828.
KEGGissc:396828.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GQ340776 mRNA. Translation: ADB19854.1 .
CU138477 Genomic DNA. No translation available.
RefSeqi NP_001165012.1. NM_001171541.1.
UniGenei Ssc.14403.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1Q3I X-ray 2.60 A 384-590 [» ]
ProteinModelPortali D2WKD8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSSSCT00000007004 ; ENSSSCP00000006814 ; ENSSSCG00000006391 .
GeneIDi 396828.
KEGGi ssc:396828.

Organism-specific databases

CTDi 477.

Phylogenomic databases

GeneTreei ENSGT00560000076866.
KOi K01539.
OMAi IINIPLP.
OrthoDBi EOG7327N0.
TreeFami TF312838.

Enzyme and pathway databases

Reactomei REACT_209531. Ion transport by P-type ATPases.

Miscellaneous databases

EvolutionaryTracei D2WKD8.

Family and domain databases

Gene3Di 1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of Porcine ATP1A2 mRNA."
    Henriksen C., Bendixen C., Andersen J.P., Vilsen B., Larsen K.
    Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Porcine genome sequencing project
    Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The crystallographic structure of Na,K-ATPase N-domain at 2.6A resolution."
    Hakansson K.O.
    J. Mol. Biol. 332:1175-1182(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 384-590.

Entry informationi

Entry nameiAT1A2_PIG
AccessioniPrimary (citable) accession number: D2WKD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 2, 2010
Last modified: September 3, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi