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Protein

Thymidine kinase

Gene

NAEGRDRAFT_59882

Organism
Naegleria gruberi (Amoeba)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
ORF Names:NAEGRDRAFT_59882Imported
OrganismiNaegleria gruberi (Amoeba)Imported
Taxonomic identifieri5762 [NCBI]
Taxonomic lineageiEukaryotaHeteroloboseaSchizopyrenidaVahlkampfiidaeNaegleria
ProteomesiUP000006671: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliD2W1T6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

InParanoidiD2W1T6.
OMAiDNDIATH.

Family and domain databases

InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D2W1T6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDIATIEPS ATPSTPKKSS PKASCSSTPS NSSKPNGEAI NVSTPNSALH
60 70 80 90 100
LSNQYGFPLN YNGQIQLIFG NMFAGKTSEL LRRLRRYQYA QKETVLVKYI
110 120 130 140 150
NDDRYSKENV STHDLVQQKA IPTDRLEKIA SQLLGYHVIG IDEGQFFPDL
160 170 180 190 200
VEFCEAAANG GKIVIVSALD GTFQRKQFGN VLSLVPMAES VVKLKAVCMV
210 220 230 240 250
CGKDAAFSKR ITDEQQTEVI GGSDKYIATC RKCYMTRNTP YSKKSKSVFQ
260 270
DSMLEEHEEC SDYSEHCEIF SPQKH
Length:275
Mass (Da):30,534
Last modified:March 2, 2010 - v1
Checksum:i2DD74D7E91CEF287
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG738923 Genomic DNA. Translation: EFC36973.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG738923 Genomic DNA. Translation: EFC36973.1.

3D structure databases

ProteinModelPortaliD2W1T6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

InParanoidiD2W1T6.
OMAiDNDIATH.

Family and domain databases

InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NEG-MImported.

Entry informationi

Entry nameiD2W1T6_NAEGR
AccessioniPrimary (citable) accession number: D2W1T6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: January 7, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.