D2VA17 (D2VA17_NAEGR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Malate dehydrogenase RuleBase RU003405
EC=1.1.1.37 RuleBase RU003405

Gene names

ORF Names:

NAEGRDRAFT_83065 EMBL EFC46229.1

Organism

Naegleria gruberi (Amoeba) [Complete proteome]

Taxonomic identifier

5762 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Heterolobosea › Schizopyrenida › Vahlkampfiidae › Naegleria

Protein attributes

Sequence length	329 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-malate + NAD+ = oxaloacetate + NADH.
Sequence similarities	Belongs to the LDH/MDH superfamily. MDH type 2 family. RuleBase RU000421

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle RuleBase RU003405
Ligand	NAD RuleBase RU003405
Molecular function	Oxidoreductase RuleBase RU003405
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro malate metabolic process Inferred from electronic annotation. Source: InterPro tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	L-malate dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	D2VA17 [UniParc]. Last modified March 2, 2010. Version 1. Checksum: 0E651F7308F81EDF	FASTA	329	35,632
	10 20 30 40 50 60 MTKPTMKVLV TGAAGQICYS LIGMIASGQM LGFDQPIILH LLEVPVAMDA LKGVCMEITD 70 80 90 100 110 120 SAYPLVKKVV ATSDYQEAFT DIDVCIMVGA MPRKDGMERK DLLEKNASIF KGQGEALEKY 130 140 150 160 170 180 SKKSVKVLVV GNPANTNCLI AKTYAPSIPA ENFSALTRLD HNRAKAQVAD RLGVNVSDVH 190 200 210 220 230 240 NVTIWGNHSS TQYPDVSHGY VTINGEKKSI TEAVNDDAWL KGDFISTVQK RGAAVIAARK 250 260 270 280 290 300 LSSATSAAKA IVDHVHDWVL GTPEGEWVSM AIPSDGSYGI PEGVIYSFPV TCKDGVVTIV 310 320 QGLKIDDFSR NKMEVTDKEL REEKQLALN

References

[1]

"The genome of Naegleria gruberi illuminates early eukaryotic versatility." Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L., Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R., Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H. , Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C. Cell 140:631-642(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NEG-M EMBL EFC46229.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	GG738859 Genomic DNA. Translation: EFC46229.1.
RefSeq	XP_002678973.1. XM_002678927.1.
3D structure databases
ProteinModelPortal	D2VA17.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8859469.
Phylogenomic databases
OMA	NCLIASK.
Family and domain databases
Gene3D	3.40.50.720. 1 hit. 3.90.110.10. 1 hit.
HAMAP	MF_01517. Malate_dehydrog_2.
InterPro	IPR001557. L-lactate/malate_DH. IPR022383. Lactate/malate_DH_C. IPR001236. Lactate/malate_DH_N. IPR015955. Lactate_DH/Glyco_Ohase_4_C. IPR001252. Malate_DH_AS. IPR011274. Malate_DH_NAD-dep_euk. IPR010945. Malate_DH_type2. IPR016040. NAD(P)-bd_dom. [Graphical view]
PANTHER	PTHR23382. PTHR23382. 1 hit.
Pfam	PF02866. Ldh_1_C. 1 hit. PF00056. Ldh_1_N. 1 hit. [Graphical view]
PIRSF	PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAM	SSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
TIGRFAMs	TIGR01759. MalateDH-SF1. 1 hit. TIGR01758. MDH_euk_cyt. 1 hit.
PROSITE	PS00068. MDH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

D2VA17_NAEGR

Accession

Primary (citable) accession number: D2VA17

Entry history

Integrated into UniProtKB/TrEMBL:	March 2, 2010
Last sequence update:	March 2, 2010
Last modified:	April 3, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)