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Protein

UDP-glucose 6-dehydrogenase

Gene

NAEGRDRAFT_61772

Organism
Naegleria gruberi (Amoeba)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei62NADUniRule annotation1
Binding sitei67NADUniRule annotation1
Binding sitei190NADUniRule annotation1
Active sitei297NucleophileUniRule annotation1
Binding sitei367NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi37 – 42NADUniRule annotation6
Nucleotide bindingi114 – 118NADUniRule annotation5
Nucleotide bindingi156 – 157NADUniRule annotation2
Nucleotide bindingi297 – 300NADUniRule annotation4

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandNADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 6-dehydrogenaseUniRule annotation (EC:1.1.1.22UniRule annotation)
Gene namesi
ORF Names:NAEGRDRAFT_61772Imported
OrganismiNaegleria gruberi (Amoeba)Imported
Taxonomic identifieri5762 [NCBI]
Taxonomic lineageiEukaryotaHeteroloboseaSchizopyrenidaVahlkampfiidaeNaegleria
Proteomesi
  • UP000006671 Componenti: Unassembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi5762.XP_002682609.1

Structurei

3D structure databases

ProteinModelPortaliD2UZ10
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini353 – 482UDPG_MGDP_dh_CInterPro annotationAdd BLAST130

Sequence similaritiesi

Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2666 Eukaryota
COG1004 LUCA
InParanoidiD2UZ10
OMAiANVCFIF

Family and domain databases

InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR036291 NAD(P)-bd_dom_sf
IPR017476 UDP-Glc/GDP-Man
IPR014027 UDP-Glc/GDP-Man_DH_C
IPR036220 UDP-Glc/GDP-Man_DH_C_sf
IPR014026 UDP-Glc/GDP-Man_DH_dimer
IPR001732 UDP-Glc/GDP-Man_DH_N
IPR028356 UDPglc_DH_euk
PfamiView protein in Pfam
PF00984 UDPG_MGDP_dh, 1 hit
PF03720 UDPG_MGDP_dh_C, 1 hit
PF03721 UDPG_MGDP_dh_N, 1 hit
PIRSFiPIRSF500133 UDPglc_DH_euk, 1 hit
PIRSF000124 UDPglc_GDPman_dh, 1 hit
SMARTiView protein in SMART
SM00984 UDPG_MGDP_dh_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
SSF52413 SSF52413, 1 hit
TIGRFAMsiTIGR03026 NDP-sugDHase, 1 hit

Sequencei

Sequence statusi: Complete.

D2UZ10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVDDHSSPS DQEKNTTTDQ EEQPQQPLVI KKIACIGAGY VGGPTMSVIA
60 70 80 90 100
TKCHDIQVII YDMNQQRIDA WNSAELPIFE PGLEEIVMER RGKNLHFTTD
110 120 130 140 150
YQQVVDSDVI FLSVNTPTKY YGVGKGRAAD LKYVESCARQ LRDTIKSGRK
160 170 180 190 200
IIVEKSTVPT RTSIAVKRIL ESGESKARFD ILSNPEFLAE GTAISDLQNP
210 220 230 240 250
DRVLIGGEDE ESIRALSSVY ERWVPKERVI TTNLWSSELS KLVANCMLAQ
260 270 280 290 300
RISSMNAISA LCEKTGADIQ QVSFAVGKDT RIGSKFLQAS VGFGGSCFQK
310 320 330 340 350
DILNLVYLAD HYNLPEVAKY FYGIIEINNF QRERFAKKVI HKLFNTVSGK
360 370 380 390 400
KICVLGFAFK KDTSDTRETS SIFVCKSLLE ERAKIHIYDP KVTKKQIMYD
410 420 430 440 450
MKSIMNDCYD GDFSAKMESS RESELVESNI FVSTDPYEAM SDAHAILVLT
460 470 480 490 500
EWDEFKQYDY KRVFEGMKKP AYLFDGRNIL NRKDLETIGF DVYQIGKQES

HMADW
Length:505
Mass (Da):57,186
Last modified:March 2, 2010 - v1
Checksum:iE5457EC785E0774D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG738846 Genomic DNA Translation: EFC49865.1

Genome annotation databases

EnsemblProtistsiEFC49865; EFC49865; NAEGRDRAFT_61772

Similar proteinsi

Entry informationi

Entry nameiD2UZ10_NAEGR
AccessioniPrimary (citable) accession number: D2UZ10
Entry historyiIntegrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: March 28, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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