Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

D2TRT2

- APHA_CITRI

UniProt

D2TRT2 - APHA_CITRI

Protein

Class B acid phosphatase

Gene

aphA

Organism
Citrobacter rodentium (strain ICC168) (Citrobacter freundii biotype 4280)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (02 Mar 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Dephosphorylates several organic phosphate monoesters. Also has a phosphotransferase activity catalyzing the transfer of low-energy phosphate groups from organic phosphate monoesters to free hydroxyl groups of various organic compounds By similarity.By similarity

    Catalytic activityi

    A phosphate monoester + H2O = an alcohol + phosphate.By similarity

    Cofactori

    Binds 1 magnesium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei69 – 691NucleophileBy similarity
    Metal bindingi69 – 691MagnesiumBy similarity
    Active sitei71 – 711Proton donorBy similarity
    Metal bindingi71 – 711Magnesium; via carbonyl oxygenBy similarity
    Binding sitei177 – 1771SubstrateBy similarity
    Metal bindingi192 – 1921MagnesiumBy similarity

    GO - Molecular functioni

    1. acid phosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciCROD637910:GJIG-3659-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Class B acid phosphataseImportedBy similarity (EC:3.1.3.2ImportedBy similarity)
    Short name:
    CBAPBy similarity
    Gene namesi
    Name:aphAImportedBy similarity
    Ordered Locus Names:ROD_36361
    OrganismiCitrobacter rodentium (strain ICC168) (Citrobacter freundii biotype 4280)
    Taxonomic identifieri637910 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCitrobacter
    ProteomesiUP000001889: Chromosome

    Subcellular locationi

    Periplasm By similarity

    GO - Cellular componenti

    1. outer membrane-bounded periplasmic space Source: InterPro

    Keywords - Cellular componenti

    Periplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525ImportedSequence AnalysisAdd
    BLAST
    Chaini26 – 237212Class B acid phosphataseSequence AnalysisPRO_5000566034Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliD2TRT2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni137 – 1382Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the class B bacterial acid phosphatase family.By similarity

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOGENOMiHOG000270623.
    KOiK03788.
    OMAiPEFWEKM.

    Family and domain databases

    Gene3Di3.40.50.1000. 1 hit.
    InterProiIPR005519. Acid_phosphat_B.
    IPR023214. HAD-like_dom.
    IPR010025. HAD-SF_ppase_IIIB_AphA.
    [Graphical view]
    PfamiPF03767. Acid_phosphat_B. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017818. Acid_Ptase_B. 1 hit.
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR01672. AphA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    D2TRT2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKVSLALSA ACLLFTLNYT ASALASSPSP LNPGTNVAKL AEQAPVHWVS    50
    VAQIEKSLTG RPPMAVGFDI DDTVLFSSPG FWRGKKMYSP DSEEYLKNPA 100
    FWEKMNNGWD EFSIPKEVAR QLIALHLRRG DSIFFVTGRS QTSNERVSKT 150
    LADDFLIPAT VMNPVIFAGD KPGQNSKIQW LQAKNIRIFY GDSDNDIAAA 200
    RELGIRGIRI LRASNSTYKP LPQAGAFGEE VIVNSEY 237
    Length:237
    Mass (Da):26,157
    Last modified:March 2, 2010 - v1
    Checksum:i3BF9EA0904C88479
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN543502 Genomic DNA. Translation: CBG90344.1.
    RefSeqiYP_003367081.1. NC_013716.1.

    Genome annotation databases

    EnsemblBacteriaiCBG90344; CBG90344; ROD_36361.
    GeneIDi8711915.
    KEGGicro:ROD_36361.
    PATRICi32030966. VBICitRod33214_3468.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN543502 Genomic DNA. Translation: CBG90344.1 .
    RefSeqi YP_003367081.1. NC_013716.1.

    3D structure databases

    ProteinModelPortali D2TRT2.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CBG90344 ; CBG90344 ; ROD_36361 .
    GeneIDi 8711915.
    KEGGi cro:ROD_36361.
    PATRICi 32030966. VBICitRod33214_3468.

    Phylogenomic databases

    HOGENOMi HOG000270623.
    KOi K03788.
    OMAi PEFWEKM.

    Enzyme and pathway databases

    BioCyci CROD637910:GJIG-3659-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1000. 1 hit.
    InterProi IPR005519. Acid_phosphat_B.
    IPR023214. HAD-like_dom.
    IPR010025. HAD-SF_ppase_IIIB_AphA.
    [Graphical view ]
    Pfami PF03767. Acid_phosphat_B. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017818. Acid_Ptase_B. 1 hit.
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR01672. AphA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The Citrobacter rodentium genome sequence reveals convergent evolution with human pathogenic Escherichia coli."
      Petty N.K., Bulgin R., Crepin V.F., Cerdeno-Tarraga A.M., Schroeder G.N., Quail M.A., Lennard N., Corton C., Barron A., Clark L., Toribio A.L., Parkhill J., Dougan G., Frankel G., Thomson N.R.
      J. Bacteriol. 192:525-538(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ICC1681 Publication.

    Entry informationi

    Entry nameiAPHA_CITRI
    AccessioniPrimary (citable) accession number: D2TRT2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 25, 2012
    Last sequence update: March 2, 2010
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3