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D2TJ01 (D2TJ01_CITRI) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoheptose isomerase HAMAP-Rule MF_00067
EC=5.3.1.28 HAMAP-Rule MF_00067
Alternative name(s):
Sedoheptulose 7-phosphate isomerase HAMAP-Rule MF_00067
Gene names
Name:gmhA HAMAP-Rule MF_00067 EMBL CBG87003.1
Ordered Locus Names:ROD_02231 EMBL CBG87003.1
OrganismCitrobacter rodentium (strain ICC168) (Citrobacter freundii biotype 4280) [Complete proteome] [HAMAP] EMBL CBG87003.1
Taxonomic identifier637910 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Citrobacter ›

Protein attributes

Sequence length192 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate By similarity. SAAS SAAS004515 HAMAP-Rule MF_00067

Catalytic activity

D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate. SAAS SAAS004515 HAMAP-Rule MF_00067

Cofactor

Binds 1 zinc ion per subunit By similarity. SAAS SAAS004515 HAMAP-Rule MF_00067

Pathway

Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1. SAAS SAAS004515 HAMAP-Rule MF_00067

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00067

Subcellular location

Cytoplasm By similarity SAAS SAAS004515 HAMAP-Rule MF_00067.

Miscellaneous

The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate By similarity. HAMAP-Rule MF_00067

Sequence similarities

Belongs to the SIS family. GmhA subfamily. HAMAP-Rule MF_00067

Contains 1 SIS domain. SAAS SAAS004515 HAMAP-Rule MF_00067

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain37 – 192156SIS By similarity HAMAP-Rule MF_00067
Region52 – 543Substrate binding By similarity HAMAP-Rule MF_00067
Region93 – 942Substrate binding By similarity HAMAP-Rule MF_00067
Region119 – 1213Substrate binding By similarity HAMAP-Rule MF_00067

Sites

Metal binding611Zinc By similarity HAMAP-Rule MF_00067
Metal binding651Zinc By similarity HAMAP-Rule MF_00067
Metal binding1721Zinc By similarity HAMAP-Rule MF_00067
Metal binding1801Zinc By similarity HAMAP-Rule MF_00067
Binding site651Substrate By similarity HAMAP-Rule MF_00067
Binding site1241Substrate By similarity HAMAP-Rule MF_00067
Binding site1721Substrate By similarity HAMAP-Rule MF_00067

Sequences

Sequence LengthMass (Da)Tools
D2TJ01 [UniParc].

Last modified March 2, 2010. Version 1.
Checksum: 8532A24F987D8814

FASTA19220,852
        10         20         30         40         50         60 
MYQDLIRNEL NEAAETLANF LKDDANIHAI QRAAVLLADS FKAGGKVLSC GNGGSHCDAM 

        70         80         90        100        110        120 
HFAEELTGRY RENRPGYPAI AISDVSHLSC VSNDFGYDYV FSRYVEAVGR EGDVLLGIST 

       130        140        150        160        170        180 
SGNSGNVIKA IAAAREKGMK VIALTGKDGG KMAGTADIEI RVPHFGYADR IQEIHIKVIH 

       190 
ILIQLIEKEM VK

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References

[1]"The Citrobacter rodentium genome sequence reveals convergent evolution with human pathogenic Escherichia coli."
Petty N.K., Bulgin R., Crepin V.F., Cerdeno-Tarraga A.M., Schroeder G.N., Quail M.A., Lennard N., Corton C., Barron A., Clark L., Toribio A.L., Parkhill J., Dougan G., Frankel G., Thomson N.R.
J. Bacteriol. 192:525-538(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ICC168 EMBL CBG87003.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FN543502 Genomic DNA. Translation: CBG87003.1.
RefSeqYP_003363867.1. NC_013716.1.

3D structure databases

ProteinModelPortalD2TJ01.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBG87003; CBG87003; ROD_02231.
GeneID8713306.
KEGGcro:ROD_02231.
PATRIC32024356. VBICitRod33214_0226.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000237571.
KOK03271.
OMAFLAHKEA.

Enzyme and pathway databases

BioCycCROD637910:GJIG-236-MONOMER.
UniPathwayUPA00041; UER00436.

Family and domain databases

HAMAPMF_00067. GmhA.
InterProIPR004515. Phosphoheptose_Isoase.
IPR001347. SIS.
[Graphical view]
PfamPF13580. SIS_2. 1 hit.
[Graphical view]
TIGRFAMsTIGR00441. gmhA. 1 hit.
PROSITEPS51464. SIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD2TJ01_CITRI
AccessionPrimary (citable) accession number: D2TJ01
Entry history
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: May 1, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info