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Protein

Superoxide dismutase [Cu-Zn]

Gene

sodC

Organism
Citrobacter rodentium (strain ICC168) (Citrobacter freundii biotype 4280)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Cu cationUniRule annotationNote: Binds 1 copper ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

CopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciCROD637910:GJIG-1440-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:sodCImported
Ordered Locus Names:ROD_14221Imported
OrganismiCitrobacter rodentium (strain ICC168) (Citrobacter freundii biotype 4280)Imported
Taxonomic identifieri637910 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCitrobacter
ProteomesiUP000001889: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 PotentialImportedAdd
BLAST
Chaini20 – 173154 PotentialImportedPRO_5000565473Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliD2THJ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Keywords - Domaini

SignalImported

Phylogenomic databases

HOGENOMiHOG000263449.
KOiK04565.
OMAiGARYACG.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D2THJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRLSLAVLT LLACTGAQAA SEKVEMNLVT AQGIGQSIGE VTINETEKGL
60 70 80 90 100
EFTPDLKALP PGEHGFHLHA NGSCEPAMKD GKASAAEAAG GHYDPHKTGK
110 120 130 140 150
HAGPDGDGHL GDLPVLVVNN EGKAVTPVTA SRLKSLDEIK DKALMIHVGG
160 170
DNMSDQPKPL GGGGARFACG VIK
Length:173
Mass (Da):17,778
Last modified:March 2, 2010 - v1
Checksum:i9A5AFE2F21AB2700
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN543502 Genomic DNA. Translation: CBG88185.1.
RefSeqiYP_003365005.1. NC_013716.1.

Genome annotation databases

EnsemblBacteriaiCBG88185; CBG88185; ROD_14221.
GeneIDi8710785.
KEGGicro:ROD_14221.
PATRICi32026731. VBICitRod33214_1391.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN543502 Genomic DNA. Translation: CBG88185.1.
RefSeqiYP_003365005.1. NC_013716.1.

3D structure databases

ProteinModelPortaliD2THJ1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBG88185; CBG88185; ROD_14221.
GeneIDi8710785.
KEGGicro:ROD_14221.
PATRICi32026731. VBICitRod33214_1391.

Phylogenomic databases

HOGENOMiHOG000263449.
KOiK04565.
OMAiGARYACG.

Enzyme and pathway databases

BioCyciCROD637910:GJIG-1440-MONOMER.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The Citrobacter rodentium genome sequence reveals convergent evolution with human pathogenic Escherichia coli."
    Petty N.K., Bulgin R., Crepin V.F., Cerdeno-Tarraga A.M., Schroeder G.N., Quail M.A., Lennard N., Corton C., Barron A., Clark L., Toribio A.L., Parkhill J., Dougan G., Frankel G., Thomson N.R.
    J. Bacteriol. 192:525-538(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ICC168Imported.

Entry informationi

Entry nameiD2THJ1_CITRI
AccessioniPrimary (citable) accession number: D2THJ1
Entry historyi
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: March 4, 2015
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.