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Protein

Isocitrate dehydrogenase [NADP]

Gene

icdA

Organism
Erwinia pyrifoliae (strain DSM 12163 / CIP 106111 / Ep16/96)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciEPYR644651:GLCX-2300-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdAImported
Ordered Locus Names:EPYR_02245Imported
OrganismiErwinia pyrifoliae (strain DSM 12163 / CIP 106111 / Ep16/96)Imported
Taxonomic identifieri644651 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeErwinia
ProteomesiUP000008690 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliD2TCH2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D2TCH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRILQVINK KKRSKERLME SKVVVPVEGQ KITLDQGKLN VPDNPIIPFI
60 70 80 90 100
EGDGIGVDVS PVMIKVVDAA VQKAYSGERK ISWMEIYTGE KSVELYGQDV
110 120 130 140 150
WLPEETLDLI KEYRVAIKGP LTTPVGGGIR SLNVALRQQL DLYICLRPVR
160 170 180 190 200
YYTGTPSPVK RPEDTDMVIF RENSEDIYAG IEWKAGTPEA DKVIKFLREE
210 220 230 240 250
MGVKKIRFPE QCGIGVKPCS QAGTQRLVRA AIEYAIANDR DSVTLVHKGN
260 270 280 290 300
IMKFTEGAFK DWGYQLAKDE FGGEPIDGGP WLTINNPNTG KEIVIKDVIA
310 320 330 340 350
DAFLQQILLR PAEYDVIACM NLNGDYISDA LAAQVGGIGI APGANIGDEC
360 370 380 390 400
ALFEATHGTA PKYAGQDKVN PGSVILSAEM MLRHMGWTEA ADLIVKGMEG
410 420 430
AIAAKTVTYD FERQMDGAKL LKSSEFGDAM IKHM
Length:434
Mass (Da):47,785
Last modified:March 2, 2010 - v1
Checksum:i136C24F0F73E9441
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN392235 Genomic DNA. Translation: CAY74625.1.
RefSeqiWP_014539041.1. NC_017390.1.
YP_005802996.1. NC_017390.1.

Genome annotation databases

EnsemblBacteriaiCAY74625; CAY74625; EPYR_02245.
KEGGiepr:EPYR_02245.
PATRICi36678018. VBIErwPyr40668_2055.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN392235 Genomic DNA. Translation: CAY74625.1.
RefSeqiWP_014539041.1. NC_017390.1.
YP_005802996.1. NC_017390.1.

3D structure databases

ProteinModelPortaliD2TCH2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAY74625; CAY74625; EPYR_02245.
KEGGiepr:EPYR_02245.
PATRICi36678018. VBIErwPyr40668_2055.

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.

Enzyme and pathway databases

BioCyciEPYR644651:GLCX-2300-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the fire blight pathogen Erwinia pyrifoliae DSM 12163T and comparative genomic insights into plant pathogenicity."
    Smits T.H., Jaenicke S., Rezzonico F., Kamber T., Goesmann A., Frey J.E., Duffy B.
    BMC Genomics 11:2-2(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 12163 / CIP 106111 / Ep16/96Imported.

Entry informationi

Entry nameiD2TCH2_ERWP6
AccessioniPrimary (citable) accession number: D2TCH2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: May 27, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.