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D2TCH2

- D2TCH2_ERWP6

UniProt

D2TCH2 - D2TCH2_ERWP6

Protein

Isocitrate dehydrogenase [NADP]

Gene

icdA

Organism
Erwinia pyrifoliae (strain DSM 12163 / CIP 106111 / Ep16/96)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (02 Mar 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciEPYR644651:GLCX-2300-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:icdAImported
    Ordered Locus Names:EPYR_02245Imported
    OrganismiErwinia pyrifoliae (strain DSM 12163 / CIP 106111 / Ep16/96)Imported
    Taxonomic identifieri644651 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeErwinia
    ProteomesiUP000008690: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliD2TCH2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000021113.
    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D2TCH2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTRILQVINK KKRSKERLME SKVVVPVEGQ KITLDQGKLN VPDNPIIPFI    50
    EGDGIGVDVS PVMIKVVDAA VQKAYSGERK ISWMEIYTGE KSVELYGQDV 100
    WLPEETLDLI KEYRVAIKGP LTTPVGGGIR SLNVALRQQL DLYICLRPVR 150
    YYTGTPSPVK RPEDTDMVIF RENSEDIYAG IEWKAGTPEA DKVIKFLREE 200
    MGVKKIRFPE QCGIGVKPCS QAGTQRLVRA AIEYAIANDR DSVTLVHKGN 250
    IMKFTEGAFK DWGYQLAKDE FGGEPIDGGP WLTINNPNTG KEIVIKDVIA 300
    DAFLQQILLR PAEYDVIACM NLNGDYISDA LAAQVGGIGI APGANIGDEC 350
    ALFEATHGTA PKYAGQDKVN PGSVILSAEM MLRHMGWTEA ADLIVKGMEG 400
    AIAAKTVTYD FERQMDGAKL LKSSEFGDAM IKHM 434
    Length:434
    Mass (Da):47,785
    Last modified:March 2, 2010 - v1
    Checksum:i136C24F0F73E9441
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN392235 Genomic DNA. Translation: CAY74625.1.
    RefSeqiYP_005802996.1. NC_017390.1.

    Genome annotation databases

    EnsemblBacteriaiCAY74625; CAY74625; EPYR_02245.
    GeneIDi12937550.
    KEGGiepr:EPYR_02245.
    PATRICi36678018. VBIErwPyr40668_2055.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN392235 Genomic DNA. Translation: CAY74625.1 .
    RefSeqi YP_005802996.1. NC_017390.1.

    3D structure databases

    ProteinModelPortali D2TCH2.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAY74625 ; CAY74625 ; EPYR_02245 .
    GeneIDi 12937550.
    KEGGi epr:EPYR_02245.
    PATRICi 36678018. VBIErwPyr40668_2055.

    Phylogenomic databases

    HOGENOMi HOG000021113.
    KOi K00031.

    Enzyme and pathway databases

    BioCyci EPYR644651:GLCX-2300-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the fire blight pathogen Erwinia pyrifoliae DSM 12163T and comparative genomic insights into plant pathogenicity."
      Smits T.H., Jaenicke S., Rezzonico F., Kamber T., Goesmann A., Frey J.E., Duffy B.
      BMC Genomics 11:2-2(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 12163 / CIP 106111 / Ep16/96Imported.

    Entry informationi

    Entry nameiD2TCH2_ERWP6
    AccessioniPrimary (citable) accession number: D2TCH2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 2, 2010
    Last sequence update: March 2, 2010
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3