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D2TCH2 (D2TCH2_ERWP6) Unreviewed, UniProtKB/TrEMBL

Last modified October 16, 2013. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] RuleBase RU004446

EC=1.1.1.42 RuleBase RU004446
Gene names
Name:icdA EMBL CAY74625.1
Ordered Locus Names:EPYR_02245 EMBL CAY74625.1
OrganismErwinia pyrifoliae (strain DSM 12163 / CIP 106111 / Ep16/96) [Complete proteome] [HAMAP] EMBL CAY74625.1
Taxonomic identifier644651 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeErwinia

Protein attributes

Sequence length434 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. RuleBase RU004446

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. RuleBase RU004446

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443

Sequences

Sequence LengthMass (Da)Tools
D2TCH2 [UniParc].

Last modified March 2, 2010. Version 1.
Checksum: 136C24F0F73E9441

FASTA43447,785
        10         20         30         40         50         60 
MTRILQVINK KKRSKERLME SKVVVPVEGQ KITLDQGKLN VPDNPIIPFI EGDGIGVDVS 

        70         80         90        100        110        120 
PVMIKVVDAA VQKAYSGERK ISWMEIYTGE KSVELYGQDV WLPEETLDLI KEYRVAIKGP 

       130        140        150        160        170        180 
LTTPVGGGIR SLNVALRQQL DLYICLRPVR YYTGTPSPVK RPEDTDMVIF RENSEDIYAG 

       190        200        210        220        230        240 
IEWKAGTPEA DKVIKFLREE MGVKKIRFPE QCGIGVKPCS QAGTQRLVRA AIEYAIANDR 

       250        260        270        280        290        300 
DSVTLVHKGN IMKFTEGAFK DWGYQLAKDE FGGEPIDGGP WLTINNPNTG KEIVIKDVIA 

       310        320        330        340        350        360 
DAFLQQILLR PAEYDVIACM NLNGDYISDA LAAQVGGIGI APGANIGDEC ALFEATHGTA 

       370        380        390        400        410        420 
PKYAGQDKVN PGSVILSAEM MLRHMGWTEA ADLIVKGMEG AIAAKTVTYD FERQMDGAKL 

       430 
LKSSEFGDAM IKHM 

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References

[1]"Complete genome sequence of the fire blight pathogen Erwinia pyrifoliae DSM 12163T and comparative genomic insights into plant pathogenicity."
Smits T.H., Jaenicke S., Rezzonico F., Kamber T., Goesmann A., Frey J.E., Duffy B.
BMC Genomics 11:2-2(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 12163 / CIP 106111 / Ep16/96.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FN392235 Genomic DNA. Translation: CAY74625.1.
RefSeqYP_005802996.1. NC_017390.1.

3D structure databases

ProteinModelPortalD2TCH2.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAY74625; CAY74625; EPYR_02245.
GeneID12937550.
KEGGepr:EPYR_02245.
PATRIC36678018. VBIErwPyr40668_2055.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000021113.
KOK00031.

Enzyme and pathway databases

BioCycEPYR644651:GLCX-2300-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11835. PTHR11835. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR00183. prok_nadp_idh. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD2TCH2_ERWP6
AccessionPrimary (citable) accession number: D2TCH2
Entry history
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: October 16, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)