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D2TAH4

- D2TAH4_ERWP6

UniProt

D2TAH4 - D2TAH4_ERWP6

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Protein
Thymidine kinase
Gene
tdk, EPYR_01773
Organism
Erwinia pyrifoliae (strain DSM 12163 / CIP 106111 / Ep16/96)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881Proton acceptor By similarityUniRule annotation
Metal bindingi145 – 1451Zinc By similarityUniRule annotation
Metal bindingi147 – 1471Zinc By similarityUniRule annotation
Metal bindingi182 – 1821Zinc By similarityUniRule annotation
Metal bindingi185 – 1851Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATP By similarityUniRule annotation
Nucleotide bindingi87 – 904ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciEPYR644651:GLCX-1828-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:EPYR_01773Imported
OrganismiErwinia pyrifoliae (strain DSM 12163 / CIP 106111 / Ep16/96)Imported
Taxonomic identifieri644651 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeErwinia
ProteomesiUP000008690: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliD2TAH4.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076391.
KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D2TAH4-1 [UniParc]FASTAAdd to Basket

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MAQLYFYYSA MNAGKSTALL QSSYNYHERG MRTLVYTAEI DNRFGAARVS    50
SRIGLSSPAK LYNNSTSLFV EISAEHQRQA VHCVLVDESQ FLTREQVKSL 100
SEVVDMLDIP VLCYGLRTDF RGELFTGSQY LLAWSDKLIE LKTICHCGRK 150
ASMVLRIDAG GKPFKEGEQV QIGGNERYVS VCRKHYTEAL ESGSLQAIYG 200
KQQPG 205
Length:205
Mass (Da):22,999
Last modified:March 2, 2010 - v1
Checksum:i67641328E7F2C237
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN392235 Genomic DNA. Translation: CAY74153.1.
RefSeqiYP_005802524.1. NC_017390.1.

Genome annotation databases

EnsemblBacteriaiCAY74153; CAY74153; EPYR_01773.
GeneIDi12935928.
KEGGiepr:EPYR_01773.
PATRICi36677186. VBIErwPyr40668_1641.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN392235 Genomic DNA. Translation: CAY74153.1 .
RefSeqi YP_005802524.1. NC_017390.1.

3D structure databases

ProteinModelPortali D2TAH4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAY74153 ; CAY74153 ; EPYR_01773 .
GeneIDi 12935928.
KEGGi epr:EPYR_01773.
PATRICi 36677186. VBIErwPyr40668_1641.

Phylogenomic databases

HOGENOMi HOG000076391.
KOi K00857.

Enzyme and pathway databases

BioCyci EPYR644651:GLCX-1828-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the fire blight pathogen Erwinia pyrifoliae DSM 12163T and comparative genomic insights into plant pathogenicity."
    Smits T.H., Jaenicke S., Rezzonico F., Kamber T., Goesmann A., Frey J.E., Duffy B.
    BMC Genomics 11:2-2(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 12163 / CIP 106111 / Ep16/96.

Entry informationi

Entry nameiD2TAH4_ERWP6
AccessioniPrimary (citable) accession number: D2TAH4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: June 11, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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