Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

D2SEH3 (D2SEH3_GEOOG) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Gobs_4044 EMBL ADB76609.1
OrganismGeodermatophilus obscurus (strain ATCC 25078 / DSM 43160 / JCM 3152 / G-20) [Complete proteome] [HAMAP] EMBL ADB76609.1
Taxonomic identifier526225 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeGeodermatophilaceaeGeodermatophilus

Protein attributes

Sequence length384 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain151 – 366216ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding186 – 24156ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3161Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3331Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3331Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3351Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
D2SEH3 [UniParc].

Last modified March 2, 2010. Version 1.
Checksum: 47FE5DD835A17D17

FASTA38439,794
        10         20         30         40         50         60 
MSGQAGKLRI AVVFGGRSAE HSISCVSAGA VLAGLDPDRY DVVPVGIARD GRWVLAEPAQ 

        70         80         90        100        110        120 
RLAIADGELP EVTGGTAVSL VGDPGGRGLA VLEPAAGVAS ALTEVDVVFP VLHGAYGEDG 

       130        140        150        160        170        180 
TIQGLLEMSG IPYVGSGVFA SAASMDKEFT KKLLAAAGLP QGVHVVLRDA SGAVSADPGV 

       190        200        210        220        230        240 
LDDADRERLG LPVFVKPCRA GSSIGITKVT DWAQFPEAVA TAASVDPKVI VEAAVPGREV 

       250        260        270        280        290        300 
ECGVLARPDG PPQASLPAEI RLRPGTEWYD FAAKYLDDAV DFDVPADLTP EQTRLVQETA 

       310        320        330        340        350        360 
RKAFLALDCR GLARVDFFLG TGPDGADRLV VNEVNTMPGF TPISMYPRMW AATGVDFAAL 

       370        380 
VDRLVEVALA ARPAAEATLD GTRA 

« Hide

References

[1]"The complete genome of Geodermatophilus obscurus DSM 43160."
US DOE Joint Genome Institute (JGI-PGF)
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N., Munk A.C., Brettin T., Detter J.C., Han C., Larimer F., Land M. expand/collapse author list , Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Jando M., Schneider S., Klenk H.-P., Eisen J.A.
Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25078 / DSM 43160 / JCM 3152 / G-20.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001867 Genomic DNA. Translation: ADB76609.1.
RefSeqYP_003410980.1. NC_013757.1.

3D structure databases

ProteinModelPortalD2SEH3.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADB76609; ADB76609; Gobs_4044.
GeneID8755732.
KEGGgob:Gobs_4044.
PATRIC32177235. VBIGeoObs49253_4016.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011593.
KOK01921.
OMAMDKIAMK.

Enzyme and pathway databases

BioCycGOBS526225:GI00-4090-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD2SEH3_GEOOG
AccessionPrimary (citable) accession number: D2SEH3
Entry history
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: February 19, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)