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D2S6E2

- PSB_GEOOG

UniProt

D2S6E2 - PSB_GEOOG

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Protein
Proteasome subunit beta
Gene
prcB, Gobs_2682
Organism
Geodermatophilus obscurus (strain ATCC 25078 / DSM 43160 / JCM 3152 / G-20)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation By similarity.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

Enzyme regulationi

The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei54 – 541Nucleophile By similarity

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. modification-dependent protein catabolic process Source: UniProtKB-HAMAP
  2. proteasomal protein catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

BioCyciGOBS526225:GI00-2711-MONOMER.
UniPathwayiUPA00997.

Protein family/group databases

MEROPSiT01.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta (EC:3.4.25.1)
Alternative name(s):
20S proteasome beta subunit
Proteasome core protein PrcB
Gene namesi
Name:prcB
Ordered Locus Names:Gobs_2682
OrganismiGeodermatophilus obscurus (strain ATCC 25078 / DSM 43160 / JCM 3152 / G-20)
Taxonomic identifieri526225 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeGeodermatophilaceaeGeodermatophilus
ProteomesiUP000001382: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. proteasome core complex, beta-subunit complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 5353Removed in mature form; by autocatalysis By similarity
PRO_0000397510Add
BLAST
Chaini54 – 280227Proteasome subunit betaUniRule annotation
PRO_0000397511Add
BLAST

Keywords - PTMi

Autocatalytic cleavage, Zymogen

Interactioni

Subunit structurei

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC By similarity.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.

Phylogenomic databases

HOGENOMiHOG000245308.
KOiK03433.
OMAiFQVELEH.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_02113_B. Proteasome_B_B.
InterProiIPR029055. Ntn_hydrolases_N.
IPR022483. Pept_T1A_Psome_suB_actinobac.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR03690. 20S_bact_beta. 1 hit.
PROSITEiPS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D2S6E2-1 [UniParc]FASTAAdd to Basket

« Hide

MSEYSAGRSG FSPAYLDRVG SSFTDFLAAA APHLLPGSRP VPQIPVGNVT    50
PHGTTIVSVT YDGGVLMGGD RRATMGNLIS SREIEKVYPA DAWSVIGIAG 100
AAGIAIEMVR LYQVELEHYE KIEGLTLSLD GKANRLAQMI RGNLGAALQG 150
LAVVPLFAGF DLDAAPGAAP GRIFSYDVTG GNYEERGYSA VGSGSLFARN 200
SLKKTWRPNL DGDAATRSLV EALYDAADDD SATGGPDPVR RLYPIVYRVD 250
AEGAVRVPDD EIAAVATRIT DERSAADGQG 280
Length:280
Mass (Da):29,436
Last modified:March 2, 2010 - v1
Checksum:iD3F1DEB8112F9BE3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001867 Genomic DNA. Translation: ADB75316.1.
RefSeqiYP_003409687.1. NC_013757.1.

Genome annotation databases

EnsemblBacteriaiADB75316; ADB75316; Gobs_2682.
GeneIDi8754354.
KEGGigob:Gobs_2682.
PATRICi32174490. VBIGeoObs49253_2658.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001867 Genomic DNA. Translation: ADB75316.1 .
RefSeqi YP_003409687.1. NC_013757.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi T01.005.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADB75316 ; ADB75316 ; Gobs_2682 .
GeneIDi 8754354.
KEGGi gob:Gobs_2682.
PATRICi 32174490. VBIGeoObs49253_2658.

Phylogenomic databases

HOGENOMi HOG000245308.
KOi K03433.
OMAi FQVELEH.

Enzyme and pathway databases

UniPathwayi UPA00997 .
BioCyci GOBS526225:GI00-2711-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_02113_B. Proteasome_B_B.
InterProi IPR029055. Ntn_hydrolases_N.
IPR022483. Pept_T1A_Psome_suB_actinobac.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR03690. 20S_bact_beta. 1 hit.
PROSITEi PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25078 / DSM 43160 / JCM 3152 / G-20.

Entry informationi

Entry nameiPSB_GEOOG
AccessioniPrimary (citable) accession number: D2S6E2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: March 2, 2010
Last modified: June 11, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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