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Protein

Mycothiol acetyltransferase

Gene

mshD

Organism
Geodermatophilus obscurus (strain ATCC 25078 / DSM 43160 / JCM 3152 / G-20)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.UniRule annotation

Catalytic activityi

Desacetylmycothiol + acetyl-CoA = CoA + mycothiol.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391Desacetylmycothiol; via amide nitrogenUniRule annotation
Binding sitei187 – 1871DesacetylmycothiolUniRule annotation
Binding sitei226 – 2261DesacetylmycothiolUniRule annotation
Binding sitei240 – 2401DesacetylmycothiolUniRule annotation
Binding sitei278 – 2781Desacetylmycothiol; via carbonyl oxygenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciGOBS526225:GI00-4703-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mycothiol acetyltransferaseUniRule annotation (EC:2.3.1.189UniRule annotation)
Short name:
MSH acetyltransferaseUniRule annotation
Alternative name(s):
Mycothiol synthaseUniRule annotation
Gene namesi
Name:mshDUniRule annotation
Ordered Locus Names:Gobs_4647
OrganismiGeodermatophilus obscurus (strain ATCC 25078 / DSM 43160 / JCM 3152 / G-20)
Taxonomic identifieri526225 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaGeodermatophilalesGeodermatophilaceaeGeodermatophilus
Proteomesi
  • UP000001382 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Mycothiol acetyltransferasePRO_0000400258Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi526225.Gobs_4647.

Structurei

3D structure databases

ProteinModelPortaliD2S4P5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 155148N-acetyltransferase 1UniRule annotationAdd
BLAST
Domaini160 – 308149N-acetyltransferase 2UniRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni84 – 863Acetyl-CoA binding 1UniRule annotation
Regioni244 – 2463Acetyl-CoA binding 2UniRule annotation
Regioni251 – 2577Acetyl-CoA binding 2UniRule annotation

Sequence similaritiesi

Belongs to the acetyltransferase family. MshD subfamily.UniRule annotation
Contains 2 N-acetyltransferase domains.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108RTV. Bacteria.
COG0456. LUCA.
HOGENOMiHOG000248937.
KOiK15520.
OMAiMLYVDES.
OrthoDBiPOG091H09IL.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
HAMAPiMF_01698. MshD. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR017813. Mycothiol_AcTrfase.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 2 hits.
[Graphical view]
PIRSFiPIRSF021524. MSH_acetyltransferase. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR03448. mycothiol_MshD. 1 hit.
PROSITEiPS51186. GNAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D2S4P5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAPLVRDV DRLDPAGVAA VLALLRAATA ADGVRPLSEE AELRLQHGGP
60 70 80 90 100
AGGRDVLATA ADGALTGYAR FEGGEGTGDA EAELVVAPGS RRRGVGRALL
110 120 130 140 150
TRLEELAGDR PLRVWAHGDL PGSAELAQRH GYERARVLLQ MRRELAGVDP
160 170 180 190 200
EPRLRLPEGV QVRTFRSGTD EQAWLRTNAR AFASHPEQGS WTAEDLRLRE
210 220 230 240 250
AEPWFDPAGF FLAWDGDRLL GSHWTKVHPP GDEGPEAVGE VYVLGIDPDA
260 270 280 290 300
QGLGLGRALT DVGLAHLRRL GLRQVLLYVE EDNTAAVTLY ERSGFTRHAV

DVSWRRAR
Length:308
Mass (Da):33,398
Last modified:March 2, 2010 - v1
Checksum:i8D117115974356A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001867 Genomic DNA. Translation: ADB77195.1.
RefSeqiWP_012950619.1. NC_013757.1.

Genome annotation databases

EnsemblBacteriaiADB77195; ADB77195; Gobs_4647.
KEGGigob:Gobs_4647.
PATRICi32178501. VBIGeoObs49253_4640.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001867 Genomic DNA. Translation: ADB77195.1.
RefSeqiWP_012950619.1. NC_013757.1.

3D structure databases

ProteinModelPortaliD2S4P5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi526225.Gobs_4647.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADB77195; ADB77195; Gobs_4647.
KEGGigob:Gobs_4647.
PATRICi32178501. VBIGeoObs49253_4640.

Phylogenomic databases

eggNOGiENOG4108RTV. Bacteria.
COG0456. LUCA.
HOGENOMiHOG000248937.
KOiK15520.
OMAiMLYVDES.
OrthoDBiPOG091H09IL.

Enzyme and pathway databases

BioCyciGOBS526225:GI00-4703-MONOMER.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
HAMAPiMF_01698. MshD. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR017813. Mycothiol_AcTrfase.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 2 hits.
[Graphical view]
PIRSFiPIRSF021524. MSH_acetyltransferase. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR03448. mycothiol_MshD. 1 hit.
PROSITEiPS51186. GNAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSHD_GEOOG
AccessioniPrimary (citable) accession number: D2S4P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: March 2, 2010
Last modified: September 7, 2016
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.