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Protein

ADP-dependent (S)-NAD(P)H-hydrate dehydratase

Gene

nnrD

Organism
Haloterrigena turkmenica (strain ATCC 51198 / DSM 5511 / NCIMB 13204 / VKM B-1734) (Halococcus turkmenicus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.UniRule annotation

Catalytic activityi

ADP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine-dinucleotide = AMP + phosphate + NADH.UniRule annotation
ADP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine-dinucleotide phosphate = AMP + phosphate + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei101 – 1011NAD(P)HX; via amide nitrogenUniRule annotation
Binding sitei201 – 2011NAD(P)HXUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi191 – 20010ADPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciHTUR543526:GH7B-2862-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-dependent (S)-NAD(P)H-hydrate dehydrataseUniRule annotation (EC:4.2.1.136UniRule annotation)
Alternative name(s):
ADP-dependent NAD(P)HX dehydrataseUniRule annotation
Gene namesi
Name:nnrDUniRule annotation
Ordered Locus Names:Htur_2808
OrganismiHaloterrigena turkmenica (strain ATCC 51198 / DSM 5511 / NCIMB 13204 / VKM B-1734) (Halococcus turkmenicus)
Taxonomic identifieri543526 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaNatrialbalesNatrialbaceaeHaloterrigena
Proteomesi
  • UP000001903 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257ADP-dependent (S)-NAD(P)H-hydrate dehydratasePRO_0000416153Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi543526.Htur_2808.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 257257YjeF C-terminalUniRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni144 – 1507NAD(P)HXUniRule annotation

Sequence similaritiesi

Belongs to the NnrD/CARKD family.UniRule annotation
Contains 1 YjeF C-terminal domain.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00018. Archaea.
COG0063. LUCA.
HOGENOMiHOG000095375.
OMAiTAEYGPG.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_01965. NADHX_dehydratase.
InterProiIPR000631. CARKD.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF01256. Carb_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00196. yjeF_cterm. 1 hit.
PROSITEiPS51383. YJEF_C_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D2RXF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRLQRTLSN ISEEEIDNGR IGIVAGAIEY PNQPALVGRA ALRTGSDHVR
60 70 80 90 100
ALVADPIYEI VAGQDPNLLV DRYAGEQFEE SAVERTREMS EWADALVIGP
110 120 130 140 150
GLVDADPQAV CEAIDTIDVP MVVDALALEP SLDADLSNAV LTPSGAEVGP
160 170 180 190 200
IRDEYGSLEA FSEETGAVIT LTGDVDEIVA DGERLENETG TSAMTVAGTG
210 220 230 240 250
DTMVGIVASL LGQGMDRREA AELGAWILGK TGELATANHG PGVVATDVIE

RIPDTIR
Length:257
Mass (Da):26,964
Last modified:March 2, 2010 - v1
Checksum:iB699C8B72FA1946C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001860 Genomic DNA. Translation: ADB61680.1.
RefSeqiWP_012943949.1. NC_013743.1.

Genome annotation databases

EnsemblBacteriaiADB61680; ADB61680; Htur_2808.
GeneIDi8743424.
KEGGihtu:Htur_2808.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001860 Genomic DNA. Translation: ADB61680.1.
RefSeqiWP_012943949.1. NC_013743.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi543526.Htur_2808.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADB61680; ADB61680; Htur_2808.
GeneIDi8743424.
KEGGihtu:Htur_2808.

Phylogenomic databases

eggNOGiarCOG00018. Archaea.
COG0063. LUCA.
HOGENOMiHOG000095375.
OMAiTAEYGPG.

Enzyme and pathway databases

BioCyciHTUR543526:GH7B-2862-MONOMER.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_01965. NADHX_dehydratase.
InterProiIPR000631. CARKD.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF01256. Carb_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00196. yjeF_cterm. 1 hit.
PROSITEiPS51383. YJEF_C_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51198 / DSM 5511 / NCIMB 13204 / VKM B-1734.

Entry informationi

Entry nameiNNRD_HALTV
AccessioniPrimary (citable) accession number: D2RXF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: March 2, 2010
Last modified: November 11, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.