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D2RSK7

- D2RSK7_HALTV

UniProt

D2RSK7 - D2RSK7_HALTV

Protein

DNA ligase

Gene

lig

Organism
Haloterrigena turkmenica (strain ATCC 51198 / DSM 5511 / NCIMB 13204 / VKM B-1734) (Halococcus turkmenicus)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (02 Mar 2010)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei275 – 2751ATPUniRule annotation
    Active sitei277 – 2771N6-AMP-lysine intermediateUniRule annotation
    Binding sitei282 – 2821ATPUniRule annotation
    Binding sitei302 – 3021ATPUniRule annotation
    Binding sitei331 – 3311ATPUniRule annotation
    Binding sitei371 – 3711ATPUniRule annotation
    Binding sitei458 – 4581ATPUniRule annotation
    Binding sitei464 – 4641ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHTUR543526:GH7B-1933-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:Htur_1898Imported
    OrganismiHaloterrigena turkmenica (strain ATCC 51198 / DSM 5511 / NCIMB 13204 / VKM B-1734) (Halococcus turkmenicus)Imported
    Taxonomic identifieri543526 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloterrigena
    ProteomesiUP000001903: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000036008.
    KOiK10747.
    OMAiARVQVHK.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D2RSK7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFATFADRA AAIEAEPADL EIVARTSELL ADAGDDSEDR RSAGSAVDPQ    50
    TLEVVARFVQ GRVFPAWDST KLDIGPTTCY EAIARAAGTN VGSDDVEERL 100
    AEVGEIGEVA ASYDFGGQQG LGAFTGGGGG NGAGGAAGND LTVREVYETL 150
    ADLAAAEGSG SQDRKIDLLF GLFNRCSSEE ARYLARLVLS EMRIGVGEGS 200
    VRDAISEAFD VPVEHVERAL QVSNDYGQVA RVARDEGREG LDAMDLEVGR 250
    PVQAMLAQAG TVTDALEEWD EAAVEWKYDG ARVQLHHRIG DDGTTETCVF 300
    SRNMEEVTDA FPEVVEFADE TLEEPAILDG EVVAIDEDDE PLPFQEVLKR 350
    FRRKHDVAKA REDVTVRPVF FDCLHAGGED LLEEPLTTRH ERLRAVLADA 400
    DDSSDATVED ERDIEALSLL WTTDDPDEIE AIDAEALEAG HEGIMLKDPD 450
    SAYSPGRRGK HWRKRKPDVE TLDCVVTGAE WGEGRRATFL GTFELSVRAG 500
    DDLETVGKVA TGITDEKLEE LTALLEPHIA TEEGQAVDIE PAVVFEVGYE 550
    EIQSSPTYSS GYALRFPRFL GVRSDKDPDD ADTLERVERL RA 592
    Length:592
    Mass (Da):64,362
    Last modified:March 2, 2010 - v1
    Checksum:i100475429399F4DB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001860 Genomic DNA. Translation: ADB60783.1.
    RefSeqiWP_012943073.1. NC_013743.1.
    YP_003403456.1. NC_013743.1.

    Genome annotation databases

    EnsemblBacteriaiADB60783; ADB60783; Htur_1898.
    GeneIDi8742496.
    KEGGihtu:Htur_1898.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001860 Genomic DNA. Translation: ADB60783.1 .
    RefSeqi WP_012943073.1. NC_013743.1.
    YP_003403456.1. NC_013743.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADB60783 ; ADB60783 ; Htur_1898 .
    GeneIDi 8742496.
    KEGGi htu:Htur_1898.

    Phylogenomic databases

    HOGENOMi HOG000036008.
    KOi K10747.
    OMAi ARVQVHK.

    Enzyme and pathway databases

    BioCyci HTUR543526:GH7B-1933-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51198 / DSM 5511 / NCIMB 13204 / VKM B-1734Imported.

    Entry informationi

    Entry nameiD2RSK7_HALTV
    AccessioniPrimary (citable) accession number: D2RSK7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 2, 2010
    Last sequence update: March 2, 2010
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3