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Protein

DNA ligase

Gene

lig

Organism
Haloterrigena turkmenica (strain ATCC 51198 / DSM 5511 / NCIMB 13204 / VKM B-1734) (Halococcus turkmenicus)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei275 – 2751ATPUniRule annotation
Active sitei277 – 2771N6-AMP-lysine intermediateUniRule annotation
Binding sitei282 – 2821ATPUniRule annotation
Binding sitei302 – 3021ATPUniRule annotation
Binding sitei331 – 3311ATPUniRule annotation
Binding sitei371 – 3711ATPUniRule annotation
Binding sitei458 – 4581ATPUniRule annotation
Binding sitei464 – 4641ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciHTUR543526:GH7B-1933-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Htur_1898Imported
OrganismiHaloterrigena turkmenica (strain ATCC 51198 / DSM 5511 / NCIMB 13204 / VKM B-1734) (Halococcus turkmenicus)Imported
Taxonomic identifieri543526 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloterrigena
ProteomesiUP000001903 Componenti: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK10747.
OMAiGRPRPFQ.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D2RSK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFATFADRA AAIEAEPADL EIVARTSELL ADAGDDSEDR RSAGSAVDPQ
60 70 80 90 100
TLEVVARFVQ GRVFPAWDST KLDIGPTTCY EAIARAAGTN VGSDDVEERL
110 120 130 140 150
AEVGEIGEVA ASYDFGGQQG LGAFTGGGGG NGAGGAAGND LTVREVYETL
160 170 180 190 200
ADLAAAEGSG SQDRKIDLLF GLFNRCSSEE ARYLARLVLS EMRIGVGEGS
210 220 230 240 250
VRDAISEAFD VPVEHVERAL QVSNDYGQVA RVARDEGREG LDAMDLEVGR
260 270 280 290 300
PVQAMLAQAG TVTDALEEWD EAAVEWKYDG ARVQLHHRIG DDGTTETCVF
310 320 330 340 350
SRNMEEVTDA FPEVVEFADE TLEEPAILDG EVVAIDEDDE PLPFQEVLKR
360 370 380 390 400
FRRKHDVAKA REDVTVRPVF FDCLHAGGED LLEEPLTTRH ERLRAVLADA
410 420 430 440 450
DDSSDATVED ERDIEALSLL WTTDDPDEIE AIDAEALEAG HEGIMLKDPD
460 470 480 490 500
SAYSPGRRGK HWRKRKPDVE TLDCVVTGAE WGEGRRATFL GTFELSVRAG
510 520 530 540 550
DDLETVGKVA TGITDEKLEE LTALLEPHIA TEEGQAVDIE PAVVFEVGYE
560 570 580 590
EIQSSPTYSS GYALRFPRFL GVRSDKDPDD ADTLERVERL RA
Length:592
Mass (Da):64,362
Last modified:March 2, 2010 - v1
Checksum:i100475429399F4DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001860 Genomic DNA. Translation: ADB60783.1.
RefSeqiYP_003403456.1. NC_013743.1.

Genome annotation databases

EnsemblBacteriaiADB60783; ADB60783; Htur_1898.
GeneIDi8742496.
KEGGihtu:Htur_1898.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001860 Genomic DNA. Translation: ADB60783.1.
RefSeqiYP_003403456.1. NC_013743.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADB60783; ADB60783; Htur_1898.
GeneIDi8742496.
KEGGihtu:Htur_1898.

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK10747.
OMAiGRPRPFQ.

Enzyme and pathway databases

BioCyciHTUR543526:GH7B-1933-MONOMER.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51198 / DSM 5511 / NCIMB 13204 / VKM B-1734Imported.

Entry informationi

Entry nameiD2RSK7_HALTV
AccessioniPrimary (citable) accession number: D2RSK7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: April 29, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.