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Protein

Proteasome subunit beta 1

Gene

psmB1

Organism
Haloterrigena turkmenica (strain ATCC 51198 / DSM 5511 / NCIMB 13204 / VKM B-1734) (Halococcus turkmenicus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

Enzyme regulationi

The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei49NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Protein family/group databases

MEROPSiT01.002

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta 1UniRule annotation (EC:3.4.25.1UniRule annotation)
Alternative name(s):
20S proteasome beta subunit 1UniRule annotation
Proteasome core protein PsmB 1UniRule annotation
Gene namesi
Name:psmB1UniRule annotation
Ordered Locus Names:Htur_1568
OrganismiHaloterrigena turkmenica (strain ATCC 51198 / DSM 5511 / NCIMB 13204 / VKM B-1734) (Halococcus turkmenicus)
Taxonomic identifieri543526 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaNatrialbalesNatrialbaceaeHaloterrigena
Proteomesi
  • UP000001903 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00003973101 – 48Removed in mature form; by autocatalysisUniRule annotationAdd BLAST48
ChainiPRO_000039731149 – 243Proteasome subunit beta 1Add BLAST195

Keywords - PTMi

Autocatalytic cleavage, Zymogen

Interactioni

Subunit structurei

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.UniRule annotation

Protein-protein interaction databases

STRINGi543526.Htur_1568

Structurei

3D structure databases

SMRiD2RQX3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00970 Archaea
COG0638 LUCA
HOGENOMiHOG000091083
KOiK03433
OMAiTMCAGVT
OrthoDBiPOG093Z0CM8

Family and domain databases

Gene3Di3.60.20.10, 1 hit
HAMAPiMF_02113_A Proteasome_B_A, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR019983 Pept_T1A_Psome_bsu_arc
IPR000243 Pept_T1A_subB
IPR001353 Proteasome_sua/b
IPR023333 Proteasome_suB-type
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PRINTSiPR00141 PROTEASOME
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR03634 arc_protsome_B, 1 hit
PROSITEiView protein in PROSITE
PS51476 PROTEASOME_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D2RQX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAPQHNSDF SRTVDQLADD PNPYEPEIGS MPQNDLTRAD LDNVNKTGTT
60 70 80 90 100
TIGISTADGV VIATDMRASL GGRFVSNKNV QKVEQIHPTG ALTLVGSVGG
110 120 130 140 150
AQSFISSLRA EVNLYESRRG EQMSIDALAT LAGNFARGGP FFAIHPILGG
160 170 180 190 200
VDEEGSHVYS IDPAGGVMED DYTVTGSGMQ LAYGHLEQAY EEDMSNEEAV
210 220 230 240
SVAAHGIKSA VERDTGSGNG VFLCEITDEG VDIHGHHDFD EVL
Length:243
Mass (Da):25,825
Last modified:March 2, 2010 - v1
Checksum:iDAA0BA87B20DABA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001860 Genomic DNA Translation: ADB60454.1
RefSeqiWP_012942752.1, NC_013743.1

Genome annotation databases

EnsemblBacteriaiADB60454; ADB60454; Htur_1568
GeneIDi8742159
KEGGihtu:Htur_1568

Similar proteinsi

Entry informationi

Entry nameiPSB1_HALTV
AccessioniPrimary (citable) accession number: D2RQX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: March 2, 2010
Last modified: March 28, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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