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D2RQX3

- PSB1_HALTV

UniProt

D2RQX3 - PSB1_HALTV

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Protein

Proteasome subunit beta 1

Gene

psmB1

Organism
Haloterrigena turkmenica (strain ATCC 51198 / DSM 5511 / NCIMB 13204 / VKM B-1734) (Halococcus turkmenicus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

Enzyme regulationi

The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei49 – 491NucleophileUniRule annotation

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. proteasomal protein catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

BioCyciHTUR543526:GH7B-1596-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta 1UniRule annotation (EC:3.4.25.1UniRule annotation)
Alternative name(s):
20S proteasome beta subunit 1UniRule annotation
Proteasome core protein PsmB 1UniRule annotation
Gene namesi
Name:psmB1UniRule annotation
Ordered Locus Names:Htur_1568
OrganismiHaloterrigena turkmenica (strain ATCC 51198 / DSM 5511 / NCIMB 13204 / VKM B-1734) (Halococcus turkmenicus)
Taxonomic identifieri543526 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloterrigena
ProteomesiUP000001903: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
  2. proteasome core complex, beta-subunit complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 4848Removed in mature form; by autocatalysisUniRule annotationPRO_0000397310Add
BLAST
Chaini49 – 243195Proteasome subunit beta 1PRO_0000397311Add
BLAST

Keywords - PTMi

Autocatalytic cleavage, Zymogen

Interactioni

Subunit structurei

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000091083.
KOiK03433.
OMAiRYHEGIN.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_02113_A. Proteasome_B_A.
InterProiIPR029055. Ntn_hydrolases_N.
IPR019983. Pept_T1A_Psome_bsu_arc.
IPR000243. Pept_T1A_subB.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR03634. arc_protsome_B. 1 hit.
PROSITEiPS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D2RQX3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRAPQHNSDF SRTVDQLADD PNPYEPEIGS MPQNDLTRAD LDNVNKTGTT
60 70 80 90 100
TIGISTADGV VIATDMRASL GGRFVSNKNV QKVEQIHPTG ALTLVGSVGG
110 120 130 140 150
AQSFISSLRA EVNLYESRRG EQMSIDALAT LAGNFARGGP FFAIHPILGG
160 170 180 190 200
VDEEGSHVYS IDPAGGVMED DYTVTGSGMQ LAYGHLEQAY EEDMSNEEAV
210 220 230 240
SVAAHGIKSA VERDTGSGNG VFLCEITDEG VDIHGHHDFD EVL
Length:243
Mass (Da):25,825
Last modified:March 2, 2010 - v1
Checksum:iDAA0BA87B20DABA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001860 Genomic DNA. Translation: ADB60454.1.
RefSeqiYP_003403127.1. NC_013743.1.

Genome annotation databases

EnsemblBacteriaiADB60454; ADB60454; Htur_1568.
GeneIDi8742159.
KEGGihtu:Htur_1568.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001860 Genomic DNA. Translation: ADB60454.1 .
RefSeqi YP_003403127.1. NC_013743.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADB60454 ; ADB60454 ; Htur_1568 .
GeneIDi 8742159.
KEGGi htu:Htur_1568.

Phylogenomic databases

HOGENOMi HOG000091083.
KOi K03433.
OMAi RYHEGIN.

Enzyme and pathway databases

BioCyci HTUR543526:GH7B-1596-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_02113_A. Proteasome_B_A.
InterProi IPR029055. Ntn_hydrolases_N.
IPR019983. Pept_T1A_Psome_bsu_arc.
IPR000243. Pept_T1A_subB.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
[Graphical view ]
PRINTSi PR00141. PROTEASOME.
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR03634. arc_protsome_B. 1 hit.
PROSITEi PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51198 / DSM 5511 / NCIMB 13204 / VKM B-1734.

Entry informationi

Entry nameiPSB1_HALTV
AccessioniPrimary (citable) accession number: D2RQX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: March 2, 2010
Last modified: November 26, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3