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D2RLK1 (D2RLK1_ACIFV) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ATP-dependent zinc metalloprotease FtsH HAMAP-Rule MF_01458
EC=3.4.24.- HAMAP-Rule MF_01458
Gene names
Name:ftsH HAMAP-Rule MF_01458
Ordered Locus Names:Acfer_1596
OrganismAcidaminococcus fermentans (strain ATCC 25085 / DSM 20731 / VR4) [Complete proteome] [HAMAP] EMBL ADB47953.1
Taxonomic identifier591001 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Negativicutes › Selenomonadales › Acidaminococcaceae › Acidaminococcus ›

Protein attributes

Sequence length645 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins By similarity. HAMAP-Rule MF_01458

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01458

Subunit structure

Homohexamer By similarity. HAMAP-Rule MF_01458

Subcellular location

Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side By similarity HAMAP-Rule MF_01458.

Sequence similarities

In the C-terminal section; belongs to the peptidase M41 family. HAMAP-Rule MF_01458

In the central section; belongs to the AAA ATPase family. HAMAP-Rule MF_01458

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Topological domain1 – 77Cytoplasmic By similarity HAMAP-Rule MF_01458
Transmembrane8 – 2821Helical; By similarity HAMAP-Rule MF_01458
Topological domain29 – 10072Periplasmic By similarity HAMAP-Rule MF_01458
Transmembrane101 – 12121Helical; By similarity HAMAP-Rule MF_01458
Topological domain122 – 645524Cytoplasmic By similarity HAMAP-Rule MF_01458
Nucleotide binding194 – 2018ATP By similarity HAMAP-Rule MF_01458

Sites

Active site4171 By similarity HAMAP-Rule MF_01458
Metal binding4161Zinc; catalytic By similarity HAMAP-Rule MF_01458
Metal binding4201Zinc; catalytic By similarity HAMAP-Rule MF_01458
Metal binding4921Zinc; catalytic By similarity HAMAP-Rule MF_01458

Sequences

Sequence LengthMass (Da)Tools
D2RLK1 [UniParc].

Last modified March 2, 2010. Version 1.
Checksum: 2FFBF5D69CE98CAF

FASTA64570,856
        10         20         30         40         50         60 
MSKFIRNLVF YLLIVIVGVW IYDYYNASST PKNEMSYSNF VKEVQQDEVK SVTIVDNSVI 

        70         80         90        100        110        120 
KGKLKNGAEF TTIAPRDEKL VDTLRARDVE IRAELPPQPS MLSNILTSLL PMVVIVILWF 

       130        140        150        160        170        180 
FMMNNAQGGG SRVMSFGKSK AKLYGDGKSR VTFKDVAGAD EAKQELEEVV EFLKAPQKYN 

       190        200        210        220        230        240 
QLGAKIPKGV LLYGPPGTGK TLLAKAVAGE AGVPFFSISG SDFVEMFVGV GASRVRDLFD 

       250        260        270        280        290        300 
QAKKNAPCIV FIDEIDAVGR QRGAGLGGGH DEREQTLNQL LVEMDGFGAN EGIIMIAATN 

       310        320        330        340        350        360 
RPDILDPALL RPGRFDRQIV VDKPDIRGRR SILRVHTKGK PMDPSVDLGV IARQTPGFTG 

       370        380        390        400        410        420 
ADLANLVNEG ALLAARHNQV TITMSDLEEA AERVMMGPER KSRVITDEEK RLTAYHEGGH 

       430        440        450        460        470        480 
TLVGMLLDHT DPVHKVTIIP RGRAGGYTLS LPTEDRYYAT RSEMLDQLKV LLGGRVAEAL 

       490        500        510        520        530        540 
VLHEISSGAS SDLQRATELA RRMTCEYGMS DVLGAVTFGH RQEQVFLGRD IGRQNDYSEK 

       550        560        570        580        590        600 
VAAQIDGEIR RFIDEAYEGT VKLLTDNMDK LHLIAKNLME RETLEGHEIE ELLKYGHILE 

       610        620        630        640 
KGEVPPQEEP EKPADGTPAP VGPLPAEEPA EAPVMAPVPK EVPEG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001859 Genomic DNA. Translation: ADB47953.1.
RefSeqYP_003399268.1. NC_013740.1.

3D structure databases

ProteinModelPortalD2RLK1.
ModBaseSearch...

Protein family/group databases

MEROPSM41.021.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADB47953; ADB47953; Acfer_1596.
GeneID8738089.
KEGGafn:Acfer_1596.
PATRIC31909751. VBIAciFer109666_1580.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000217277.
KOK03798.
OMATGKADDE.

Enzyme and pathway databases

BioCycAFER591001:GHUL-1659-MONOMER.

Family and domain databases

HAMAPMF_01458. FtsH.
InterProIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR005936. FtsH.
IPR011546. Pept_M41_FtsH_extracell.
IPR000642. Peptidase_M41.
[Graphical view]
PfamPF00004. AAA. 1 hit.
PF06480. FtsH_ext. 1 hit.
PF01434. Peptidase_M41. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
TIGRFAMsTIGR01241. FtsH_fam. 1 hit.
PROSITEPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD2RLK1_ACIFV
AccessionPrimary (citable) accession number: D2RLK1
Entry history
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: May 1, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info