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D2RKQ9 (D2RKQ9_ACIFV) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Acfer_1300 EMBL ADB47661.1
OrganismAcidaminococcus fermentans (strain ATCC 25085 / DSM 20731 / VR4) [Complete proteome] [HAMAP] EMBL ADB47661.1
Taxonomic identifier591001 [NCBI]
Taxonomic lineageBacteriaFirmicutesNegativicutesSelenomonadalesAcidaminococcaceaeAcidaminococcus

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain104 – 307204ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding133 – 18856ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2611Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2741Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2741Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2761Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
D2RKQ9 [UniParc].

Last modified March 2, 2010. Version 1.
Checksum: E70DA36C08D3C077

FASTA31033,407
        10         20         30         40         50         60 
MDKKDRVAVV MGGPSKEREV SLNTGNAILN ALKEKGYDAV AIDLDPEHIV DQLKASGARV 

        70         80         90        100        110        120 
VFNAVHGLYG EDGRLQGILE MLGIPYTGSG VLASALAMDK VYTKHLFQNN HVPTARCIFL 

       130        140        150        160        170        180 
DKKRDQDPKA RILEEIGIPC VVKPATQGSS IGVVIVKDEK QLDDALQEAF QYGDHVLCEA 

       190        200        210        220        230        240 
FFTGKEVAAG VMMGEDGRAV PMPLVLIEPH VNFYDFHNKY TKGATTYTCP APFDAETTRR 

       250        260        270        280        290        300 
LQKIAVAAYE ALGCSGVART DLMLADNGDC IALEVNTIPG MTATSLIPKA AAAMGISFPD 

       310 
LCEKILKTAH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001859 Genomic DNA. Translation: ADB47661.1.
RefSeqYP_003398976.1. NC_013740.1.

3D structure databases

ProteinModelPortalD2RKQ9.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADB47661; ADB47661; Acfer_1300.
GeneID8737785.
KEGGafn:Acfer_1300.
PATRIC31909129. VBIAciFer109666_1276.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011592.
KOK01921.
OMAANDTQYR.

Enzyme and pathway databases

BioCycAFER591001:GHUL-1355-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD2RKQ9_ACIFV
AccessionPrimary (citable) accession number: D2RKQ9
Entry history
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: June 11, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)