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Protein

DNA ligase

Gene

lig

Organism
Archaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei247 – 2471ATPUniRule annotation
Active sitei249 – 2491N6-AMP-lysine intermediateUniRule annotation
Binding sitei254 – 2541ATPUniRule annotation
Binding sitei269 – 2691ATPUniRule annotation
Binding sitei298 – 2981ATPUniRule annotation
Binding sitei337 – 3371ATPUniRule annotation
Binding sitei411 – 4111ATPUniRule annotation
Binding sitei417 – 4171ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciAPRO572546:GJI1-562-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Arcpr_0546Imported
OrganismiArchaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18)Imported
Taxonomic identifieri572546 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
ProteomesiUP000001901 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi572546.Arcpr_0546.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK10747.
OMAiGRPRPFQ.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D2RH37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFREFAEFC AILERVSSTL EMTGRIASFL RRIEDDDDLY NVVHFLMGRV
60 70 80 90 100
FPPWDERELG VGIGLVCKAL ENVSGVSKEK IESMIKDYGD LGLVAERLLK
110 120 130 140 150
GRGIKSLFAE ELTIKRVREI FDEIASLEGE GSQKRKILLL TGLYGSASPI
160 170 180 190 200
EARYLTRLIL GEMRLGVGEG IMRDAIARAW GVDAELVERA YMIVNDLGRV
210 220 230 240 250
AIIAKNEGKE GLKNVKIQLH IPVKMMLAQV AESIEQALRE MKTIAVEWKY
260 270 280 290 300
DGSRVQVHYG NGKVTIYSRR LENVTKALPE IVEEIKKCVK EGVILDGEVI
310 320 330 340 350
AVKDGKPMPF QEVLRRFRRK HEITKAMEKI PLEAYFFDIL YNDGEVIDLP
360 370 380 390 400
LKERRKILES VIKESKIIKI AKQVVTNKKE EIERVFKEAL DAGHEGAMLK
410 420 430 440 450
NPNSPYTPGK RGRHWLKLKE VMETLDLVVV GGEWGEGRRS HLISSFELAC
460 470 480 490 500
LDPRTGKLLR IGQVGTGFTD EDLEELTELF KPLIVKEEGK KVYFKPKIVF
510 520 530 540 550
EVAYQEIQKS PKYESGFALR FPRFVRLRDD KGVEDADTID RVRELYEKQF

ARAKS
Length:555
Mass (Da):63,323
Last modified:March 2, 2010 - v1
Checksum:iCAC9EDE305B7C49B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001857 Genomic DNA. Translation: ADB57612.1.
RefSeqiWP_012939948.1. NC_013741.1.
YP_003400285.1. NC_013741.1.

Genome annotation databases

EnsemblBacteriaiADB57612; ADB57612; Arcpr_0546.
GeneIDi8739205.
KEGGiapo:Arcpr_0546.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001857 Genomic DNA. Translation: ADB57612.1.
RefSeqiWP_012939948.1. NC_013741.1.
YP_003400285.1. NC_013741.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi572546.Arcpr_0546.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADB57612; ADB57612; Arcpr_0546.
GeneIDi8739205.
KEGGiapo:Arcpr_0546.

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK10747.
OMAiGRPRPFQ.

Enzyme and pathway databases

BioCyciAPRO572546:GJI1-562-MONOMER.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 5631 / JCM 9629 / NBRC 100127 / Av18Imported.

Entry informationi

Entry nameiD2RH37_ARCPA
AccessioniPrimary (citable) accession number: D2RH37
Entry historyi
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: June 24, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.