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Protein

DNA ligase

Gene

lig

Organism
Archaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei247ATPUniRule annotation1
Active sitei249N6-AMP-lysine intermediateUniRule annotation1
Binding sitei254ATPUniRule annotation1
Binding sitei269ATPUniRule annotation1
Binding sitei298ATPUniRule annotation1
Binding sitei337ATPUniRule annotation1
Binding sitei411ATPUniRule annotation1
Binding sitei417ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciAPRO572546:G1GH6-548-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Arcpr_0546Imported
OrganismiArchaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18)Imported
Taxonomic identifieri572546 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000001901 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi572546.Arcpr_0546

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini325 – 452DNA_LIGASE_A3InterPro annotationAdd BLAST128

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
HOGENOMiHOG000036008
KOiK10747
OMAiWLFEESY
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

D2RH37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFREFAEFC AILERVSSTL EMTGRIASFL RRIEDDDDLY NVVHFLMGRV
60 70 80 90 100
FPPWDERELG VGIGLVCKAL ENVSGVSKEK IESMIKDYGD LGLVAERLLK
110 120 130 140 150
GRGIKSLFAE ELTIKRVREI FDEIASLEGE GSQKRKILLL TGLYGSASPI
160 170 180 190 200
EARYLTRLIL GEMRLGVGEG IMRDAIARAW GVDAELVERA YMIVNDLGRV
210 220 230 240 250
AIIAKNEGKE GLKNVKIQLH IPVKMMLAQV AESIEQALRE MKTIAVEWKY
260 270 280 290 300
DGSRVQVHYG NGKVTIYSRR LENVTKALPE IVEEIKKCVK EGVILDGEVI
310 320 330 340 350
AVKDGKPMPF QEVLRRFRRK HEITKAMEKI PLEAYFFDIL YNDGEVIDLP
360 370 380 390 400
LKERRKILES VIKESKIIKI AKQVVTNKKE EIERVFKEAL DAGHEGAMLK
410 420 430 440 450
NPNSPYTPGK RGRHWLKLKE VMETLDLVVV GGEWGEGRRS HLISSFELAC
460 470 480 490 500
LDPRTGKLLR IGQVGTGFTD EDLEELTELF KPLIVKEEGK KVYFKPKIVF
510 520 530 540 550
EVAYQEIQKS PKYESGFALR FPRFVRLRDD KGVEDADTID RVRELYEKQF

ARAKS
Length:555
Mass (Da):63,323
Last modified:March 2, 2010 - v1
Checksum:iCAC9EDE305B7C49B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001857 Genomic DNA Translation: ADB57612.1
RefSeqiWP_012939948.1, NC_013741.1

Genome annotation databases

EnsemblBacteriaiADB57612; ADB57612; Arcpr_0546
GeneIDi8739205
KEGGiapo:Arcpr_0546

Similar proteinsi

Entry informationi

Entry nameiD2RH37_ARCPA
AccessioniPrimary (citable) accession number: D2RH37
Entry historyiIntegrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: March 28, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health