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D2RH37

- D2RH37_ARCPA

UniProt

D2RH37 - D2RH37_ARCPA

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Protein
DNA ligase
Gene
lig, Arcpr_0546
Organism
Archaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei247 – 2471ATP By similarityUniRule annotation
Active sitei249 – 2491N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei254 – 2541ATP By similarityUniRule annotation
Binding sitei269 – 2691ATP By similarityUniRule annotation
Binding sitei298 – 2981ATP By similarityUniRule annotation
Binding sitei337 – 3371ATP By similarityUniRule annotation
Binding sitei411 – 4111ATP By similarityUniRule annotation
Binding sitei417 – 4171ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciAPRO572546:GJI1-562-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Arcpr_0546Imported
OrganismiArchaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18)Imported
Taxonomic identifieri572546 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
ProteomesiUP000001901: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK10747.
OMAiARVQVHK.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D2RH37-1 [UniParc]FASTAAdd to Basket

« Hide

MKFREFAEFC AILERVSSTL EMTGRIASFL RRIEDDDDLY NVVHFLMGRV    50
FPPWDERELG VGIGLVCKAL ENVSGVSKEK IESMIKDYGD LGLVAERLLK 100
GRGIKSLFAE ELTIKRVREI FDEIASLEGE GSQKRKILLL TGLYGSASPI 150
EARYLTRLIL GEMRLGVGEG IMRDAIARAW GVDAELVERA YMIVNDLGRV 200
AIIAKNEGKE GLKNVKIQLH IPVKMMLAQV AESIEQALRE MKTIAVEWKY 250
DGSRVQVHYG NGKVTIYSRR LENVTKALPE IVEEIKKCVK EGVILDGEVI 300
AVKDGKPMPF QEVLRRFRRK HEITKAMEKI PLEAYFFDIL YNDGEVIDLP 350
LKERRKILES VIKESKIIKI AKQVVTNKKE EIERVFKEAL DAGHEGAMLK 400
NPNSPYTPGK RGRHWLKLKE VMETLDLVVV GGEWGEGRRS HLISSFELAC 450
LDPRTGKLLR IGQVGTGFTD EDLEELTELF KPLIVKEEGK KVYFKPKIVF 500
EVAYQEIQKS PKYESGFALR FPRFVRLRDD KGVEDADTID RVRELYEKQF 550
ARAKS 555
Length:555
Mass (Da):63,323
Last modified:March 2, 2010 - v1
Checksum:iCAC9EDE305B7C49B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001857 Genomic DNA. Translation: ADB57612.1.
RefSeqiWP_012939948.1. NC_013741.1.
YP_003400285.1. NC_013741.1.

Genome annotation databases

EnsemblBacteriaiADB57612; ADB57612; Arcpr_0546.
GeneIDi8739205.
KEGGiapo:Arcpr_0546.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001857 Genomic DNA. Translation: ADB57612.1 .
RefSeqi WP_012939948.1. NC_013741.1.
YP_003400285.1. NC_013741.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADB57612 ; ADB57612 ; Arcpr_0546 .
GeneIDi 8739205.
KEGGi apo:Arcpr_0546.

Phylogenomic databases

HOGENOMi HOG000036008.
KOi K10747.
OMAi ARVQVHK.

Enzyme and pathway databases

BioCyci APRO572546:GJI1-562-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 5631 / JCM 9629 / NBRC 100127 / Av18.

Entry informationi

Entry nameiD2RH37_ARCPA
AccessioniPrimary (citable) accession number: D2RH37
Entry historyi
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: September 3, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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