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D2RH37 (D2RH37_ARCPA) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA ligase HAMAP-Rule MF_00407 RuleBase RU000617

EC=6.5.1.1 HAMAP-Rule MF_00407 RuleBase RU000617
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] HAMAP-Rule MF_00407
Gene names
Name:lig HAMAP-Rule MF_00407
Ordered Locus Names:Arcpr_0546 EMBL ADB57612.1
OrganismArchaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18) [Complete proteome] [HAMAP] EMBL ADB57612.1
Taxonomic identifier572546 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus

Protein attributes

Sequence length555 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407 RuleBase RU000617

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family. HAMAP-Rule MF_00407

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2491N6-AMP-lysine intermediate By similarity HAMAP-Rule MF_00407
Binding site2471ATP By similarity HAMAP-Rule MF_00407
Binding site2541ATP By similarity HAMAP-Rule MF_00407
Binding site2691ATP By similarity HAMAP-Rule MF_00407
Binding site2981ATP By similarity HAMAP-Rule MF_00407
Binding site3371ATP By similarity HAMAP-Rule MF_00407
Binding site4111ATP By similarity HAMAP-Rule MF_00407
Binding site4171ATP By similarity HAMAP-Rule MF_00407

Sequences

Sequence LengthMass (Da)Tools
D2RH37 [UniParc].

Last modified March 2, 2010. Version 1.
Checksum: CAC9EDE305B7C49B

FASTA55563,323
        10         20         30         40         50         60 
MKFREFAEFC AILERVSSTL EMTGRIASFL RRIEDDDDLY NVVHFLMGRV FPPWDERELG 

        70         80         90        100        110        120 
VGIGLVCKAL ENVSGVSKEK IESMIKDYGD LGLVAERLLK GRGIKSLFAE ELTIKRVREI 

       130        140        150        160        170        180 
FDEIASLEGE GSQKRKILLL TGLYGSASPI EARYLTRLIL GEMRLGVGEG IMRDAIARAW 

       190        200        210        220        230        240 
GVDAELVERA YMIVNDLGRV AIIAKNEGKE GLKNVKIQLH IPVKMMLAQV AESIEQALRE 

       250        260        270        280        290        300 
MKTIAVEWKY DGSRVQVHYG NGKVTIYSRR LENVTKALPE IVEEIKKCVK EGVILDGEVI 

       310        320        330        340        350        360 
AVKDGKPMPF QEVLRRFRRK HEITKAMEKI PLEAYFFDIL YNDGEVIDLP LKERRKILES 

       370        380        390        400        410        420 
VIKESKIIKI AKQVVTNKKE EIERVFKEAL DAGHEGAMLK NPNSPYTPGK RGRHWLKLKE 

       430        440        450        460        470        480 
VMETLDLVVV GGEWGEGRRS HLISSFELAC LDPRTGKLLR IGQVGTGFTD EDLEELTELF 

       490        500        510        520        530        540 
KPLIVKEEGK KVYFKPKIVF EVAYQEIQKS PKYESGFALR FPRFVRLRDD KGVEDADTID 

       550 
RVRELYEKQF ARAKS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001857 Genomic DNA. Translation: ADB57612.1.
RefSeqYP_003400285.1. NC_013741.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADB57612; ADB57612; Arcpr_0546.
GeneID8739205.
KEGGapo:Arcpr_0546.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000036008.
KOK10747.
OMAARVQVHK.

Enzyme and pathway databases

BioCycAPRO572546:GJI1-562-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD2RH37_ARCPA
AccessionPrimary (citable) accession number: D2RH37
Entry history
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: June 11, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)