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D2RH37

- D2RH37_ARCPA

UniProt

D2RH37 - D2RH37_ARCPA

Protein

DNA ligase

Gene

lig

Organism
Archaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (02 Mar 2010)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei247 – 2471ATPUniRule annotation
    Active sitei249 – 2491N6-AMP-lysine intermediateUniRule annotation
    Binding sitei254 – 2541ATPUniRule annotation
    Binding sitei269 – 2691ATPUniRule annotation
    Binding sitei298 – 2981ATPUniRule annotation
    Binding sitei337 – 3371ATPUniRule annotation
    Binding sitei411 – 4111ATPUniRule annotation
    Binding sitei417 – 4171ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAPRO572546:GJI1-562-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:Arcpr_0546Imported
    OrganismiArchaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18)Imported
    Taxonomic identifieri572546 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
    ProteomesiUP000001901: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000036008.
    KOiK10747.
    OMAiARVQVHK.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D2RH37-1 [UniParc]FASTAAdd to Basket

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    MKFREFAEFC AILERVSSTL EMTGRIASFL RRIEDDDDLY NVVHFLMGRV    50
    FPPWDERELG VGIGLVCKAL ENVSGVSKEK IESMIKDYGD LGLVAERLLK 100
    GRGIKSLFAE ELTIKRVREI FDEIASLEGE GSQKRKILLL TGLYGSASPI 150
    EARYLTRLIL GEMRLGVGEG IMRDAIARAW GVDAELVERA YMIVNDLGRV 200
    AIIAKNEGKE GLKNVKIQLH IPVKMMLAQV AESIEQALRE MKTIAVEWKY 250
    DGSRVQVHYG NGKVTIYSRR LENVTKALPE IVEEIKKCVK EGVILDGEVI 300
    AVKDGKPMPF QEVLRRFRRK HEITKAMEKI PLEAYFFDIL YNDGEVIDLP 350
    LKERRKILES VIKESKIIKI AKQVVTNKKE EIERVFKEAL DAGHEGAMLK 400
    NPNSPYTPGK RGRHWLKLKE VMETLDLVVV GGEWGEGRRS HLISSFELAC 450
    LDPRTGKLLR IGQVGTGFTD EDLEELTELF KPLIVKEEGK KVYFKPKIVF 500
    EVAYQEIQKS PKYESGFALR FPRFVRLRDD KGVEDADTID RVRELYEKQF 550
    ARAKS 555
    Length:555
    Mass (Da):63,323
    Last modified:March 2, 2010 - v1
    Checksum:iCAC9EDE305B7C49B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001857 Genomic DNA. Translation: ADB57612.1.
    RefSeqiWP_012939948.1. NC_013741.1.
    YP_003400285.1. NC_013741.1.

    Genome annotation databases

    EnsemblBacteriaiADB57612; ADB57612; Arcpr_0546.
    GeneIDi8739205.
    KEGGiapo:Arcpr_0546.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001857 Genomic DNA. Translation: ADB57612.1 .
    RefSeqi WP_012939948.1. NC_013741.1.
    YP_003400285.1. NC_013741.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADB57612 ; ADB57612 ; Arcpr_0546 .
    GeneIDi 8739205.
    KEGGi apo:Arcpr_0546.

    Phylogenomic databases

    HOGENOMi HOG000036008.
    KOi K10747.
    OMAi ARVQVHK.

    Enzyme and pathway databases

    BioCyci APRO572546:GJI1-562-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 5631 / JCM 9629 / NBRC 100127 / Av18Imported.

    Entry informationi

    Entry nameiD2RH37_ARCPA
    AccessioniPrimary (citable) accession number: D2RH37
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 2, 2010
    Last sequence update: March 2, 2010
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3