ID D2RGN4_ARCPA Unreviewed; 305 AA. AC D2RGN4; DT 02-MAR-2010, integrated into UniProtKB/TrEMBL. DT 02-MAR-2010, sequence version 1. DT 27-MAR-2024, entry version 81. DE RecName: Full=ornithine carbamoyltransferase {ECO:0000256|ARBA:ARBA00013007}; DE EC=2.1.3.3 {ECO:0000256|ARBA:ARBA00013007}; GN OrderedLocusNames=Arcpr_0390 {ECO:0000313|EMBL:ADB57459.1}; OS Archaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18). OC Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae; OC Archaeoglobus. OX NCBI_TaxID=572546 {ECO:0000313|EMBL:ADB57459.1, ECO:0000313|Proteomes:UP000001901}; RN [1] {ECO:0000313|EMBL:ADB57459.1, ECO:0000313|Proteomes:UP000001901} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=DSM 5631 / JCM 9629 / NBRC 100127 / Av18 RC {ECO:0000313|Proteomes:UP000001901}; RX PubMed=21304717; RA von Jan M., Lapidus A., Del Rio T.G., Copeland A., Tice H., Cheng J.F., RA Lucas S., Chen F., Nolan M., Goodwin L., Han C., Pitluck S., Liolios K., RA Ivanova N., Mavromatis K., Ovchinnikova G., Chertkov O., Pati A., Chen A., RA Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D., Saunders E., RA Brettin T., Detter J.C., Chain P., Eichinger K., Huber H., Spring S., RA Rohde M., Goker M., Wirth R., Woyke T., Bristow J., Eisen J.A., RA Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.; RT "Complete genome sequence of Archaeoglobus profundus type strain (AV18)."; RL Stand. Genomic Sci. 2:327-346(2010). CC -!- CATALYTIC ACTIVITY: CC Reaction=carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + CC phosphate; Xref=Rhea:RHEA:19513, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:46911, ChEBI:CHEBI:57743, CC ChEBI:CHEBI:58228; EC=2.1.3.3; CC Evidence={ECO:0000256|ARBA:ARBA00001065, ECO:0000256|HAMAP- CC Rule:MF_01109}; CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01109}. CC -!- SIMILARITY: Belongs to the aspartate/ornithine carbamoyltransferase CC superfamily. OTCase family. {ECO:0000256|ARBA:ARBA00007805, CC ECO:0000256|HAMAP-Rule:MF_01109}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP001857; ADB57459.1; -; Genomic_DNA. DR RefSeq; WP_012939795.1; NC_013741.1. DR AlphaFoldDB; D2RGN4; -. DR STRING; 572546.Arcpr_0390; -. DR PaxDb; 572546-Arcpr_0390; -. DR GeneID; 8739046; -. DR KEGG; apo:Arcpr_0390; -. DR eggNOG; arCOG00912; Archaea. DR HOGENOM; CLU_043846_3_2_2; -. DR OrthoDB; 4696at2157; -. DR Proteomes; UP000001901; Chromosome. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0016597; F:amino acid binding; IEA:InterPro. DR GO; GO:0004585; F:ornithine carbamoyltransferase activity; IEA:UniProtKB-UniRule. DR Gene3D; 3.40.50.1370; Aspartate/ornithine carbamoyltransferase; 2. DR HAMAP; MF_01109; OTCase; 1. DR InterPro; IPR006132; Asp/Orn_carbamoyltranf_P-bd. DR InterPro; IPR006130; Asp/Orn_carbamoylTrfase. DR InterPro; IPR036901; Asp/Orn_carbamoylTrfase_sf. DR InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn-bd. DR InterPro; IPR002292; Orn/put_carbamltrans. DR InterPro; IPR024904; OTCase_ArgI. DR NCBIfam; TIGR00658; orni_carb_tr; 1. DR PANTHER; PTHR45753; ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL; 1. DR PANTHER; PTHR45753:SF3; ORNITHINE TRANSCARBAMYLASE, MITOCHONDRIAL; 1. DR Pfam; PF00185; OTCace; 1. DR Pfam; PF02729; OTCace_N; 1. DR PRINTS; PR00100; AOTCASE. DR PRINTS; PR00102; OTCASE. DR SUPFAM; SSF53671; Aspartate/ornithine carbamoyltransferase; 1. PE 3: Inferred from homology; KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01109}; KW Reference proteome {ECO:0000313|Proteomes:UP000001901}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP- KW Rule:MF_01109}. FT DOMAIN 2..142 FT /note="Aspartate/ornithine carbamoyltransferase carbamoyl-P FT binding" FT /evidence="ECO:0000259|Pfam:PF02729" FT DOMAIN 150..297 FT /note="Aspartate/ornithine carbamoyltransferase Asp/Orn- FT binding" FT /evidence="ECO:0000259|Pfam:PF00185" FT BINDING 51..54 FT /ligand="carbamoyl phosphate" FT /ligand_id="ChEBI:CHEBI:58228" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01109" FT BINDING 78 FT /ligand="carbamoyl phosphate" FT /ligand_id="ChEBI:CHEBI:58228" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01109" FT BINDING 102 FT /ligand="carbamoyl phosphate" FT /ligand_id="ChEBI:CHEBI:58228" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01109" FT BINDING 129..132 FT /ligand="carbamoyl phosphate" FT /ligand_id="ChEBI:CHEBI:58228" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01109" FT BINDING 160 FT /ligand="L-ornithine" FT /ligand_id="ChEBI:CHEBI:46911" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01109" FT BINDING 220 FT /ligand="L-ornithine" FT /ligand_id="ChEBI:CHEBI:46911" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01109" FT BINDING 224..225 FT /ligand="L-ornithine" FT /ligand_id="ChEBI:CHEBI:46911" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01109" FT BINDING 260..261 FT /ligand="carbamoyl phosphate" FT /ligand_id="ChEBI:CHEBI:58228" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01109" FT BINDING 288 FT /ligand="carbamoyl phosphate" FT /ligand_id="ChEBI:CHEBI:58228" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01109" SQ SEQUENCE 305 AA; 34595 MW; DDA5E61372C3C38C CRC64; MKHLISMADL TPEELEEILK LAEKLKEERY KGRVTDYLKN KSLAMIFELP STRTRISFEV AMTDLGGHAL YLNWNDLQLG RGEPIKDTAR VLSRYVHAVM MRVRKHETIL EFAKYSTVPV INGLSDLEHP CQVIADLLTI KEYKGDLKSV RLTWIGDGNN VCNSLILASA LTGMEMVVCT PKGYEPNKEI VEKALKMGAK LTFESDPLKA VENADVIYTD VWVSMGQERE RRKRLKAFTG YQVTQKLVDS AKTNVVVMHC LPAHRGEEIT EEVLEGEHSI VFDQAENRLH AQKAILLKLI GKEKE //