D2RGN4 (D2RGN4_ARCPA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Ornithine carbamoyltransferase, catabolic HAMAP-Rule MF_01109
Short name=OTCase HAMAP-Rule MF_01109
EC=2.1.3.3 HAMAP-Rule MF_01109

Alternative name(s):
Ornithine carbamoyltransferase HAMAP-Rule MF_01109

Gene names

Name:	arcB HAMAP-Rule MF_01109
Ordered Locus Names:	Arcpr_0390

Organism

Archaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18) [Complete proteome] [HAMAP] EMBL ADB57459.1

Taxonomic identifier

572546 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus › Archaeoglobus profundus

Protein attributes

Sequence length	305 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP-Rule MF_01109
Pathway	Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP-Rule MF_01109
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family. HAMAP-Rule MF_01109 RuleBase RU003634

Ontologies

Keywords
Biological process	Arginine metabolism HAMAP-Rule MF_01109
Cellular component	Cytoplasm HAMAP-Rule MF_01109
Molecular function	Transferase HAMAP-Rule MF_01109 RuleBase RU003634 EMBL ADB57459.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	arginine catabolic process to ornithine Inferred from electronic annotation. Source: UniProtKB-UniPathway arginine deiminase pathway Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	51 – 55	5	Carbamoyl phosphate binding By similarity HAMAP-Rule MF_01109
	Region	259 – 262	4	Ornithine binding By similarity HAMAP-Rule MF_01109
Sites
	Binding site	102	1	Carbamoyl phosphate By similarity HAMAP-Rule MF_01109
	Binding site	129	1	Carbamoyl phosphate By similarity HAMAP-Rule MF_01109
	Site	26	1	Important for structural integrity By similarity HAMAP-Rule MF_01109
	Site	142	1	Important for structural integrity By similarity HAMAP-Rule MF_01109

Sequences

	Sequence		Length	Mass (Da)
	D2RGN4 [UniParc]. Last modified March 2, 2010. Version 1. Checksum: DDA5E61372C3C38C	FASTA	305	34,595
	10 20 30 40 50 60 MKHLISMADL TPEELEEILK LAEKLKEERY KGRVTDYLKN KSLAMIFELP STRTRISFEV 70 80 90 100 110 120 AMTDLGGHAL YLNWNDLQLG RGEPIKDTAR VLSRYVHAVM MRVRKHETIL EFAKYSTVPV 130 140 150 160 170 180 INGLSDLEHP CQVIADLLTI KEYKGDLKSV RLTWIGDGNN VCNSLILASA LTGMEMVVCT 190 200 210 220 230 240 PKGYEPNKEI VEKALKMGAK LTFESDPLKA VENADVIYTD VWVSMGQERE RRKRLKAFTG 250 260 270 280 290 300 YQVTQKLVDS AKTNVVVMHC LPAHRGEEIT EEVLEGEHSI VFDQAENRLH AQKAILLKLI GKEKE

References

[1]

"Complete genome sequence of Archaeoglobus profundus type strain (AV18)." von Jan M., Lapidus A., Glavina del Rio T., Copeland A., Tice H., Cheng J.-F., Lucas S., Chen F., Nolan M., Goodwin L., Han C., Pitluck S., Liolios K., Ivanova N., Mavromatis K., Ovchinnikova G., Chertkov O., Pati A. , Chen A., Palaniappan K., Land M., Hauser L., Chang Y.-J., Jeffries C.D., Saunders E., Brettin T., Detter J.C., Chain P., Eichinger K., Huber H., Spring S., Rohde M., Goker M., Wirth R., Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N., Klenk H.-P. Stand. Genomic Sci. 2:327-346(2010) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 5631 / JCM 9629 / NBRC 100127 / Av18.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001857 Genomic DNA. Translation: ADB57459.1.
RefSeq	YP_003400132.1. NC_013741.1.
3D structure databases
ProteinModelPortal	D2RGN4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADB57459; ADB57459; Arcpr_0390.
GeneID	8739046.
KEGG	apo:Arcpr_0390.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000022686.
KO	K00611.
OMA	AHPCQTL.
Enzyme and pathway databases
BioCyc	APRO572546:GJI1-403-MONOMER.
UniPathway	UPA00254; UER00365.
Family and domain databases
HAMAP	MF_01109. OTCase.
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002292. Orn/put_carbamltrans. IPR024904. Orn_carbamltrans. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00658. orni_carb_tr. 1 hit.
ProtoNet	Search...

Entry information

Entry name

D2RGN4_ARCPA

Accession

Primary (citable) accession number: D2RGN4

Entry history

Integrated into UniProtKB/TrEMBL:	March 2, 2010
Last sequence update:	March 2, 2010
Last modified:	May 1, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)