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D2REY6

- D2REY6_ARCPA

UniProt

D2REY6 - D2REY6_ARCPA

Protein

Ribulose bisphosphate carboxylase

Gene

rbcL

Organism
Archaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (02 Mar 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the addition of molecular CO2 and H2O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.UniRule annotation

    Catalytic activityi

    2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
    3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei166 – 1661Proton acceptorUniRule annotation
    Binding sitei168 – 1681SubstrateUniRule annotation
    Metal bindingi192 – 1921Magnesium; via carbamate groupUniRule annotation
    Metal bindingi194 – 1941MagnesiumUniRule annotation
    Metal bindingi195 – 1951MagnesiumUniRule annotation
    Active sitei284 – 2841Proton acceptorUniRule annotation
    Binding sitei285 – 2851SubstrateUniRule annotation
    Binding sitei317 – 3171SubstrateUniRule annotation
    Sitei325 – 3251Transition state stabilizerUniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. oxidoreductase activity Source: UniProtKB-KW
    3. ribulose-bisphosphate carboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. AMP catabolic process Source: UniProtKB-HAMAP
    2. carbon fixation Source: UniProtKB-KW

    Keywords - Molecular functioni

    LyaseUniRule annotationImported, OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Carbon dioxide fixationUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciAPRO572546:GJI1-1685-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
    Short name:
    RuBisCOUniRule annotation
    Gene namesi
    Name:rbcLUniRule annotation
    Ordered Locus Names:Arcpr_1634Imported
    OrganismiArchaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18)Imported
    Taxonomic identifieri572546 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
    ProteomesiUP000001901: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei192 – 1921N6-carboxylysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD2REY6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni370 – 3723Substrate bindingUniRule annotation
    Regioni392 – 3954Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the RuBisCO large chain family. Type III subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000230831.
    KOiK01601.
    OMAiFTQDWAS.

    Family and domain databases

    Gene3Di3.20.20.110. 1 hit.
    3.30.70.150. 1 hit.
    HAMAPiMF_01133. RuBisCO_L_type3.
    InterProiIPR017712. RuBisCO_III.
    IPR000685. RuBisCO_lsu_C.
    IPR017443. RuBisCO_lsu_fd_N.
    IPR017444. RuBisCO_lsu_N.
    [Graphical view]
    PfamiPF00016. RuBisCO_large. 1 hit.
    PF02788. RuBisCO_large_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF51649. SSF51649. 1 hit.
    SSF54966. SSF54966. 1 hit.
    TIGRFAMsiTIGR03326. rubisco_III. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D2REY6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLHRTRVMPD FEMYFEYVDK SYEPSERDLI AVFRVKPSEG FKIEDVAGAI    50
    ASESSTGTWT TLYDWCDKDR IKKLSAKAYE FIDLEDGSWI VKIAYPVELF 100
    ERGSITCLLA SIAGNIFGMK RVAGLRLEDV YLPKEFLKYF EGPNFGKDVR 150
    KIFKVYDRPI VGTVPKPKVG YTPDEVEKLA YELLSGGMDY IKDDENLTSQ 200
    DFCKFEERAK AIMKAIDKAE SDTGEKKVWF ANITGDVKEM EKRMKIVADY 250
    GNPYVMIDVV IAGWSVLKYM RELANDYGLA IHAHRAMHSA FTRNRYHGIS 300
    MFVLAKLYRV IGVDQLHIGT AGYGKLEGGM WEVVQYAKIL RESSYVPDEK 350
    DIFHIKQEFH HIKPAMPVSS GGLHPGNVAG VIDALGEDII IQVGGGVMGH 400
    PDGPKAGAKA VRQALEAIKL GIPLDEYAKD HKELAKALEK WGYVKPV 447
    Length:447
    Mass (Da):50,333
    Last modified:March 2, 2010 - v1
    Checksum:i1C59F7CBE3BCBA72
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001857 Genomic DNA. Translation: ADB58680.1.
    RefSeqiYP_003401353.1. NC_013741.1.

    Genome annotation databases

    EnsemblBacteriaiADB58680; ADB58680; Arcpr_1634.
    GeneIDi8740327.
    KEGGiapo:Arcpr_1634.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001857 Genomic DNA. Translation: ADB58680.1 .
    RefSeqi YP_003401353.1. NC_013741.1.

    3D structure databases

    ProteinModelPortali D2REY6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADB58680 ; ADB58680 ; Arcpr_1634 .
    GeneIDi 8740327.
    KEGGi apo:Arcpr_1634.

    Phylogenomic databases

    HOGENOMi HOG000230831.
    KOi K01601.
    OMAi FTQDWAS.

    Enzyme and pathway databases

    BioCyci APRO572546:GJI1-1685-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.110. 1 hit.
    3.30.70.150. 1 hit.
    HAMAPi MF_01133. RuBisCO_L_type3.
    InterProi IPR017712. RuBisCO_III.
    IPR000685. RuBisCO_lsu_C.
    IPR017443. RuBisCO_lsu_fd_N.
    IPR017444. RuBisCO_lsu_N.
    [Graphical view ]
    Pfami PF00016. RuBisCO_large. 1 hit.
    PF02788. RuBisCO_large_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51649. SSF51649. 1 hit.
    SSF54966. SSF54966. 1 hit.
    TIGRFAMsi TIGR03326. rubisco_III. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 5631 / JCM 9629 / NBRC 100127 / Av18Imported.

    Entry informationi

    Entry nameiD2REY6_ARCPA
    AccessioniPrimary (citable) accession number: D2REY6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 2, 2010
    Last sequence update: March 2, 2010
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Miscellaneous

    Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O2 to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3