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D2REY6

- D2REY6_ARCPA

UniProt

D2REY6 - D2REY6_ARCPA

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Protein

Ribulose bisphosphate carboxylase

Gene

rbcL

Organism
Archaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the addition of molecular CO2 and H2O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei166 – 1661Proton acceptorUniRule annotation
Binding sitei168 – 1681SubstrateUniRule annotation
Metal bindingi192 – 1921Magnesium; via carbamate groupUniRule annotation
Metal bindingi194 – 1941MagnesiumUniRule annotation
Metal bindingi195 – 1951MagnesiumUniRule annotation
Active sitei284 – 2841Proton acceptorUniRule annotation
Binding sitei285 – 2851SubstrateUniRule annotation
Binding sitei317 – 3171SubstrateUniRule annotation
Sitei325 – 3251Transition state stabilizerUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. oxidoreductase activity Source: UniProtKB-KW
  3. ribulose-bisphosphate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. AMP catabolic process Source: UniProtKB-HAMAP
  2. carbon fixation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported, OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciAPRO572546:GJI1-1685-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCOUniRule annotation
Gene namesi
Name:rbcLUniRule annotation
Ordered Locus Names:Arcpr_1634Imported
OrganismiArchaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18)Imported
Taxonomic identifieri572546 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
ProteomesiUP000001901: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei192 – 1921N6-carboxylysineUniRule annotation

Interactioni

Subunit structurei

Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD2REY6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni370 – 3723Substrate bindingUniRule annotation
Regioni392 – 3954Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the RuBisCO large chain family. Type III subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000230831.
KOiK01601.
OMAiFTQDWAS.

Family and domain databases

Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPiMF_01133. RuBisCO_L_type3.
InterProiIPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsiTIGR03326. rubisco_III. 1 hit.

Sequencei

Sequence statusi: Complete.

D2REY6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLHRTRVMPD FEMYFEYVDK SYEPSERDLI AVFRVKPSEG FKIEDVAGAI
60 70 80 90 100
ASESSTGTWT TLYDWCDKDR IKKLSAKAYE FIDLEDGSWI VKIAYPVELF
110 120 130 140 150
ERGSITCLLA SIAGNIFGMK RVAGLRLEDV YLPKEFLKYF EGPNFGKDVR
160 170 180 190 200
KIFKVYDRPI VGTVPKPKVG YTPDEVEKLA YELLSGGMDY IKDDENLTSQ
210 220 230 240 250
DFCKFEERAK AIMKAIDKAE SDTGEKKVWF ANITGDVKEM EKRMKIVADY
260 270 280 290 300
GNPYVMIDVV IAGWSVLKYM RELANDYGLA IHAHRAMHSA FTRNRYHGIS
310 320 330 340 350
MFVLAKLYRV IGVDQLHIGT AGYGKLEGGM WEVVQYAKIL RESSYVPDEK
360 370 380 390 400
DIFHIKQEFH HIKPAMPVSS GGLHPGNVAG VIDALGEDII IQVGGGVMGH
410 420 430 440
PDGPKAGAKA VRQALEAIKL GIPLDEYAKD HKELAKALEK WGYVKPV
Length:447
Mass (Da):50,333
Last modified:March 2, 2010 - v1
Checksum:i1C59F7CBE3BCBA72
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001857 Genomic DNA. Translation: ADB58680.1.
RefSeqiYP_003401353.1. NC_013741.1.

Genome annotation databases

EnsemblBacteriaiADB58680; ADB58680; Arcpr_1634.
GeneIDi8740327.
KEGGiapo:Arcpr_1634.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001857 Genomic DNA. Translation: ADB58680.1 .
RefSeqi YP_003401353.1. NC_013741.1.

3D structure databases

ProteinModelPortali D2REY6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADB58680 ; ADB58680 ; Arcpr_1634 .
GeneIDi 8740327.
KEGGi apo:Arcpr_1634.

Phylogenomic databases

HOGENOMi HOG000230831.
KOi K01601.
OMAi FTQDWAS.

Enzyme and pathway databases

BioCyci APRO572546:GJI1-1685-MONOMER.

Family and domain databases

Gene3Di 3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPi MF_01133. RuBisCO_L_type3.
InterProi IPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view ]
Pfami PF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsi TIGR03326. rubisco_III. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 5631 / JCM 9629 / NBRC 100127 / Av18Imported.

Entry informationi

Entry nameiD2REY6_ARCPA
AccessioniPrimary (citable) accession number: D2REY6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: October 29, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O2 to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3