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Protein

FAD synthase

Gene

ribL

Organism
Archaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.UniRule annotation

Catalytic activityi

ATP + FMN = diphosphate + FAD.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Pathwayi: FAD biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes FAD from FMN.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. FAD synthase (ribL)
This subpathway is part of the pathway FAD biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes FAD from FMN, the pathway FAD biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei92ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 10ATPUniRule annotation2
Nucleotide bindingi14 – 17ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandATP-binding, FAD, Flavoprotein, FMN, Nucleotide-binding

Enzyme and pathway databases

BioCyciAPRO572546:G1GH6-1577-MONOMER
UniPathwayiUPA00277; UER00407

Names & Taxonomyi

Protein namesi
Recommended name:
FAD synthaseUniRule annotation (EC:2.7.7.2UniRule annotation)
Alternative name(s):
FMN adenylyltransferaseUniRule annotation
Flavin adenine dinucleotide synthaseUniRule annotation
Gene namesi
Name:ribLUniRule annotation
Ordered Locus Names:Arcpr_1573
OrganismiArchaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18)
Taxonomic identifieri572546 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000001901 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004062331 – 155FAD synthaseAdd BLAST155

Proteomic databases

PRIDEiD2RES5

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi572546.Arcpr_1573

Structurei

3D structure databases

ProteinModelPortaliD2RES5
SMRiD2RES5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal FAD synthase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01222 Archaea
COG0615 LUCA
HOGENOMiHOG000284153
KOiK14656
OMAiVAHDETV
OrthoDBiPOG093Z0AQ4

Family and domain databases

Gene3Di3.40.50.620, 1 hit
HAMAPiMF_02115 FAD_synth_arch, 1 hit
InterProiView protein in InterPro
IPR004821 Cyt_trans-like
IPR024902 FAD_synth_RibL
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF01467 CTP_transf_like, 1 hit
TIGRFAMsiTIGR00125 cyt_tran_rel, 1 hit

Sequencei

Sequence statusi: Complete.

D2RES5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRVVATGTF DIIHPGHIRF LEEAKKLGDE LIVIVAREKN VRHKPKPIIP
60 70 80 90 100
EEQRVRVVSA LKPVDKAILG DEHDIFKPIM ELKPDIIALG YDQHFDEKKL
110 120 130 140 150
EEELRKRGLN TRVVRIKAKE ECEYCSSTKI IKRIVDVVKS RLQEYEEFFR

SRGML
Length:155
Mass (Da):18,086
Last modified:March 2, 2010 - v1
Checksum:i7DD14BED3745B94F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001857 Genomic DNA Translation: ADB58619.1
RefSeqiWP_012940955.1, NC_013741.1

Genome annotation databases

EnsemblBacteriaiADB58619; ADB58619; Arcpr_1573
GeneIDi8740264
KEGGiapo:Arcpr_1573

Similar proteinsi

Entry informationi

Entry nameiRIBL_ARCPA
AccessioniPrimary (citable) accession number: D2RES5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: March 2, 2010
Last modified: May 23, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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