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Protein

Fructose-1,6-bisphosphate aldolase/phosphatase

Gene

fbp

Organism
Archaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).UniRule annotation

Catalytic activityi

D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.UniRule annotation
D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei13Proton acceptor; for FBP phosphatase activityUniRule annotation1
Metal bindingi13Magnesium 1UniRule annotation1
Metal bindingi20Magnesium 1; via pros nitrogenUniRule annotation1
Binding sitei20FBP; via tele nitrogenUniRule annotation1
Metal bindingi54Magnesium 1UniRule annotation1
Metal bindingi54Magnesium 2UniRule annotation1
Metal bindingi55Magnesium 2UniRule annotation1
Binding sitei92FBPUniRule annotation1
Metal bindingi96Magnesium 1UniRule annotation1
Metal bindingi133Magnesium 2UniRule annotation1
Binding sitei134FBP/DHAPUniRule annotation1
Active sitei235Proton donor/acceptor; for FBP aldolase activityUniRule annotation1
Active sitei238Schiff-base intermediate with DHAP; for FBP aldolase activityUniRule annotation1
Metal bindingi238Magnesium 3; via carbonyl oxygenUniRule annotation1
Metal bindingi239Magnesium 3UniRule annotation1
Metal bindingi239Magnesium 4UniRule annotation1
Metal bindingi240Magnesium 2UniRule annotation1
Metal bindingi240Magnesium 3UniRule annotation1
Binding sitei272FBP/DHAP; via amide nitrogenUniRule annotation1
Binding sitei293FBP/DHAPUniRule annotation1
Binding sitei354FBPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation, LyaseUniRule annotation
Biological processCarbohydrate metabolismUniRule annotation, GluconeogenesisUniRule annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation, Schiff baseUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-1,6-bisphosphate aldolase/phosphataseUniRule annotation (EC:3.1.3.11UniRule annotation, EC:4.1.2.13UniRule annotation)
Short name:
FBP A/PUniRule annotation
Short name:
FBP aldolase/phosphataseUniRule annotation
Gene namesi
Name:fbpUniRule annotation
Ordered Locus Names:Arcpr_1256Imported
OrganismiArchaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18)Imported
Taxonomic identifieri572546 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000001901 Componenti: Chromosome

Interactioni

Subunit structurei

Homooctamer; dimer of tetramers.UniRule annotation

Protein-protein interaction databases

STRINGi572546.Arcpr_1256.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni105 – 106FBP bindingUniRule annotation2
Regioni248 – 249FBP binding; shared with dimeric partnerUniRule annotation2

Domaini

Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.UniRule annotation

Sequence similaritiesi

Belongs to the FBP aldolase/phosphatase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04180. Archaea.
COG1980. LUCA.
HOGENOMiHOG000229394.
KOiK01622.
OMAiHLVAGWM.
OrthoDBiPOG093Z0396.

Family and domain databases

HAMAPiMF_02067. FBP_aldolase_phosphatase. 1 hit.
InterProiView protein in InterPro
IPR002803. FBPase_V.
PfamiView protein in Pfam
PF01950. FBPase_3. 1 hit.
PIRSFiPIRSF015647. FBPtase_archl. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD014260. FBPase_V. 1 hit.
SUPFAMiSSF111249. SSF111249. 1 hit.

Sequencei

Sequence statusi: Complete.

D2RDW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEKITVSVI KADIGSVAGH STVPDEIKAL AEKKLNEAKE KGIIIDFRVF
60 70 80 90 100
NAGDDLELVM THRKGVDSEE IHGLAWETFK ACAEKAKELK LYAAGQDLLK
110 120 130 140 150
EAFSGNVRGL GPGVAEMEFT ERPAEPIIVF MMDKTEPGAF NLPIFRMFAD
160 170 180 190 200
PFNTAGLVID PSMHQGFRFE VWDIKEHKRV MLSTPEEMYD LLALIGSKGR
210 220 230 240 250
YVIKRVYPKE GGKLPADEPV AVVSTEKLFE IAGEYVGKDD PVAIVRAQSG
260 270 280 290 300
LPAVGEVLEA FAFPHLVSGW MRGSHNGPLM PVPFRYSKCT RFDGPPRVIA
310 320 330 340 350
AGFQLCNGKL IGPVDMFDDP AFDYTRQKAM EICDYIRRHG PFEPHRLPHE
360 370
EMEYTTLPKV LKKLEARFEK I
Length:371
Mass (Da):41,442
Last modified:March 2, 2010 - v1
Checksum:i7D9DCB5A70CBA9E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001857 Genomic DNA. Translation: ADB58308.1.
RefSeqiWP_012940644.1. NC_013741.1.

Genome annotation databases

EnsemblBacteriaiADB58308; ADB58308; Arcpr_1256.
GeneIDi8739942.
KEGGiapo:Arcpr_1256.

Similar proteinsi

Entry informationi

Entry nameiD2RDW4_ARCPA
AccessioniPrimary (citable) accession number: D2RDW4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: September 27, 2017
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported