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Protein

Ribose-5-phosphate isomerase A

Gene

rpiA

Organism
Gardnerella vaginalis (strain 409-05)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.UniRule annotationSAAS annotation

Catalytic activityi

D-ribose 5-phosphate = D-ribulose 5-phosphate.UniRule annotationSAAS annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage).UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ribose-5-phosphate isomerase A (rpiA)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei109Proton acceptorUniRule annotation1
Binding sitei127SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationImported

Enzyme and pathway databases

UniPathwayiUPA00115; UER00412.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-5-phosphate isomerase AUniRule annotationSAAS annotation (EC:5.3.1.6UniRule annotationSAAS annotation)
Alternative name(s):
Phosphoriboisomerase AUniRule annotation
Gene namesi
Name:rpiAUniRule annotationImported
Ordered Locus Names:HMPREF0424_0296Imported
OrganismiGardnerella vaginalis (strain 409-05)Imported
Taxonomic identifieri553190 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaBifidobacterialesBifidobacteriaceaeGardnerella
Proteomesi
  • UP000001888 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi553190.HMPREF0424_0296.

Structurei

3D structure databases

ProteinModelPortaliD2R9R6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni31 – 34Substrate bindingUniRule annotation4
Regioni87 – 90Substrate bindingUniRule annotation4
Regioni100 – 103Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the ribose 5-phosphate isomerase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105E66. Bacteria.
COG0120. LUCA.
HOGENOMiHOG000276369.
KOiK01807.
OMAiGACHVQE.

Family and domain databases

CDDicd01398. RPI_A. 1 hit.
HAMAPiMF_00170. Rib_5P_isom_A. 1 hit.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.

Sequencei

Sequence statusi: Complete.

D2R9R6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKAQQDALK KAAGIEAAKI VKNGMMVGLG TGSTVRFLVD ELGRRVKEEG
60 70 80 90 100
LSFTGVTTSR RTQEQAEGYG IKILDINEVD HIDVTIDGSD EVDKNFNGIK
110 120 130 140 150
GGGAALLWEK IVAINSDRIV WIVDASKVVD TIGKFPLPVE VIPFGSAQVI
160 170 180 190 200
RKFEKRGYKP VLRLDADGKE VRTDENNFVV DLHMERIEHP QELAKDLIET
210 220 230
VGVVEHGLFL NMVDTVIVGD PNGPRTLTNP NK
Length:232
Mass (Da):25,460
Last modified:March 2, 2010 - v1
Checksum:iF9EA50D1E094EAB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001849 Genomic DNA. Translation: ADB14073.1.
RefSeqiWP_004105437.1. NC_013721.1.

Genome annotation databases

EnsemblBacteriaiADB14073; ADB14073; HMPREF0424_0296.
KEGGigva:HMPREF0424_0296.
PATRICi32146582. VBIGarVag136958_0275.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001849 Genomic DNA. Translation: ADB14073.1.
RefSeqiWP_004105437.1. NC_013721.1.

3D structure databases

ProteinModelPortaliD2R9R6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi553190.HMPREF0424_0296.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADB14073; ADB14073; HMPREF0424_0296.
KEGGigva:HMPREF0424_0296.
PATRICi32146582. VBIGarVag136958_0275.

Phylogenomic databases

eggNOGiENOG4105E66. Bacteria.
COG0120. LUCA.
HOGENOMiHOG000276369.
KOiK01807.
OMAiGACHVQE.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00412.

Family and domain databases

CDDicd01398. RPI_A. 1 hit.
HAMAPiMF_00170. Rib_5P_isom_A. 1 hit.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiD2R9R6_GARV4
AccessioniPrimary (citable) accession number: D2R9R6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: November 2, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.