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Protein

Ribose-5-phosphate isomerase A

Gene

rpiA

Organism
Gardnerella vaginalis (strain 409-05)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.UniRule annotationSAAS annotation

Catalytic activityi

D-ribose 5-phosphate = D-ribulose 5-phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei109 – 1091Proton acceptorUniRule annotation
Binding sitei127 – 1271SubstrateUniRule annotation

GO - Molecular functioni

  1. ribose-5-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt, non-oxidative branch Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciGVAG553190:GJPT-300-MONOMER.
UniPathwayiUPA00115; UER00412.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-5-phosphate isomerase AUniRule annotationSAAS annotation (EC:5.3.1.6UniRule annotationSAAS annotation)
Alternative name(s):
Phosphoriboisomerase AUniRule annotation
Gene namesi
Name:rpiAUniRule annotationImported
Ordered Locus Names:HMPREF0424_0296Imported
OrganismiGardnerella vaginalis (strain 409-05)Imported
Taxonomic identifieri553190 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeGardnerella
ProteomesiUP000001888 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliD2R9R6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni31 – 344Substrate bindingUniRule annotation
Regioni87 – 904Substrate bindingUniRule annotation
Regioni100 – 1034Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the ribose 5-phosphate isomerase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000276369.
KOiK01807.
OMAiGACHVQE.
OrthoDBiEOG67MF61.

Family and domain databases

HAMAPiMF_00170. Rib_5P_isom_A.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.

Sequencei

Sequence statusi: Complete.

D2R9R6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKAQQDALK KAAGIEAAKI VKNGMMVGLG TGSTVRFLVD ELGRRVKEEG
60 70 80 90 100
LSFTGVTTSR RTQEQAEGYG IKILDINEVD HIDVTIDGSD EVDKNFNGIK
110 120 130 140 150
GGGAALLWEK IVAINSDRIV WIVDASKVVD TIGKFPLPVE VIPFGSAQVI
160 170 180 190 200
RKFEKRGYKP VLRLDADGKE VRTDENNFVV DLHMERIEHP QELAKDLIET
210 220 230
VGVVEHGLFL NMVDTVIVGD PNGPRTLTNP NK
Length:232
Mass (Da):25,460
Last modified:March 2, 2010 - v1
Checksum:iF9EA50D1E094EAB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001849 Genomic DNA. Translation: ADB14073.1.
RefSeqiYP_003373551.1. NC_013721.1.

Genome annotation databases

EnsemblBacteriaiADB14073; ADB14073; HMPREF0424_0296.
KEGGigva:HMPREF0424_0296.
PATRICi32146582. VBIGarVag136958_0275.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001849 Genomic DNA. Translation: ADB14073.1.
RefSeqiYP_003373551.1. NC_013721.1.

3D structure databases

ProteinModelPortaliD2R9R6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADB14073; ADB14073; HMPREF0424_0296.
KEGGigva:HMPREF0424_0296.
PATRICi32146582. VBIGarVag136958_0275.

Phylogenomic databases

HOGENOMiHOG000276369.
KOiK01807.
OMAiGACHVQE.
OrthoDBiEOG67MF61.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00412.
BioCyciGVAG553190:GJPT-300-MONOMER.

Family and domain databases

HAMAPiMF_00170. Rib_5P_isom_A.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Comparative genomics of Gardnerella vaginalis strains reveals substantial differences in metabolic and virulence potential."
    Yeoman C.J., Yildirim S., Thomas S.M., Durkin A.S., Torralba M., Sutton G., Buhay C.J., Ding Y., Dugan-Rocha S.P., Muzny D.M., Qin X., Gibbs R.A., Leigh S.R., Stumpf R., White B.A., Highlander S.K., Nelson K.E., Wilson B.A.
    PLoS ONE 5:E12411-E12411(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 409-05Imported.

Entry informationi

Entry nameiD2R9R6_GARV4
AccessioniPrimary (citable) accession number: D2R9R6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: April 1, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.