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D2R9R6

- D2R9R6_GARV4

UniProt

D2R9R6 - D2R9R6_GARV4

Protein

Ribose-5-phosphate isomerase A

Gene

rpiA

Organism
Gardnerella vaginalis (strain 409-05)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (02 Mar 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.UniRule annotationSAAS annotation

    Catalytic activityi

    D-ribose 5-phosphate = D-ribulose 5-phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei109 – 1091Proton acceptorUniRule annotation
    Binding sitei127 – 1271SubstrateUniRule annotation

    GO - Molecular functioni

    1. ribose-5-phosphate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pentose-phosphate shunt, non-oxidative branch Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Enzyme and pathway databases

    BioCyciGVAG553190:GJPT-300-MONOMER.
    UniPathwayiUPA00115; UER00412.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribose-5-phosphate isomerase AUniRule annotation (EC:5.3.1.6UniRule annotation)
    Alternative name(s):
    Phosphoriboisomerase AUniRule annotation
    Gene namesi
    Name:rpiAUniRule annotationImported
    Ordered Locus Names:HMPREF0424_0296Imported
    OrganismiGardnerella vaginalis (strain 409-05)Imported
    Taxonomic identifieri553190 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeGardnerella
    ProteomesiUP000001888: Chromosome

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotationSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD2R9R6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni31 – 344Substrate bindingUniRule annotation
    Regioni87 – 904Substrate bindingUniRule annotation
    Regioni100 – 1034Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the ribose 5-phosphate isomerase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000276369.
    KOiK01807.
    OMAiINDITYI.
    OrthoDBiEOG67MF61.

    Family and domain databases

    HAMAPiMF_00170. Rib_5P_isom_A.
    InterProiIPR004788. Ribose5P_isomerase_typA.
    IPR020672. Ribose5P_isomerase_typA_subgr.
    [Graphical view]
    PANTHERiPTHR11934. PTHR11934. 1 hit.
    PfamiPF06026. Rib_5-P_isom_A. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00021. rpiA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D2R9R6-1 [UniParc]FASTAAdd to Basket

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    MDKAQQDALK KAAGIEAAKI VKNGMMVGLG TGSTVRFLVD ELGRRVKEEG    50
    LSFTGVTTSR RTQEQAEGYG IKILDINEVD HIDVTIDGSD EVDKNFNGIK 100
    GGGAALLWEK IVAINSDRIV WIVDASKVVD TIGKFPLPVE VIPFGSAQVI 150
    RKFEKRGYKP VLRLDADGKE VRTDENNFVV DLHMERIEHP QELAKDLIET 200
    VGVVEHGLFL NMVDTVIVGD PNGPRTLTNP NK 232
    Length:232
    Mass (Da):25,460
    Last modified:March 2, 2010 - v1
    Checksum:iF9EA50D1E094EAB5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001849 Genomic DNA. Translation: ADB14073.1.
    RefSeqiYP_003373551.1. NC_013721.1.

    Genome annotation databases

    EnsemblBacteriaiADB14073; ADB14073; HMPREF0424_0296.
    GeneIDi8709034.
    KEGGigva:HMPREF0424_0296.
    PATRICi32146582. VBIGarVag136958_0275.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001849 Genomic DNA. Translation: ADB14073.1 .
    RefSeqi YP_003373551.1. NC_013721.1.

    3D structure databases

    ProteinModelPortali D2R9R6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADB14073 ; ADB14073 ; HMPREF0424_0296 .
    GeneIDi 8709034.
    KEGGi gva:HMPREF0424_0296.
    PATRICi 32146582. VBIGarVag136958_0275.

    Phylogenomic databases

    HOGENOMi HOG000276369.
    KOi K01807.
    OMAi INDITYI.
    OrthoDBi EOG67MF61.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00412 .
    BioCyci GVAG553190:GJPT-300-MONOMER.

    Family and domain databases

    HAMAPi MF_00170. Rib_5P_isom_A.
    InterProi IPR004788. Ribose5P_isomerase_typA.
    IPR020672. Ribose5P_isomerase_typA_subgr.
    [Graphical view ]
    PANTHERi PTHR11934. PTHR11934. 1 hit.
    Pfami PF06026. Rib_5-P_isom_A. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00021. rpiA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics of Gardnerella vaginalis strains reveals substantial differences in metabolic and virulence potential."
      Yeoman C.J., Yildirim S., Thomas S.M., Durkin A.S., Torralba M., Sutton G., Buhay C.J., Ding Y., Dugan-Rocha S.P., Muzny D.M., Qin X., Gibbs R.A., Leigh S.R., Stumpf R., White B.A., Highlander S.K., Nelson K.E., Wilson B.A.
      PLoS ONE 5:E12411-E12411(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 409-05Imported.

    Entry informationi

    Entry nameiD2R9R6_GARV4
    AccessioniPrimary (citable) accession number: D2R9R6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 2, 2010
    Last sequence update: March 2, 2010
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3