ID   D2R7U9_PIRSD            Unreviewed;       417 AA.
AC   D2R7U9;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 63.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
DE   Flags: Precursor;
GN   OrderedLocusNames=Psta_4638 {ECO:0000313|EMBL:ADB19280.1};
OS   Pirellula staleyi (strain ATCC 27377 / DSM 6068 / ICPB 4128) (Pirella
OS   staleyi).
OC   Bacteria; Planctomycetota; Planctomycetia; Pirellulales; Pirellulaceae;
OC   Pirellula.
OX   NCBI_TaxID=530564 {ECO:0000313|EMBL:ADB19280.1, ECO:0000313|Proteomes:UP000001887};
RN   [1] {ECO:0000313|EMBL:ADB19280.1, ECO:0000313|Proteomes:UP000001887}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27377 / DSM 6068 / ICPB 4128
RC   {ECO:0000313|Proteomes:UP000001887};
RX   PubMed=21304671; DOI=10.4056/sigs.51657;
RA   Clum A., Tindall B.J., Sikorski J., Ivanova N., Mavrommatis K., Lucas S.,
RA   Glavina del Rio T., Nolan M., Chen F., Tice H., Pitluck S., Cheng J.F.,
RA   Chertkov O., Brettin T., Han C., Detter J.C., Kuske C., Bruce D.,
RA   Goodwin L., Ovchinikova G., Pati A., Mikhailova N., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D., Chain P.,
RA   Rohde M., Goker M., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P., Lapidus A.;
RT   "Complete genome sequence of Pirellula staleyi type strain (ATCC 27377).";
RL   Stand. Genomic Sci. 1:308-316(2009).
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DR   EMBL; CP001848; ADB19280.1; -; Genomic_DNA.
DR   RefSeq; WP_012913539.1; NC_013720.1.
DR   AlphaFoldDB; D2R7U9; -.
DR   STRING; 530564.Psta_4638; -.
DR   CAZy; GH33; Glycoside Hydrolase Family 33.
DR   KEGG; psl:Psta_4638; -.
DR   eggNOG; COG4409; Bacteria.
DR   HOGENOM; CLU_024620_1_0_0; -.
DR   OrthoDB; 7294637at2; -.
DR   Proteomes; UP000001887; Chromosome.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   4: Predicted;
KW   Glycosidase {ECO:0000313|EMBL:ADB19280.1};
KW   Hydrolase {ECO:0000313|EMBL:ADB19280.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001887};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          66..381
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
SQ   SEQUENCE   417 AA;  45310 MW;  5C8164805E51E5F6 CRC64;
     MSRHSSLQKL IFNSLCLTIL AVTIAPLGAT GEEPLTQVDV FEAGVGGYAM YRIPGVVVTP
     KGTILAYCEA RRTGKSDWDE INILMRRSID GGKTFLEPQH VAHQGDKVPK NPLAIKQKLG
     LQPEATVNNP VAVVDRKSGR ITMLYCVEYS RCFAMHSDDE GATFSKPRDI TAALEKLRQE
     YPWFVVAIGP GHAIQLKNGR LVAAVWLSTG EGGHAHRPSV TTTLVSDDGG ETWSAGEIAA
     RPTDTIVNPN ETTLAELSDG TVMLNIRSES KPNRRLITLS KNGSTGWSEP KFDEALVEPI
     CMASLLAVPT REQQLLIYAG PDNLTSAKTK EPKPGTGRDR KNLTVQLSRD DGQTWTAKRV
     LEPGPSAYSD LAVGPDGRVH CFFERCKAEG TGSPYARLSL VSFKPDWITQ PATATSK
//