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D2QQG4

- D2QQG4_SPILD

UniProt

D2QQG4 - D2QQG4_SPILD

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Protein

Isocitrate dehydrogenase [NADP]

Gene
Slin_4767
Organism
Spirosoma linguale (strain ATCC 33905 / DSM 74 / LMG 10896)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771Substrate By similarityUniRule annotation
Binding sitei82 – 821NADP By similarityUniRule annotation
Binding sitei109 – 1091Substrate By similarityUniRule annotation
Binding sitei132 – 1321Substrate By similarityUniRule annotation
Sitei139 – 1391Critical for catalysis By similarityUniRule annotation
Sitei210 – 2101Critical for catalysis By similarityUniRule annotation
Metal bindingi245 – 2451Magnesium or manganese By similarity
Binding sitei253 – 2531NADP By similarityUniRule annotation
Metal bindingi268 – 2681Magnesium or manganese By similarity
Binding sitei321 – 3211NADP; via amide nitrogen and carbonyl oxygen By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADP By similarityUniRule annotation
Nucleotide bindingi303 – 3086NADP By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciSLIN504472:GHKB-4803-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Slin_4767Imported
OrganismiSpirosoma linguale (strain ATCC 33905 / DSM 74 / LMG 10896)Imported
Taxonomic identifieri504472 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeSpirosoma
ProteomesiUP000002028: Chromosome

Structurei

3D structure databases

ProteinModelPortaliD2QQG4.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000019858.
KOiK00031.
OMAiTRIIWDK.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D2QQG4-1 [UniParc]FASTAAdd to Basket

« Hide

MEKIKVANPV VELDGDEMTR IIWKFIKDKL ILPYLDLDIK YYDLGIEYRD    50
ETNDQVTIDA ANAIKEYGVG IKCATITPDE DRVKEFNLKQ MWKSPNGTIR 100
NILDGTVFRE PIVMNNVPRL VTNWKAPIIV GRHAFGDQYR ATDFLVPGKG 150
KLTMKFEGED GTVLEYDVFN FPGAGVAMGM YNLDESIRGF ARACFNMALQ 200
KNWPLYLSTK NTILKKYDGR FKDIFQEIYD AEFAGKVHYE HRLIDDMVAS 250
ALKWEGNFVW ACKNYDGDVQ SDTVAQGFGS LGLMTSVLVT PDGKTMEAEA 300
AHGTVTRHYR EYQKGNKTST NPIASIYAWT RGLAFRGQLD GNQPLIDFAN 350
ALEAVCVETV ESGKMTKDLA LSAYPVGTKL TAGEHYLNTE DFLEALDTNL 400
QAKLA 405
Length:405
Mass (Da):45,537
Last modified:March 2, 2010 - v1
Checksum:iD6A889B983932A49
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001769 Genomic DNA. Translation: ADB40745.1.
RefSeqiWP_012929248.1. NC_013730.1.
YP_003389544.1. NC_013730.1.

Genome annotation databases

EnsemblBacteriaiADB40745; ADB40745; Slin_4767.
GeneIDi8728531.
KEGGisli:Slin_4767.
PATRICi32439483. VBISpiLin97822_4764.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001769 Genomic DNA. Translation: ADB40745.1 .
RefSeqi WP_012929248.1. NC_013730.1.
YP_003389544.1. NC_013730.1.

3D structure databases

ProteinModelPortali D2QQG4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADB40745 ; ADB40745 ; Slin_4767 .
GeneIDi 8728531.
KEGGi sli:Slin_4767.
PATRICi 32439483. VBISpiLin97822_4764.

Phylogenomic databases

HOGENOMi HOG000019858.
KOi K00031.
OMAi TRIIWDK.

Enzyme and pathway databases

BioCyci SLIN504472:GHKB-4803-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33905 / DSM 74 / LMG 10896.

Entry informationi

Entry nameiD2QQG4_SPILD
AccessioniPrimary (citable) accession number: D2QQG4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: September 3, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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