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D2QQG4 (D2QQG4_SPILD) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108

EC=1.1.1.42 PIRNR PIRNR000108
Gene names
Ordered Locus Names:Slin_4767 EMBL ADB40745.1
OrganismSpirosoma linguale (strain ATCC 33905 / DSM 74 / LMG 10896) [Complete proteome] [HAMAP] EMBL ADB40745.1
Taxonomic identifier504472 [NCBI]
Taxonomic lineageBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeSpirosoma

Protein attributes

Sequence length405 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding303 – 3086NADP By similarity PIRSR PIRSR000108-4
Region94 – 1007Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2451Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2681Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity PIRSR PIRSR000108-2
Binding site821NADP By similarity PIRSR PIRSR000108-4
Binding site1091Substrate By similarity PIRSR PIRSR000108-2
Binding site1321Substrate By similarity PIRSR PIRSR000108-2
Binding site2531NADP By similarity PIRSR PIRSR000108-4
Binding site3211NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2101Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
D2QQG4 [UniParc].

Last modified March 2, 2010. Version 1.
Checksum: D6A889B983932A49

FASTA40545,537
        10         20         30         40         50         60 
MEKIKVANPV VELDGDEMTR IIWKFIKDKL ILPYLDLDIK YYDLGIEYRD ETNDQVTIDA 

        70         80         90        100        110        120 
ANAIKEYGVG IKCATITPDE DRVKEFNLKQ MWKSPNGTIR NILDGTVFRE PIVMNNVPRL 

       130        140        150        160        170        180 
VTNWKAPIIV GRHAFGDQYR ATDFLVPGKG KLTMKFEGED GTVLEYDVFN FPGAGVAMGM 

       190        200        210        220        230        240 
YNLDESIRGF ARACFNMALQ KNWPLYLSTK NTILKKYDGR FKDIFQEIYD AEFAGKVHYE 

       250        260        270        280        290        300 
HRLIDDMVAS ALKWEGNFVW ACKNYDGDVQ SDTVAQGFGS LGLMTSVLVT PDGKTMEAEA 

       310        320        330        340        350        360 
AHGTVTRHYR EYQKGNKTST NPIASIYAWT RGLAFRGQLD GNQPLIDFAN ALEAVCVETV 

       370        380        390        400 
ESGKMTKDLA LSAYPVGTKL TAGEHYLNTE DFLEALDTNL QAKLA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001769 Genomic DNA. Translation: ADB40745.1.
RefSeqYP_003389544.1. NC_013730.1.

3D structure databases

ProteinModelPortalD2QQG4.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADB40745; ADB40745; Slin_4767.
GeneID8728531.
KEGGsli:Slin_4767.
PATRIC32439483. VBISpiLin97822_4764.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000019858.
KOK00031.
OMAQHQQGKP.

Enzyme and pathway databases

BioCycSLIN504472:GHKB-4803-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD2QQG4_SPILD
AccessionPrimary (citable) accession number: D2QQG4
Entry history
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: February 19, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)