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Protein

Isocitrate dehydrogenase [NADP]

Gene

Slin_4767

Organism
Spirosoma linguale (strain ATCC 33905 / DSM 74 / LMG 10896)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771SubstrateUniRule annotation
Binding sitei82 – 821NADPUniRule annotation
Binding sitei109 – 1091SubstrateUniRule annotation
Binding sitei132 – 1321SubstrateUniRule annotation
Sitei139 – 1391Critical for catalysisUniRule annotation
Sitei210 – 2101Critical for catalysisUniRule annotation
Metal bindingi245 – 2451Magnesium or manganeseUniRule annotation
Binding sitei253 – 2531NADPUniRule annotation
Metal bindingi268 – 2681Magnesium or manganeseUniRule annotation
Binding sitei321 – 3211NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADPUniRule annotation
Nucleotide bindingi303 – 3086NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciSLIN504472:GHKB-4803-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Slin_4767Imported
OrganismiSpirosoma linguale (strain ATCC 33905 / DSM 74 / LMG 10896)Imported
Taxonomic identifieri504472 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeSpirosoma
ProteomesiUP000002028: Chromosome

Structurei

3D structure databases

ProteinModelPortaliD2QQG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000019858.
KOiK00031.
OMAiQVIEHDV.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D2QQG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKIKVANPV VELDGDEMTR IIWKFIKDKL ILPYLDLDIK YYDLGIEYRD
60 70 80 90 100
ETNDQVTIDA ANAIKEYGVG IKCATITPDE DRVKEFNLKQ MWKSPNGTIR
110 120 130 140 150
NILDGTVFRE PIVMNNVPRL VTNWKAPIIV GRHAFGDQYR ATDFLVPGKG
160 170 180 190 200
KLTMKFEGED GTVLEYDVFN FPGAGVAMGM YNLDESIRGF ARACFNMALQ
210 220 230 240 250
KNWPLYLSTK NTILKKYDGR FKDIFQEIYD AEFAGKVHYE HRLIDDMVAS
260 270 280 290 300
ALKWEGNFVW ACKNYDGDVQ SDTVAQGFGS LGLMTSVLVT PDGKTMEAEA
310 320 330 340 350
AHGTVTRHYR EYQKGNKTST NPIASIYAWT RGLAFRGQLD GNQPLIDFAN
360 370 380 390 400
ALEAVCVETV ESGKMTKDLA LSAYPVGTKL TAGEHYLNTE DFLEALDTNL

QAKLA
Length:405
Mass (Da):45,537
Last modified:March 2, 2010 - v1
Checksum:iD6A889B983932A49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001769 Genomic DNA. Translation: ADB40745.1.
RefSeqiYP_003389544.1. NC_013730.1.

Genome annotation databases

EnsemblBacteriaiADB40745; ADB40745; Slin_4767.
GeneIDi8728531.
KEGGisli:Slin_4767.
PATRICi32439483. VBISpiLin97822_4764.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001769 Genomic DNA. Translation: ADB40745.1.
RefSeqiYP_003389544.1. NC_013730.1.

3D structure databases

ProteinModelPortaliD2QQG4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADB40745; ADB40745; Slin_4767.
GeneIDi8728531.
KEGGisli:Slin_4767.
PATRICi32439483. VBISpiLin97822_4764.

Phylogenomic databases

HOGENOMiHOG000019858.
KOiK00031.
OMAiQVIEHDV.

Enzyme and pathway databases

BioCyciSLIN504472:GHKB-4803-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33905 / DSM 74 / LMG 10896Imported.

Entry informationi

Entry nameiD2QQG4_SPILD
AccessioniPrimary (citable) accession number: D2QQG4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: March 4, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.