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Protein

D-alanine--D-alanine ligase

Gene

Slin_1108

Organism
Spirosoma linguale (strain ATCC 33905 / DSM 74 / LMG 10896)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cell wall formation.SAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

Cofactori

Mg2+SAAS annotation, Mn2+SAAS annotationNote: Binds 2 magnesium or manganese ions per subunit.SAAS annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
  3. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotationImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSLIN504472:GHKB-1113-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseSAAS annotation (EC:6.3.2.4SAAS annotation)
Gene namesi
Ordered Locus Names:Slin_1108Imported
OrganismiSpirosoma linguale (strain ATCC 33905 / DSM 74 / LMG 10896)Imported
Taxonomic identifieri504472 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeSpirosoma
ProteomesiUP000002028 Componenti: Chromosome

Subcellular locationi

Cytoplasm SAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

Family & Domainsi

Sequence similaritiesi

Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000011592.
KOiK01921.
OMAiFKQMAEI.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 2 hits.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D2QK37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIGIFFGGP AREREVSFAG GRTALANLDK GLFEPVLVFV DGRGRFRLVS
60 70 80 90 100
PDFLQSPSLH DALPQDSSGF SVYDESLAVD TLDAILPELR PEQFRDHFDL
110 120 130 140 150
AFLAMHGPDC EDGAIQGLLE WHKMPYTGPG LVGSAVGINK ILQNELIALA
160 170 180 190 200
NGQKKKTATI SRDDYEQADK AQFFQSLVEH LGLPIVIKAP HQGSSIGVAI
210 220 230 240 250
VREADLAQFC RSVEQCFFTM SIQPDGWSKL SGWTSLSGTE KHELAQKMVS
260 270 280 290 300
LDSGISFPVV IEQTGEVIKH PADFVARLDA LMAQSSQPIT LASLNAEDEV
310 320 330 340 350
LFEEFITGQE FSCGVIQDDD QVAIALPPTE IYNVTSFDFE SKYKLNTTKK
360 370 380 390 400
RIPVETSLEN NRKIQLAVAQ VFTRLGINVY SRIDGFLTPA GDVLLHDPNT
410 420 430 440 450
IPGMSPSSLI FKQMAEIGLN LANSLTYLIR QSLRERIRTG KDTFHLKHLL
460 470 480 490 500
AELDAQLAHR KANPLPERVV SFGSGDEEFI AAKQQYNELA ASGTVRPSLM
510 520 530 540 550
YIKSKQESHE IPVNLLFKDT IAELETALSQ PRHPLLLETA ELARHITERY

V
Length:551
Mass (Da):60,944
Last modified:March 2, 2010 - v1
Checksum:iB63B528D14BC5272
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001769 Genomic DNA. Translation: ADB37159.1.
RefSeqiWP_012925710.1. NC_013730.1.
YP_003385958.1. NC_013730.1.

Genome annotation databases

EnsemblBacteriaiADB37159; ADB37159; Slin_1108.
KEGGisli:Slin_1108.
PATRICi32432109. VBISpiLin97822_1105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001769 Genomic DNA. Translation: ADB37159.1.
RefSeqiWP_012925710.1. NC_013730.1.
YP_003385958.1. NC_013730.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADB37159; ADB37159; Slin_1108.
KEGGisli:Slin_1108.
PATRICi32432109. VBISpiLin97822_1105.

Phylogenomic databases

HOGENOMiHOG000011592.
KOiK01921.
OMAiFKQMAEI.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciSLIN504472:GHKB-1113-MONOMER.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 2 hits.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33905 / DSM 74 / LMG 10896Imported.

Entry informationi

Entry nameiD2QK37_SPILD
AccessioniPrimary (citable) accession number: D2QK37
Entry historyi
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: April 1, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.