D2QGW2 (D2QGW2_SPILD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Thymidine kinase RuleBase RU000544 HAMAP-Rule MF_00124
EC=2.7.1.21 RuleBase RU000544 HAMAP-Rule MF_00124

Gene names

Name:	tdk HAMAP-Rule MF_00124
Ordered Locus Names:	Slin_5162 EMBL ADB41134.1

Organism

Spirosoma linguale (strain ATCC 33905 / DSM 74 / LMG 10896) [Complete proteome] [HAMAP] EMBL ADB41134.1

Taxonomic identifier

504472 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Bacteroidetes/Chlorobi group › Bacteroidetes › Cytophagia › Cytophagales › Cytophagaceae › Spirosoma › Spirosoma linguale

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate. RuleBase RU000544 HAMAP-Rule MF_00124
Subunit structure	Homotetramer By similarity. HAMAP-Rule MF_00124 SAAS SAAS001267
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00124 SAAS SAAS001267.
Sequence similarities	Belongs to the thymidine kinase family. HAMAP-Rule MF_00124 RuleBase RU004165

Ontologies

Keywords
Biological process	DNA synthesis RuleBase RU000544 HAMAP-Rule MF_00124 SAAS SAAS020634
Cellular component	Cytoplasm HAMAP-Rule MF_00124 SAAS SAAS001267
Ligand	ATP-binding RuleBase RU000544 HAMAP-Rule MF_00124 SAAS SAAS020634 Metal-binding HAMAP-Rule MF_00124 SAAS SAAS001267 Nucleotide-binding Zinc HAMAP-Rule MF_00124 SAAS SAAS001267
Molecular function	Kinase RuleBase RU000544 HAMAP-Rule MF_00124 SAAS SAAS020634 EMBL ADB41134.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP thymidine kinase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	24 – 31	8	ATP By similarity HAMAP-Rule MF_00124
	Nucleotide binding	96 – 99	4	ATP By similarity HAMAP-Rule MF_00124
Sites
	Active site	97	1	Proton acceptor By similarity HAMAP-Rule MF_00124
	Metal binding	153	1	Zinc By similarity HAMAP-Rule MF_00124
	Metal binding	156	1	Zinc By similarity HAMAP-Rule MF_00124
	Metal binding	185	1	Zinc By similarity HAMAP-Rule MF_00124
	Metal binding	188	1	Zinc By similarity HAMAP-Rule MF_00124

Sequences

	Sequence		Length	Mass (Da)
	D2QGW2 [UniParc]. Last modified March 2, 2010. Version 1. Checksum: CF80F7AD460FF793	FASTA	209	23,311
	10 20 30 40 50 60 MFIEPSRRRE PPHLRTGWIE VICGSMFSGK TEELIRRLTR AQIAKLNVKI VKPALDTRYH 70 80 90 100 110 120 DENIVSHSSI TISSVPVQTA GQILALAGNC DVVGIDEAQF FDQDITNVCT QLANQGKRVI 130 140 150 160 170 180 VAGLDMDFAG KPFGCMPQLL SIAEYVTKVH AICVVCGDIA QYSYRLVPSK ERVLLGETDS 190 200 YEARCRRCFN LGNDAGRKEW AYEDIANDE

References

[1]

"The complete chromosome of Spirosoma linguale DSM 74." US DOE Joint Genome Institute (JGI-PGF) Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Mikhailova N., Ovchinnikova G., Saunders E., Brettin T., Detter J.C., Han C., Larimer F. , Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Tindal B., Schutze A., Schneider S., Goker M., Klenk H.-P., Eisen J.A. Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33905 / DSM 74 / LMG 10896.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001769 Genomic DNA. Translation: ADB41134.1.
RefSeq	YP_003389933.1. NC_013730.1.
3D structure databases
ProteinModelPortal	D2QGW2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADB41134; ADB41134; Slin_5162.
GeneID	8728928.
KEGG	sli:Slin_5162.
PATRIC	32440253. VBISpiLin97822_5147.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000076390.
KO	K00857.
OMA	KVHAICV.
Enzyme and pathway databases
BioCyc	SLIN504472:GHKB-5200-MONOMER.
Family and domain databases
HAMAP	MF_00124. Thymidine_kinase.
InterPro	IPR027417. P-loop_NTPase. IPR001267. Thymidine_kinase. IPR020633. Thymidine_kinase_CS. IPR020634. Thymidine_kinase_subgr. [Graphical view]
PANTHER	PTHR11441. PTHR11441. 1 hit.
Pfam	PF00265. TK. 1 hit. [Graphical view]
PIRSF	PIRSF035805. TK_cell. 1 hit.
SUPFAM	SSF52540. SSF52540. 1 hit.
PROSITE	PS00603. TK_CELLULAR_TYPE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

D2QGW2_SPILD

Accession

Primary (citable) accession number: D2QGW2

Entry history

Integrated into UniProtKB/TrEMBL:	March 2, 2010
Last sequence update:	March 2, 2010
Last modified:	May 29, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)