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D2Q550 (D2Q550_KRIFD) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Kfla_7073 EMBL ADB36061.1
OrganismKribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399) [Complete proteome] [HAMAP] EMBL ADB36061.1
Taxonomic identifier479435 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaeNocardioidaceaeKribbella

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain103 – 310208ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding137 – 19256ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2641Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2771Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2771Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2791Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
D2Q550 [UniParc].

Last modified March 2, 2010. Version 1.
Checksum: 4821840777973289

FASTA31532,840
        10         20         30         40         50         60 
MSDLGRVLVL AGGLSHERDV SLRSGRRVAD ALRSVGVEVE QRDVDASLVE RLRNDPPDAV 

        70         80         90        100        110        120 
FPVLHGVTGE DGALRQVLDL YGVPYVGADA AACRTAFDKP VASTMVRSAG LRSPESVVLG 

       130        140        150        160        170        180 
HDTFRELGAA ALMEAVVGQL GLPLVVKPAR GGSALGASIV RTIDELPSAM VNCYAYGPVA 

       190        200        210        220        230        240 
LIERYVEGTE VAVTVVDTGD GPWALPAVEI QPDSGFYDYE ARYTAGATQF VVPARLDAAV 

       250        260        270        280        290        300 
AAACAQAAVT AHRALGLRDL SRSDLVVDAQ GVPWFLEVNV APGMTETSLV PLAAEAAGIE 

       310 
LGVLCRDLLA TAAAR 

« Hide

References

[1]"The complete genome of Kribbella flavida DSM 17836."
US DOE Joint Genome Institute (JGI-PGF)
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M. expand/collapse author list , Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Pukall R., Klenk H.-P., Eisen J.A.
Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 17836 / JCM 10339 / NBRC 14399.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001736 Genomic DNA. Translation: ADB36061.1.
RefSeqYP_003384860.1. NC_013729.1.

3D structure databases

ProteinModelPortalD2Q550.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADB36061; ADB36061; Kfla_7073.
GeneID8723714.
KEGGkfl:Kfla_7073.
PATRIC32244676. VBIKriFla67707_7073.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011592.
KOK01921.
OMATPDWVAL.

Enzyme and pathway databases

BioCycKFLA479435:GI0F-7137-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD2Q550_KRIFD
AccessionPrimary (citable) accession number: D2Q550
Entry history
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: February 19, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)