2-oxoglutarate dehydrogenase, E1 subunit

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• oxoglutarate dehydrogenase (succinyl-transferring) activity Source: InterPro
• thiamine pyrophosphate binding Source: InterPro
• transferase activity, transferring acyl groups Source: InterPro

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• tricarboxylic acid cycle Source: InterPro

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Coiled coil

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MATEPSDTNP LAAFGSNEWL VDEMYEKYQQ DPKSVDPAWQ TYFESDGFKG 
        60         70         80         90        100
SGPGDAKPVT TGPADAPRPD AVSDNKTPEA AVRGTTATAP AASKPAAQAA 
       110        120        130        140        150
ARTPEQAAPP TTASTAQPAQ SRPAQTQPPA SAQQTAPAAS GAPTGGTVNQ 
       160        170        180        190        200
PPSAQPKPAP ATSTDAERKV LRGAPARTAQ NMETSLQVPT ATSVRQVPVK 
       210        220        230        240        250
LLIDNRIVIN NHLKRARGGK ISFTHLIGWA LVKALKTLPE MNASYDETEG 
       260        270        280        290        300
KPTLVQPAHI NLGLAIDMAK PDGTRQLLVP SIKAAETMTF AEFWMAYEDI 
       310        320        330        340        350
VRRARDNKLA LPDFQGTTIS LTNPGTIGTQ HSVPRLMSGQ GCIIGVGAME 
       360        370        380        390        400
YPPEYQGAAE ETMAKLAVSK VMTLTSTYDH RIIQGAQSGE FLRKIHQLLL 
       410        420        430        440        450
GEEGFYDEIF QSLRIPYEPI RWAADLPHSH EEDISKQARI LELIHAYRVR 
       460        470        480        490        500
GHIMADTDPL EYKQRSHPDL DVATHGLTLW DLDREFATGS FGAATDRRFM 
       510        520        530        540        550
KLREILGILR DSYCRTTGVE YMHIQDPEQR KWLQERIERP HTKPPREEQL 
       560        570        580        590        600
RILAKLNEAE AFETFLQTKY VGQKRFSLEG GETTIPLLDE LCEEAAGAGL 
       610        620        630        640        650
DEVVIGMAHR GRLNVLANIV GKSYGQIFRE FDGNIDPRTV QGSGDVKYHL 
       660        670        680        690        700
GAEGEFVSEF GDKIKVSVAA NPSHLETVDP VLEGIVRAKQ DILDRGAAFP 
       710        720        730        740        750
VLPVLVHGDA AFAGQGVVAE TLNLSQLRGY RTGGTIHVIV NNQVGFTTSP 
       760        770        780        790        800
ASSRSSMYCT DVARMVQAPI FHVNGDDPEA CIRVASLAFE YRQAFNKDVV 
       810        820        830        840        850
IDLVCYRRRG HNEGDDPSFT QPLMYDLIEQ KRSVRKLYTE ALIGRGDITV 
       860        870        880        890        900
EEAEQAMRDF QQRLERVFTE VREAKSQPDT PAPYVTVPVY PDKPEGPDAT 
       910        920        930        940        950
ATTPEVLKKI ADAYTTLPEG FTAHPKVLPQ LQRRAAAITQ GPVDWASAEI 
       960        970        980        990       1000
TAFGSLLLAG RPVRLAGQDS RRGTFVQRFA AIIDRVNGQD HVPLQHLGED 
      1010       1020       1030       1040       1050
QANFYVYDSL LSEYAALGFE YGYSVARPDA LVLWEAQFGD FVNGAQSIID 
      1060       1070       1080       1090       1100
EYISAGEAKW GQKSGVVLLL PHGYEGQGPD HSSARIERFL TLCAENAMTV 
      1110       1120       1130       1140       1150
AQPSTPASYF HLLRRHTLQE EHNPLIVFTP KQLLRRKEAV SQPEELTSGS 
      1160       1170       1180       1190       1200
FRPVLNDSDA EQNPATVERV ILASGRISYD LLAERKKVEP DKISTAVLRV 
      1210       1220       1230       1240       1250
EQLYPLPTEQ IKAELAKYPN ATEIRWVQDE PANQGPWPFM ALNLTEHLGG 
      1260       1270       1280 
KPFYRVSRPA MSAPSVGSMG VHQAEQATLL KQAFS                 

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ