Kfla_5184

Functionⁱ

GO - Molecular functionⁱ

oxoglutarate dehydrogenase (succinyl-transferring) activity Source: InterPro
thiamine pyrophosphate binding Source: InterPro
transferase activity, transferring acyl groups Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

tricarboxylic acid cycle Source: InterPro

Complete GO annotation...

Enzyme and pathway databases

BioCycⁱ	KFLA479435:GI0F-5111-MONOMER.

BioCycⁱ

KFLA479435:GI0F-5111-MONOMER.

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: 2-oxoglutarate dehydrogenase, E1 subunitImported
Gene namesⁱ	Ordered Locus Names:Kfla_5184Imported
Organismⁱ	Kribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399)Imported
Taxonomic identifierⁱ	479435 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Actinobacteria › Actinobacteria › Propionibacteriales › Nocardioidaceae › Kribbella › Kribbella flavida
Proteomesⁱ	UP000007967 Componentⁱ: Chromosome

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	479435.Kfla_5184.

STRINGⁱ

479435.Kfla_5184.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	D2Q4U4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	943 – 1136	Transket_pyrInterPro annotationAdd BLAST		194

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	850 – 877	Sequence analysisAdd BLAST		28

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	ENOG4105C7P. Bacteria. COG0508. LUCA. COG0567. LUCA.
HOGENOMⁱ	HOG000259587.
KEGG Orthology (KO) More...KOⁱ	K00164.
OMAⁱ	IDMVCYR.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H03SK.

Family and domain databases

InterProⁱ	View protein in InterPro IPR001078. 2-oxoacid_DH_actylTfrase. IPR032106. 2-oxogl_dehyd_N. IPR011603. 2oxoglutarate_DH_E1. IPR001017. DH_E1. IPR031717. KGD_C. IPR029061. THDP-binding. IPR005475. Transketolase-like_Pyr-bd.
PANTHERⁱ	PTHR23152. PTHR23152. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00198. 2-oxoacid_dh. 1 hit. PF16078. 2-oxogl_dehyd_N. 1 hit. PF00676. E1_dh. 1 hit. PF16870. OxoGdeHyase_C. 1 hit. PF02779. Transket_pyr. 1 hit.
SMARTⁱ	View protein in SMART SM00861. Transket_pyr. 1 hit.
SUPFAMⁱ	SSF52518. SSF52518. 2 hits.
TIGRFAMsⁱ	TIGR00239. 2oxo_dh_E1. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

D2Q4U4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MATEPSDTNP LAAFGSNEWL VDEMYEKYQQ DPKSVDPAWQ TYFESDGFKG 
        60         70         80         90        100
SGPGDAKPVT TGPADAPRPD AVSDNKTPEA AVRGTTATAP AASKPAAQAA 
       110        120        130        140        150
ARTPEQAAPP TTASTAQPAQ SRPAQTQPPA SAQQTAPAAS GAPTGGTVNQ 
       160        170        180        190        200
PPSAQPKPAP ATSTDAERKV LRGAPARTAQ NMETSLQVPT ATSVRQVPVK 
       210        220        230        240        250
LLIDNRIVIN NHLKRARGGK ISFTHLIGWA LVKALKTLPE MNASYDETEG 
       260        270        280        290        300
KPTLVQPAHI NLGLAIDMAK PDGTRQLLVP SIKAAETMTF AEFWMAYEDI 
       310        320        330        340        350
VRRARDNKLA LPDFQGTTIS LTNPGTIGTQ HSVPRLMSGQ GCIIGVGAME 
       360        370        380        390        400
YPPEYQGAAE ETMAKLAVSK VMTLTSTYDH RIIQGAQSGE FLRKIHQLLL 
       410        420        430        440        450
GEEGFYDEIF QSLRIPYEPI RWAADLPHSH EEDISKQARI LELIHAYRVR 
       460        470        480        490        500
GHIMADTDPL EYKQRSHPDL DVATHGLTLW DLDREFATGS FGAATDRRFM 
       510        520        530        540        550
KLREILGILR DSYCRTTGVE YMHIQDPEQR KWLQERIERP HTKPPREEQL 
       560        570        580        590        600
RILAKLNEAE AFETFLQTKY VGQKRFSLEG GETTIPLLDE LCEEAAGAGL 
       610        620        630        640        650
DEVVIGMAHR GRLNVLANIV GKSYGQIFRE FDGNIDPRTV QGSGDVKYHL 
       660        670        680        690        700
GAEGEFVSEF GDKIKVSVAA NPSHLETVDP VLEGIVRAKQ DILDRGAAFP 
       710        720        730        740        750
VLPVLVHGDA AFAGQGVVAE TLNLSQLRGY RTGGTIHVIV NNQVGFTTSP 
       760        770        780        790        800
ASSRSSMYCT DVARMVQAPI FHVNGDDPEA CIRVASLAFE YRQAFNKDVV 
       810        820        830        840        850
IDLVCYRRRG HNEGDDPSFT QPLMYDLIEQ KRSVRKLYTE ALIGRGDITV 
       860        870        880        890        900
EEAEQAMRDF QQRLERVFTE VREAKSQPDT PAPYVTVPVY PDKPEGPDAT 
       910        920        930        940        950
ATTPEVLKKI ADAYTTLPEG FTAHPKVLPQ LQRRAAAITQ GPVDWASAEI 
       960        970        980        990       1000
TAFGSLLLAG RPVRLAGQDS RRGTFVQRFA AIIDRVNGQD HVPLQHLGED 
      1010       1020       1030       1040       1050
QANFYVYDSL LSEYAALGFE YGYSVARPDA LVLWEAQFGD FVNGAQSIID 
      1060       1070       1080       1090       1100
EYISAGEAKW GQKSGVVLLL PHGYEGQGPD HSSARIERFL TLCAENAMTV 
      1110       1120       1130       1140       1150
AQPSTPASYF HLLRRHTLQE EHNPLIVFTP KQLLRRKEAV SQPEELTSGS 
      1160       1170       1180       1190       1200
FRPVLNDSDA EQNPATVERV ILASGRISYD LLAERKKVEP DKISTAVLRV 
      1210       1220       1230       1240       1250
EQLYPLPTEQ IKAELAKYPN ATEIRWVQDE PANQGPWPFM ALNLTEHLGG 
      1260       1270       1280 
KPFYRVSRPA MSAPSVGSMG VHQAEQATLL KQAFS

Length:1,285

Mass (Da):141,182

Last modified:March 2, 2010 - v1

Checksum:ⁱ870E6A9418019FA0

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP001736 Genomic DNA. Translation: ADB34199.1.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

CP001736 Genomic DNA. Translation: ADB34199.1.

Genome annotation databases

EnsemblBacteriaⁱ	ADB34199; ADB34199; Kfla_5184.
KEGGⁱ	kfl:Kfla_5184.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP001736 Genomic DNA. Translation: ADB34199.1.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

CP001736 Genomic DNA. Translation: ADB34199.1.

3D structure databases

ProteinModelPortalⁱ	D2Q4U4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	479435.Kfla_5184.

STRINGⁱ

479435.Kfla_5184.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ADB34199; ADB34199; Kfla_5184.
KEGGⁱ	kfl:Kfla_5184.

Phylogenomic databases

eggNOGⁱ	ENOG4105C7P. Bacteria. COG0508. LUCA. COG0567. LUCA.
HOGENOMⁱ	HOG000259587.
KEGG Orthology (KO) More...KOⁱ	K00164.
OMAⁱ	IDMVCYR.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H03SK.

Enzyme and pathway databases

BioCycⁱ	KFLA479435:GI0F-5111-MONOMER.

BioCycⁱ

KFLA479435:GI0F-5111-MONOMER.

Family and domain databases

InterProⁱ	View protein in InterPro IPR001078. 2-oxoacid_DH_actylTfrase. IPR032106. 2-oxogl_dehyd_N. IPR011603. 2oxoglutarate_DH_E1. IPR001017. DH_E1. IPR031717. KGD_C. IPR029061. THDP-binding. IPR005475. Transketolase-like_Pyr-bd.
PANTHERⁱ	PTHR23152. PTHR23152. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00198. 2-oxoacid_dh. 1 hit. PF16078. 2-oxogl_dehyd_N. 1 hit. PF00676. E1_dh. 1 hit. PF16870. OxoGdeHyase_C. 1 hit. PF02779. Transket_pyr. 1 hit.
SMARTⁱ	View protein in SMART SM00861. Transket_pyr. 1 hit.
SUPFAMⁱ	SSF52518. SSF52518. 2 hits.
TIGRFAMsⁱ	TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	D2Q4U4_KRIFD
Accessionⁱ	D2Q4U4Primary (citable) accession number: D2Q4U4
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 2, 2010
	Last sequence update:	March 2, 2010
	Last modified:	July 5, 2017
	This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB - D2Q4U4 (D2Q4U4_KRIFD)

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2-oxoglutarate dehydrogenase, E1 subunit

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

Interactionⁱ

Protein-protein interaction databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Coiled coil

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - D2Q4U4 (D2Q4U4_KRIFD)

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2-oxoglutarate dehydrogenase, E1 subunit

Kfla_5184

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ