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Protein

1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase

Gene

mshB

Organism
Kribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.UniRule annotation

Catalytic activityi

1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O = 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + acetate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi15 – 151ZincUniRule annotation
Metal bindingi18 – 181ZincUniRule annotation
Metal bindingi157 – 1571ZincUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciKFLA479435:GI0F-5579-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylaseUniRule annotation (EC:3.5.1.103UniRule annotation)
Short name:
GlcNAc-Ins deacetylaseUniRule annotation
Alternative name(s):
N-acetyl-1-D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase
Gene namesi
Name:mshBUniRule annotation
Ordered Locus Names:Kfla_5531
OrganismiKribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399)
Taxonomic identifieri479435 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesNocardioidaceaeKribbella
Proteomesi
  • UP000007967 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3033031D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylasePRO_0000400191Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi479435.Kfla_5531.

Structurei

3D structure databases

ProteinModelPortaliD2PN56.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MshB deacetylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108KZ5. Bacteria.
COG2120. LUCA.
HOGENOMiHOG000241173.
KOiK15525.
OMAiAHRVATY.
OrthoDBiPOG091H08W5.

Family and domain databases

Gene3Di3.40.50.10320. 1 hit.
HAMAPiMF_01696. MshB. 1 hit.
InterProiIPR003737. GlcNAc_PI_deacetylase-related.
IPR024078. LmbE-like_dom.
IPR017810. Mycothiol_biosynthesis_MshB.
[Graphical view]
PANTHERiPTHR12993. PTHR12993. 2 hits.
PfamiPF02585. PIG-L. 1 hit.
[Graphical view]
SUPFAMiSSF102588. SSF102588. 1 hit.
TIGRFAMsiTIGR03445. mycothiol_MshB. 1 hit.

Sequencei

Sequence statusi: Complete.

D2PN56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELPDRRLL LVHAHPDDET INNGATMARY VAEGAHVTLV TCTLGEEGEV
60 70 80 90 100
LVPELAHLAA DQSDQLGRHR IGELAAAMDE LGVTDHRFLG GPGRYRDTGM
110 120 130 140 150
IYDEQGNAAV PPDTRPDSFW QADLVTAAND LVTVIREVRP QVLVTYDEFG
160 170 180 190 200
NYGHPDHVQA HRVATYAAAL AAARSYREDL GPAWDIPKIY WTAISETAMR
210 220 230 240 250
SSLRRLRESG DHTTFEGMDP DGPLGPMITP DRFIDCVIPA DGYLDRKMNA
260 270 280 290 300
MKAHATQITV DGPFFALSNN DGNEIFGDEF YRLVKGTAAP GSDGLEHDLF

AGL
Length:303
Mass (Da):33,186
Last modified:March 2, 2010 - v1
Checksum:iF9B904980C25C372
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001736 Genomic DNA. Translation: ADB34540.1.
RefSeqiWP_012923094.1. NC_013729.1.

Genome annotation databases

EnsemblBacteriaiADB34540; ADB34540; Kfla_5531.
KEGGikfl:Kfla_5531.
PATRICi32241566. VBIKriFla67707_5534.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001736 Genomic DNA. Translation: ADB34540.1.
RefSeqiWP_012923094.1. NC_013729.1.

3D structure databases

ProteinModelPortaliD2PN56.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi479435.Kfla_5531.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADB34540; ADB34540; Kfla_5531.
KEGGikfl:Kfla_5531.
PATRICi32241566. VBIKriFla67707_5534.

Phylogenomic databases

eggNOGiENOG4108KZ5. Bacteria.
COG2120. LUCA.
HOGENOMiHOG000241173.
KOiK15525.
OMAiAHRVATY.
OrthoDBiPOG091H08W5.

Enzyme and pathway databases

BioCyciKFLA479435:GI0F-5579-MONOMER.

Family and domain databases

Gene3Di3.40.50.10320. 1 hit.
HAMAPiMF_01696. MshB. 1 hit.
InterProiIPR003737. GlcNAc_PI_deacetylase-related.
IPR024078. LmbE-like_dom.
IPR017810. Mycothiol_biosynthesis_MshB.
[Graphical view]
PANTHERiPTHR12993. PTHR12993. 2 hits.
PfamiPF02585. PIG-L. 1 hit.
[Graphical view]
SUPFAMiSSF102588. SSF102588. 1 hit.
TIGRFAMsiTIGR03445. mycothiol_MshB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMSHB_KRIFD
AccessioniPrimary (citable) accession number: D2PN56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: March 2, 2010
Last modified: September 7, 2016
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.