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D2PN22

- D2PN22_KRIFD

UniProt

D2PN22 - D2PN22_KRIFD

Protein

Kynureninase

Gene

kynU

Organism
Kribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (02 Mar 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

    Catalytic activityi

    L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
    L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei111 – 1111Pyridoxal phosphate; via amide nitrogenUniRule annotation
    Binding sitei112 – 1121Pyridoxal phosphateUniRule annotation
    Binding sitei221 – 2211Pyridoxal phosphateUniRule annotation
    Binding sitei224 – 2241Pyridoxal phosphateUniRule annotation
    Binding sitei246 – 2461Pyridoxal phosphateUniRule annotation
    Binding sitei280 – 2801Pyridoxal phosphateUniRule annotation
    Binding sitei308 – 3081Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. kynureninase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
    4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    5. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    HydrolaseUniRule annotation

    Keywords - Biological processi

    Pyridine nucleotide biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciKFLA479435:GI0F-5543-MONOMER.
    UniPathwayiUPA00253; UER00329.
    UPA00334; UER00455.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
    Alternative name(s):
    L-kynurenine hydrolaseUniRule annotation
    Gene namesi
    Name:kynUUniRule annotation
    Ordered Locus Names:Kfla_5495Imported
    OrganismiKribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399)Imported
    Taxonomic identifieri479435 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaeNocardioidaceaeKribbella
    ProteomesiUP000007967: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei247 – 2471N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni139 – 1424Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the kynureninase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000242438.
    KOiK01556.
    OMAiGLMNDIV.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01970. Kynureninase.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR14084. PTHR14084. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038800. KYNU. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01814. kynureninase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D2PN22-1 [UniParc]FASTAAdd to Basket

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    MTEPGRPISE GEREAFALDA ADPGHRELFD VPPWPDGYYP DVAYFAGNSL    50
    GLRPKATRSE LLADLDAWAE LGVEGHLEAG RPWLPYHELL TGPAARLVGA 100
    LPTETVVMNS LTVDLHLLMV SFYRPAPDRY RILIEDSAFP SDSYAVRSQA 150
    AWHGFDPDDA IVRVRPRDGE DCLRTEDVIA RIGPDVALVL LGGVNYLTGE 200
    LLDIPAITAA GHAAGAVVGW DLAHAAGNVP LRLHAWDVDF AAWCSYKYLN 250
    AGPGALAGVF VHERHHPADD RAGRPRFEGW WSTEQATRFA MAPLSRPPRS 300
    AEAWQVSNPP IFAMSPVRTS LELFDRIGMD VLRERSLRLT AYLERLLAGI 350
    TPSRPLRVIT PADPARRGAQ LSVRIGGGLR AGELTKRLRF EFGVIADARE 400
    PDVVRLAPVP LYSLYHDCRR AVEALAEAVP ETA 433
    Length:433
    Mass (Da):47,502
    Last modified:March 2, 2010 - v1
    Checksum:i1D9007C435DD782C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001736 Genomic DNA. Translation: ADB34506.1.
    RefSeqiWP_012923060.1. NC_013729.1.
    YP_003383305.1. NC_013729.1.

    Genome annotation databases

    EnsemblBacteriaiADB34506; ADB34506; Kfla_5495.
    GeneIDi8722120.
    KEGGikfl:Kfla_5495.
    PATRICi32241490. VBIKriFla67707_5496.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001736 Genomic DNA. Translation: ADB34506.1 .
    RefSeqi WP_012923060.1. NC_013729.1.
    YP_003383305.1. NC_013729.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADB34506 ; ADB34506 ; Kfla_5495 .
    GeneIDi 8722120.
    KEGGi kfl:Kfla_5495.
    PATRICi 32241490. VBIKriFla67707_5496.

    Phylogenomic databases

    HOGENOMi HOG000242438.
    KOi K01556.
    OMAi GLMNDIV.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00329 .
    UPA00334 ; UER00455 .
    BioCyci KFLA479435:GI0F-5543-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01970. Kynureninase.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR14084. PTHR14084. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038800. KYNU. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01814. kynureninase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 17836 / JCM 10339 / NBRC 14399Imported.

    Entry informationi

    Entry nameiD2PN22_KRIFD
    AccessioniPrimary (citable) accession number: D2PN22
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 2, 2010
    Last sequence update: March 2, 2010
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3