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D2PN22 (D2PN22_KRIFD) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Kynureninase PIRNR PIRNR038800
EC=3.7.1.3 PIRNR PIRNR038800
Gene names
Ordered Locus Names:Kfla_5495
OrganismKribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399) [Complete proteome] [HAMAP]
Taxonomic identifier479435 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Nocardioidaceae › Kribbella ›

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity. PIRNR PIRNR038800

Catalytic activity

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. PIRNR PIRNR038800

L-kynurenine + H2O = anthranilate + L-alanine. PIRNR PIRNR038800

Cofactor

Pyridoxal phosphate By similarity. PIRNR PIRNR038800

Pathway

Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. PIRNR PIRNR038800

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. PIRNR PIRNR038800

Subunit structure

Homodimer By similarity. PIRNR PIRNR038800

Sequence similarities

Belongs to the kynureninase family. PIRNR PIRNR038800

Sequences

Sequence LengthMass (Da)Tools
D2PN22 [UniParc].

Last modified March 2, 2010. Version 1.
Checksum: 1D9007C435DD782C

FASTA43347,502
        10         20         30         40         50         60 
MTEPGRPISE GEREAFALDA ADPGHRELFD VPPWPDGYYP DVAYFAGNSL GLRPKATRSE 

        70         80         90        100        110        120 
LLADLDAWAE LGVEGHLEAG RPWLPYHELL TGPAARLVGA LPTETVVMNS LTVDLHLLMV 

       130        140        150        160        170        180 
SFYRPAPDRY RILIEDSAFP SDSYAVRSQA AWHGFDPDDA IVRVRPRDGE DCLRTEDVIA 

       190        200        210        220        230        240 
RIGPDVALVL LGGVNYLTGE LLDIPAITAA GHAAGAVVGW DLAHAAGNVP LRLHAWDVDF 

       250        260        270        280        290        300 
AAWCSYKYLN AGPGALAGVF VHERHHPADD RAGRPRFEGW WSTEQATRFA MAPLSRPPRS 

       310        320        330        340        350        360 
AEAWQVSNPP IFAMSPVRTS LELFDRIGMD VLRERSLRLT AYLERLLAGI TPSRPLRVIT 

       370        380        390        400        410        420 
PADPARRGAQ LSVRIGGGLR AGELTKRLRF EFGVIADARE PDVVRLAPVP LYSLYHDCRR 

       430 
AVEALAEAVP ETA

« Hide

References

[1]"The complete genome of Kribbella flavida DSM 17836."
US DOE Joint Genome Institute (JGI-PGF)
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M. expand/collapse author list , Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Pukall R., Klenk H.-P., Eisen J.A.
Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 17836 / JCM 10339 / NBRC 14399.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001736 Genomic DNA. Translation: ADB34506.1.
RefSeqYP_003383305.1. NC_013729.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADB34506; ADB34506; Kfla_5495.
GeneID8722120.
KEGGkfl:Kfla_5495.
PATRIC32241490. VBIKriFla67707_5496.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000242438.
KOK01556.
OMAMVSFYRP.

Enzyme and pathway databases

BioCycKFLA479435:GI0F-5542-MONOMER.
UniPathwayUPA00253; UER00329.
UPA00334; UER00455.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR14084. PTHR14084. 1 hit.
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFPIRSF038800. KYNU. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMsTIGR01814. kynureninase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameD2PN22_KRIFD
AccessionPrimary (citable) accession number: D2PN22
Entry history
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: May 1, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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