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D2PN22

- D2PN22_KRIFD

UniProt

D2PN22 - D2PN22_KRIFD

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Protein

Kynureninase

Gene
kynU, Kfla_5495
Organism
Kribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei111 – 1111Pyridoxal phosphate; via amide nitrogen By similarityUniRule annotation
Binding sitei112 – 1121Pyridoxal phosphate By similarityUniRule annotation
Binding sitei221 – 2211Pyridoxal phosphate By similarityUniRule annotation
Binding sitei224 – 2241Pyridoxal phosphate By similarityUniRule annotation
Binding sitei246 – 2461Pyridoxal phosphate By similarityUniRule annotation
Binding sitei280 – 2801Pyridoxal phosphate By similarityUniRule annotation
Binding sitei308 – 3081Pyridoxal phosphate By similarityUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciKFLA479435:GI0F-5543-MONOMER.
UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolase
Gene namesi
Name:kynUUniRule annotation
Ordered Locus Names:Kfla_5495Imported
OrganismiKribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399)Imported
Taxonomic identifieri479435 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaeNocardioidaceaeKribbella
ProteomesiUP000007967: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei247 – 2471N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni139 – 1424Pyridoxal phosphate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000242438.
KOiK01556.
OMAiGLMNDIV.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

D2PN22-1 [UniParc]FASTAAdd to Basket

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MTEPGRPISE GEREAFALDA ADPGHRELFD VPPWPDGYYP DVAYFAGNSL    50
GLRPKATRSE LLADLDAWAE LGVEGHLEAG RPWLPYHELL TGPAARLVGA 100
LPTETVVMNS LTVDLHLLMV SFYRPAPDRY RILIEDSAFP SDSYAVRSQA 150
AWHGFDPDDA IVRVRPRDGE DCLRTEDVIA RIGPDVALVL LGGVNYLTGE 200
LLDIPAITAA GHAAGAVVGW DLAHAAGNVP LRLHAWDVDF AAWCSYKYLN 250
AGPGALAGVF VHERHHPADD RAGRPRFEGW WSTEQATRFA MAPLSRPPRS 300
AEAWQVSNPP IFAMSPVRTS LELFDRIGMD VLRERSLRLT AYLERLLAGI 350
TPSRPLRVIT PADPARRGAQ LSVRIGGGLR AGELTKRLRF EFGVIADARE 400
PDVVRLAPVP LYSLYHDCRR AVEALAEAVP ETA 433
Length:433
Mass (Da):47,502
Last modified:March 2, 2010 - v1
Checksum:i1D9007C435DD782C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001736 Genomic DNA. Translation: ADB34506.1.
RefSeqiWP_012923060.1. NC_013729.1.
YP_003383305.1. NC_013729.1.

Genome annotation databases

EnsemblBacteriaiADB34506; ADB34506; Kfla_5495.
GeneIDi8722120.
KEGGikfl:Kfla_5495.
PATRICi32241490. VBIKriFla67707_5496.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001736 Genomic DNA. Translation: ADB34506.1 .
RefSeqi WP_012923060.1. NC_013729.1.
YP_003383305.1. NC_013729.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADB34506 ; ADB34506 ; Kfla_5495 .
GeneIDi 8722120.
KEGGi kfl:Kfla_5495.
PATRICi 32241490. VBIKriFla67707_5496.

Phylogenomic databases

HOGENOMi HOG000242438.
KOi K01556.
OMAi GLMNDIV.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .
BioCyci KFLA479435:GI0F-5543-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17836 / JCM 10339 / NBRC 14399.

Entry informationi

Entry nameiD2PN22_KRIFD
AccessioniPrimary (citable) accession number: D2PN22
Entry historyi
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: September 3, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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