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D2PMB8 (D2PMB8_KRIFD) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ATP phosphoribosyltransferase HAMAP-Rule MF_00079
Short name=ATP-PRT HAMAP-Rule MF_00079
Short name=ATP-PRTase HAMAP-Rule MF_00079
EC=2.4.2.17 HAMAP-Rule MF_00079
Gene names
Name:hisG HAMAP-Rule MF_00079
Ordered Locus Names:Kfla_5475
OrganismKribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399) [Complete proteome] [HAMAP]
Taxonomic identifier479435 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Nocardioidaceae › Kribbella ›

Protein attributes

Sequence length281 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity By similarity. HAMAP-Rule MF_00079

Catalytic activity

1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00079 SAAS SAAS018198

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00079

Enzyme regulation

Feedback inhibited by histidine By similarity. HAMAP-Rule MF_00079

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. HAMAP-Rule MF_00079 SAAS SAAS018198

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00079.

Sequence similarities

Belongs to the ATP phosphoribosyltransferase family. Long subfamily. HAMAP-Rule MF_00079

Sequences

Sequence LengthMass (Da)Tools
D2PMB8 [UniParc].

Last modified March 2, 2010. Version 1.
Checksum: B2E5A49BD2D3EE68

FASTA28130,053
        10         20         30         40         50         60 
MLRVAVPNKG SLSEAATAIL IEAGYKQRRT TKDLSLTDPD NGVEFYYLRP RDIAVYVGEG 

        70         80         90        100        110        120 
TLDVGISGRD LVLDSHADAD TIIELGFGGS TFRFAGRPGV ADSVKDLAGK RIATSFAGIL 

       130        140        150        160        170        180 
SDHLAEHGVE ASVVKLDGAV ESAVQLGVAD VIADVVETGT TLRQAGLEVF GEPILTSEAV 

       190        200        210        220        230        240 
LIKRHGVEQP AGLEQLVRRL QGVLVARNYV MMDYDIRAEA VEAANAVAPG LESPTVSPLH 

       250        260        270        280 
REGWVAVRVM VLRSEAQNIM DQLWDVGARA ILTTDIHACR I

« Hide

References

[1]"The complete genome of Kribbella flavida DSM 17836."
US DOE Joint Genome Institute (JGI-PGF)
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M. expand/collapse author list , Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Pukall R., Klenk H.-P., Eisen J.A.
Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 17836 / JCM 10339 / NBRC 14399.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001736 Genomic DNA. Translation: ADB34486.1.
RefSeqYP_003383285.1. NC_013729.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADB34486; ADB34486; Kfla_5475.
GeneID8722100.
KEGGkfl:Kfla_5475.
PATRIC32241450. VBIKriFla67707_5476.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000223250.
KOK00765.
OMAEGKHIAT.

Enzyme and pathway databases

BioCycKFLA479435:GI0F-5522-MONOMER.
UniPathwayUPA00031; UER00006.

Family and domain databases

Gene3D3.30.70.120. 1 hit.
HAMAPMF_00079. HisG_Long.
InterProIPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR020621. ATP_PRibTrfase_HisG_long.
IPR013115. HisG_C.
IPR011322. N-reg_PII-like_a/b.
IPR015867. N-reg_PII/ATP_PRibTrfase_C.
[Graphical view]
PANTHERPTHR21403. PTHR21403. 1 hit.
PfamPF01634. HisG. 1 hit.
PF08029. HisG_C. 1 hit.
[Graphical view]
SUPFAMSSF54913. N-reg_PII-like_a/b. 1 hit.
TIGRFAMsTIGR00070. hisG. 1 hit.
TIGR03455. HisG_C-term. 1 hit.
PROSITEPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD2PMB8_KRIFD
AccessionPrimary (citable) accession number: D2PMB8
Entry history
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: May 1, 2013
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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