ID   D2PLU1_KRIFD            Unreviewed;       569 AA.
AC   D2PLU1;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 61.
DE   SubName: Full=AMP-dependent synthetase and ligase {ECO:0000313|EMBL:ADB32521.1};
GN   OrderedLocusNames=Kfla_3463 {ECO:0000313|EMBL:ADB32521.1};
OS   Kribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399).
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Kribbellaceae; Kribbella.
OX   NCBI_TaxID=479435 {ECO:0000313|EMBL:ADB32521.1, ECO:0000313|Proteomes:UP000007967};
RN   [1] {ECO:0000313|Proteomes:UP000007967}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17836 / JCM 10339 / NBRC 14399
RC   {ECO:0000313|Proteomes:UP000007967};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA   Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M.,
RA   Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D.,
RA   Pukall R., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of Kribbella flavida DSM 17836.";
RL   Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADB32521.1, ECO:0000313|Proteomes:UP000007967}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17836 / JCM 10339 / NBRC 14399
RC   {ECO:0000313|Proteomes:UP000007967};
RX   PubMed=21304701;
RA   Pukall R., Lapidus A., Glavina Del Rio T., Copeland A., Tice H.,
RA   Cheng J.-F., Lucas S., Chen F., Nolan M., LaButti K., Pati A., Ivanova N.,
RA   Mavrommatis K., Mikhailova N., Pitluck S., Bruce D., Goodwin L., Land M.,
RA   Hauser L., Chang Y.-J., Jeffries C.D., Chen A., Palaniappan K., Chain P.,
RA   Rohde M., Goeker M., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.-P., Brettin T.;
RT   "Complete genome sequence of Kribbella flavida type strain (IFO 14399).";
RL   Stand. Genomic Sci. 2:186-193(2010).
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000256|ARBA:ARBA00006432}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001736; ADB32521.1; -; Genomic_DNA.
DR   RefSeq; WP_012921077.1; NC_013729.1.
DR   AlphaFoldDB; D2PLU1; -.
DR   STRING; 479435.Kfla_3463; -.
DR   KEGG; kfl:Kfla_3463; -.
DR   eggNOG; COG0365; Bacteria.
DR   HOGENOM; CLU_000022_59_10_11; -.
DR   OrthoDB; 9803968at2; -.
DR   Proteomes; UP000007967; Chromosome.
DR   GO; GO:0016878; F:acid-thiol ligase activity; IEA:UniProt.
DR   GO; GO:0016405; F:CoA-ligase activity; IEA:UniProt.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR43605:SF10; ACYL-COA SYNTHETASE MEDIUM CHAIN FAMILY MEMBER 3; 1.
DR   PANTHER; PTHR43605; ACYL-COENZYME A SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   3: Inferred from homology;
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ADB32521.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007967}.
FT   DOMAIN          54..409
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          460..537
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
FT   REGION          548..569
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   569 AA;  62917 MW;  2E4DA78CB58B8A9A CRC64;
     MSEEQSTSET TRAFREARDF LIAHREDYDT AYRDFSWPAF DRFNWARDWF DALAVEQPEV
     AALTIVEEDG EVNSLTYGEM AERSRQVAGW LTEQGLQPGD RVLIVLGNTV PLWEVMLACI
     RAGAVMIPAT TLLTDADLAD RITRGGVRAV VTSTADAARY EGIADHCLRI GIGEPVEGWL
     DYEQTREYDG PVPEVDTSAD DSLLLYFTSG TTSEPKLVEH TQVSYPVGHL STMYWVGLQP
     GDVHLNVSSP GWAKHSWSNV FAPWNAGATV FLYNYTRFDA EKMLQVLATY GVTTFCAPPT
     VWRMLIQADL SVVEVRVREC ISAGEPLNPE VIEQVRNAWG ITIRDGYGQT ETTAQIGNPP
     GQPVKPGSMG RPLPGYSIAL VDPATDAVGD DGEICIELAP PPVPLMRGYR DAKALTDEVM
     RGGFYHTGDV AHRDEDGYIT YVGRSDDVFK ASDYRISPFE LESVLIEHPA VAEAAVVPSP
     DPVRLAVPKA YVVLAAGYEP SRELAGQILA YCRDHLAAYQ RIRRIEFAEL PKTISGKIRR
     VELRAEEAGK VESGERTGHA YDETDFRDS
//