ID   D2PL39_KRIFD            Unreviewed;       604 AA.
AC   D2PL39;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 71.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   OrderedLocusNames=Kfla_5280 {ECO:0000313|EMBL:ADB34294.1};
OS   Kribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399).
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Kribbellaceae; Kribbella.
OX   NCBI_TaxID=479435 {ECO:0000313|EMBL:ADB34294.1, ECO:0000313|Proteomes:UP000007967};
RN   [1] {ECO:0000313|Proteomes:UP000007967}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17836 / JCM 10339 / NBRC 14399
RC   {ECO:0000313|Proteomes:UP000007967};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA   Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M.,
RA   Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D.,
RA   Pukall R., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of Kribbella flavida DSM 17836.";
RL   Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADB34294.1, ECO:0000313|Proteomes:UP000007967}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17836 / JCM 10339 / NBRC 14399
RC   {ECO:0000313|Proteomes:UP000007967};
RX   PubMed=21304701;
RA   Pukall R., Lapidus A., Glavina Del Rio T., Copeland A., Tice H.,
RA   Cheng J.-F., Lucas S., Chen F., Nolan M., LaButti K., Pati A., Ivanova N.,
RA   Mavrommatis K., Mikhailova N., Pitluck S., Bruce D., Goodwin L., Land M.,
RA   Hauser L., Chang Y.-J., Jeffries C.D., Chen A., Palaniappan K., Chain P.,
RA   Rohde M., Goeker M., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.-P., Brettin T.;
RT   "Complete genome sequence of Kribbella flavida type strain (IFO 14399).";
RL   Stand. Genomic Sci. 2:186-193(2010).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family.
CC       {ECO:0000256|ARBA:ARBA00009348}.
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DR   EMBL; CP001736; ADB34294.1; -; Genomic_DNA.
DR   RefSeq; WP_012922848.1; NC_013729.1.
DR   AlphaFoldDB; D2PL39; -.
DR   STRING; 479435.Kfla_5280; -.
DR   CAZy; GH33; Glycoside Hydrolase Family 33.
DR   KEGG; kfl:Kfla_5280; -.
DR   eggNOG; COG4409; Bacteria.
DR   HOGENOM; CLU_430157_0_0_11; -.
DR   OrthoDB; 7294637at2; -.
DR   Proteomes; UP000007967; Chromosome.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   CDD; cd00110; LamG; 1.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR006558; LamG-like.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   Pfam; PF13385; Laminin_G_3; 1.
DR   SMART; SM00560; LamGL; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007967};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..604
FT                   /note="exo-alpha-sialidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003034441"
FT   DOMAIN          447..581
FT                   /note="LamG-like jellyroll fold"
FT                   /evidence="ECO:0000259|SMART:SM00560"
SQ   SEQUENCE   604 AA;  64402 MW;  57A23D427F69B459 CRC64;
     MPTPLRLMLA LVLVLPALTA TTAGARPMAE PAAVVQTVLF DKGGAGYGCY RIPAIVRTKA
     GTLLAFAEAR RTWCGDSQEI DLVMRRSTDN GRTWSAQKVV LSGTDTDPNA VATRGNPTPI
     VDYQTGRIVL LTTMDPGNGT DRPRTPYVQF SEDDGLTFSK ARSIGGQIDD PAWGWYATGP
     VHGIQLTRGA HQGRLVAGTN YDVSGKHAGQ LVYSDDSGET WHKGATDLRS DGLVPQEISV
     VEKVDGGIYA GARNNGGSAG NSRAFAVSND GGESYVAPYA PVVGLTTPTV QGSLVRLRAT
     DQGAKYNRIL FASPADPERR RYLTIRSSFD EGRTWQTVEQ GTRITSDWSG YSDMAVLGTG
     EIGLLYEGGT VDARDQIRFA RFTETDIGHP DGASGPTTPD VSGLGNHSYL RGGTTAVAGR
     FGQARDLDGT DDAIQLPYAE SLALGSGDFT AMAWIRYGAS TASQAIFWGY GINEFSQFWL
     RAEPASSRIR GLITVNGSTA AVASTRAYND NAWHHVALQR KAGTLSLWVD GAQVGSVAAP
     SGSISPGRPF RMYVGQRLDG LHRFDGSLDE VRIYKRALTA AEIASIRTSN VTTVPNVVLD
     LPLG
//