Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

D2PCI8 (D2PCI8_SULID) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
ATP phosphoribosyltransferase HAMAP-Rule MF_00079

Short name=ATP-PRT HAMAP-Rule MF_00079
Short name=ATP-PRTase HAMAP-Rule MF_00079
EC=2.4.2.17 HAMAP-Rule MF_00079
Gene names
Name:hisG HAMAP-Rule MF_00079
Ordered Locus Names:LD85_1746 EMBL ADB87408.1
OrganismSulfolobus islandicus (strain L.D.8.5 / Lassen #2) [Complete proteome] [HAMAP] EMBL ADB87408.1
Taxonomic identifier425944 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

Protein attributes

Sequence length286 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity By similarity. HAMAP-Rule MF_00079

Catalytic activity

1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00079

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00079

Enzyme regulation

Feedback inhibited by histidine By similarity. HAMAP-Rule MF_00079

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. HAMAP-Rule MF_00079

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00079.

Sequence similarities

Belongs to the ATP phosphoribosyltransferase family. Long subfamily. HAMAP-Rule MF_00079

Sequences

Sequence LengthMass (Da)Tools
D2PCI8 [UniParc].

Last modified March 2, 2010. Version 1.
Checksum: 99E6CAFB48F85AF2

FASTA28631,415
        10         20         30         40         50         60 
MKIAIPNKGR LQQPTLQFLQ SVGIKPLASD DRALIVPTSW EGVQLVMIRT EDIPNIVETG 

        70         80         90        100        110        120 
ATELGITGHD YVIESSADVE ELIKLDFGRS KIVLAVPQTW SENSVEELKV REFRVATKYY 

       130        140        150        160        170        180 
NIAKEYVRKK ELNAKVVKIS GAAEVMPSLG AADAIIDVMS TGTTLKLHGL KAIDIIMDSY 

       190        200        210        220        230        240 
AVVIGNRNWI KNDEADRINL LLTMMKGAIA AKGKKMIFMN VPDNRLDGVI NSLPAMLAPA 

       250        260        270        280 
ITRLSRSDIW EVITVADEDI LPEVIAKVKA AGARDIVVID IEKVVK 

« Hide

References

[1]"Biogeography of the Sulfolobus islandicus pan-genome."
Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J.
Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: L.D.8.5 / Lassen #2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001731 Genomic DNA. Translation: ADB87408.1.
RefSeqYP_003419778.1. NC_013769.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADB87408; ADB87408; LD85_1746.
GeneID8761575.
KEGGsii:LD85_1746.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000223247.
KOK00765.
OMAYVMLDYD.

Enzyme and pathway databases

BioCycSISL425944:GHS5-1736-MONOMER.
UniPathwayUPA00031; UER00006.

Family and domain databases

Gene3D3.30.70.120. 1 hit.
HAMAPMF_00079. HisG_Long.
InterProIPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR020621. ATP_PRibTrfase_HisG_long.
IPR013115. HisG_C.
IPR011322. N-reg_PII-like_a/b.
IPR015867. N-reg_PII/ATP_PRibTrfase_C.
[Graphical view]
PANTHERPTHR21403. PTHR21403. 1 hit.
PfamPF01634. HisG. 1 hit.
PF08029. HisG_C. 1 hit.
[Graphical view]
SUPFAMSSF54913. SSF54913. 1 hit.
TIGRFAMsTIGR00070. hisG. 1 hit.
TIGR03455. HisG_C-term. 1 hit.
PROSITEPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD2PCI8_SULID
AccessionPrimary (citable) accession number: D2PCI8
Entry history
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: June 11, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)