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D2PCI8

- D2PCI8_SULID

UniProt

D2PCI8 - D2PCI8_SULID

Protein

ATP phosphoribosyltransferase

Gene

hisG

Organism
Sulfolobus islandicus (strain L.D.8.5 / Lassen #2)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (02 Mar 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.UniRule annotation

    Catalytic activityi

    1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Enzyme regulationi

    Feedback inhibited by histidine.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ATP phosphoribosyltransferase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    GlycosyltransferaseUniRule annotationImported, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesisUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSISL425944:GHS5-1736-MONOMER.
    UniPathwayiUPA00031; UER00006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP phosphoribosyltransferaseUniRule annotation (EC:2.4.2.17UniRule annotation)
    Short name:
    ATP-PRTUniRule annotation
    Short name:
    ATP-PRTaseUniRule annotation
    Gene namesi
    Name:hisGUniRule annotation
    Ordered Locus Names:LD85_1746Imported
    OrganismiSulfolobus islandicus (strain L.D.8.5 / Lassen #2)Imported
    Taxonomic identifieri425944 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001404: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP phosphoribosyltransferase family. Long subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000223247.
    KOiK00765.
    OMAiYVMLDYD.

    Family and domain databases

    Gene3Di3.30.70.120. 1 hit.
    HAMAPiMF_00079. HisG_Long.
    InterProiIPR013820. ATP_PRibTrfase_cat.
    IPR018198. ATP_PRibTrfase_CS.
    IPR001348. ATP_PRibTrfase_HisG.
    IPR020621. ATP_PRibTrfase_HisG_long.
    IPR013115. HisG_C.
    IPR011322. N-reg_PII-like_a/b.
    IPR015867. N-reg_PII/ATP_PRibTrfase_C.
    [Graphical view]
    PANTHERiPTHR21403. PTHR21403. 1 hit.
    PfamiPF01634. HisG. 1 hit.
    PF08029. HisG_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF54913. SSF54913. 1 hit.
    TIGRFAMsiTIGR00070. hisG. 1 hit.
    TIGR03455. HisG_C-term. 1 hit.
    PROSITEiPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D2PCI8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIAIPNKGR LQQPTLQFLQ SVGIKPLASD DRALIVPTSW EGVQLVMIRT    50
    EDIPNIVETG ATELGITGHD YVIESSADVE ELIKLDFGRS KIVLAVPQTW 100
    SENSVEELKV REFRVATKYY NIAKEYVRKK ELNAKVVKIS GAAEVMPSLG 150
    AADAIIDVMS TGTTLKLHGL KAIDIIMDSY AVVIGNRNWI KNDEADRINL 200
    LLTMMKGAIA AKGKKMIFMN VPDNRLDGVI NSLPAMLAPA ITRLSRSDIW 250
    EVITVADEDI LPEVIAKVKA AGARDIVVID IEKVVK 286
    Length:286
    Mass (Da):31,415
    Last modified:March 2, 2010 - v1
    Checksum:i99E6CAFB48F85AF2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001731 Genomic DNA. Translation: ADB87408.1.
    RefSeqiYP_003419778.1. NC_013769.1.

    Genome annotation databases

    EnsemblBacteriaiADB87408; ADB87408; LD85_1746.
    GeneIDi8761575.
    KEGGisii:LD85_1746.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001731 Genomic DNA. Translation: ADB87408.1 .
    RefSeqi YP_003419778.1. NC_013769.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADB87408 ; ADB87408 ; LD85_1746 .
    GeneIDi 8761575.
    KEGGi sii:LD85_1746.

    Phylogenomic databases

    HOGENOMi HOG000223247.
    KOi K00765.
    OMAi YVMLDYD.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00006 .
    BioCyci SISL425944:GHS5-1736-MONOMER.

    Family and domain databases

    Gene3Di 3.30.70.120. 1 hit.
    HAMAPi MF_00079. HisG_Long.
    InterProi IPR013820. ATP_PRibTrfase_cat.
    IPR018198. ATP_PRibTrfase_CS.
    IPR001348. ATP_PRibTrfase_HisG.
    IPR020621. ATP_PRibTrfase_HisG_long.
    IPR013115. HisG_C.
    IPR011322. N-reg_PII-like_a/b.
    IPR015867. N-reg_PII/ATP_PRibTrfase_C.
    [Graphical view ]
    PANTHERi PTHR21403. PTHR21403. 1 hit.
    Pfami PF01634. HisG. 1 hit.
    PF08029. HisG_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54913. SSF54913. 1 hit.
    TIGRFAMsi TIGR00070. hisG. 1 hit.
    TIGR03455. HisG_C-term. 1 hit.
    PROSITEi PS01316. ATP_P_PHORIBOSYLTR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: L.D.8.5 / Lassen #2Imported.

    Entry informationi

    Entry nameiD2PCI8_SULID
    AccessioniPrimary (citable) accession number: D2PCI8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 2, 2010
    Last sequence update: March 2, 2010
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3