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Protein

Imidazoleglycerol-phosphate dehydratase

Gene

hisB

Organism
Sulfolobus islandicus (strain L.D.8.5 / Lassen #2)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. imidazoleglycerol-phosphate dehydratase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciSISL425944:GHS5-1734-MONOMER.
UniPathwayiUPA00031; UER00011.

Names & Taxonomyi

Protein namesi
Recommended name:
Imidazoleglycerol-phosphate dehydrataseUniRule annotation (EC:4.2.1.19UniRule annotation)
Short name:
IGPDUniRule annotation
Gene namesi
Name:hisBUniRule annotation
Ordered Locus Names:LD85_1744Imported
OrganismiSulfolobus islandicus (strain L.D.8.5 / Lassen #2)Imported
Taxonomic identifieri425944 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001404 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the imidazoleglycerol-phosphate dehydratase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000228064.
KOiK01693.
OMAiIPMDEAK.

Family and domain databases

HAMAPiMF_00076. HisB.
InterProiIPR000807. ImidazoleglycerolP_deHydtase.
IPR020565. ImidazoleglycerP_deHydtase_CS.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR23133:SF2. PTHR23133:SF2. 1 hit.
PfamiPF00475. IGPD. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 2 hits.
PROSITEiPS00954. IGP_DEHYDRATASE_1. 1 hit.
PS00955. IGP_DEHYDRATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D2PCI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARNANITRE TKETKIEVFL DIDRKGEIKV STPVPFFNHM LITLLTYMNS
60 70 80 90 100
TATVSATDKL PYDDHHIIED VAITLGLAIK EALGDKRGIK RFSHQIIPMD
110 120 130 140 150
EALVLVSLDI SNRGMAFVSL NLRRSEIGGL ATENIPHFFQ SFAYNSGVTL
160 170 180 190
HISQLSGYNT HHIIEASFKA LGLALYEATR IVDNEIRSTK GVI
Length:193
Mass (Da):21,513
Last modified:March 2, 2010 - v1
Checksum:i0368FB1F03D1FE58
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001731 Genomic DNA. Translation: ADB87406.1.
RefSeqiWP_012952941.1. NC_013769.1.
YP_003419776.1. NC_013769.1.

Genome annotation databases

EnsemblBacteriaiADB87406; ADB87406; LD85_1744.
GeneIDi8761573.
KEGGisii:LD85_1744.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001731 Genomic DNA. Translation: ADB87406.1.
RefSeqiWP_012952941.1. NC_013769.1.
YP_003419776.1. NC_013769.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADB87406; ADB87406; LD85_1744.
GeneIDi8761573.
KEGGisii:LD85_1744.

Phylogenomic databases

HOGENOMiHOG000228064.
KOiK01693.
OMAiIPMDEAK.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00011.
BioCyciSISL425944:GHS5-1734-MONOMER.

Family and domain databases

HAMAPiMF_00076. HisB.
InterProiIPR000807. ImidazoleglycerolP_deHydtase.
IPR020565. ImidazoleglycerP_deHydtase_CS.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR23133:SF2. PTHR23133:SF2. 1 hit.
PfamiPF00475. IGPD. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 2 hits.
PROSITEiPS00954. IGP_DEHYDRATASE_1. 1 hit.
PS00955. IGP_DEHYDRATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: L.D.8.5 / Lassen #2Imported.

Entry informationi

Entry nameiD2PCI6_SULID
AccessioniPrimary (citable) accession number: D2PCI6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: April 29, 2015
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.